Localization of cells preferentially expressing GAD67 with negligible GAD65 transcripts in the rat hippocampus. A double in situ hybridization study

The rat nervous system

1985 • 3,774 citations

Handbook of Neurochemistry

1972 • 1,374 citations

Two genes encode distinct glutamate decarboxylases

1991 • 1,195 citations

Gene Expression for Glutamic Acid Decarboxylase Is Reduced Without Loss of Neurons in Prefrontal Cortex of Schizophrenics

1995 • 1,007 citations

Two Forms of the γ‐Aminobutyric Acid Synthetic Enzyme Glutamate Decarboxylase Have Distinct Intraneuronal Distributions and Cofactor Interactions

1991 • 781 citations

Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms

1994 • 610 citations

Regulation of γ‐Aminobutyric Acid Synthesis in the Brain

1993 • 596 citations

Cleft palate and decreased brain γ-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

1997 • 549 citations

GABA in nervous system function

1976 • 529 citations

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.

1992 • 487 citations

Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics

1992 • 371 citations

Mice Lacking the 65 kDa Isoform of Glutamic Acid Decarboxylase (GAD65) Maintain Normal Levels of GAD67 and GABA in Their Brains but Are Susceptible to Seizures

1996 • 322 citations

Reduced Neuronal Size in Posterior Hippocampus of Schizophrenic Patients

1991 • 276 citations

Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjects

1996 • 275 citations

Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods

1993 • 257 citations

Region-Specific Regulation of Glutamic Acid Decarboxylase (GAD) mRNA Expression in Central Stress Circuits

1998 • 247 citations

Basal expression and induction of glutamate decarboxylase GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus

1996 • 244 citations

Hippocampal granule cells express glutamic acid decar☐ylase-67 after limbic seizures in the rat

1995 • 176 citations

Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain

1991 • 170 citations

Similar Time Course Changes in Striatal Levels of Glutamic Acid Decarboxylase and Proenkephalin mRNA Following Dopaminergic Deafferentation in the Rat

1988 • 153 citations

Differences in the subregional and cellular distribution of GABAA receptor binding in the hippocampal formation of schizophrenic brain

1996 • 145 citations

Long term increase of glutamate decarboxylase mRNA in a rat model of temporal lobe epilepsy

1990 • 122 citations

Localization of mRNAs encoding two forms of glutamic acid decarboxylase in the rat hippocampal formation

1994 • 117 citations

Post-mortem changes implicate adenine nucleotides and pyridoxal-5′-phosphate in regulation of brain glutamate decarboxylase

1977 • 94 citations

The Nature of γ-Aminobutyric Acid

1970 • 87 citations

Increased glutamic acid decarboxylase (GAD) mRNA and GAD activity in cerebellar Purkinje cells following lesion-induced increases in cell firing

1990 • 67 citations

Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainic acid

1998 • 58 citations

Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons.

1996 • 57 citations

Distribution of glutamic acid decarboxylase (Mr 67 000) in the basal ganglia of the rat: an immunohistochemical study with a selective cDNA-generated polyclonal antibody

1991 • 57 citations

Castration Decreases Single Cell Levels of mRNA Encoding Glutamic Acid Decarboxylase in the Diagonal Band of Broca and the Sexually Dimorphic Nucleus of the Preoptic Area

1997 • 48 citations

Ontogeny and Tissue Distribution of Human GAD Expression

1996 • 40 citations

Developmental changes in GABA neurons of the rat dentate gyrus: An in situ hybridization and birthdating study

1997 • 38 citations

Simultaneous isotopic and nonisotopic in situ hybridization histochemistry with cRNA probes

1998 • 30 citations

Short-term dopaminergic regulation of GABA release in dopamine deafferented caudate-putamen is not directly associated with glutamic acid decarboxylase gene expression

1991 • 28 citations

Relative enrichment of the lighter 59 kDa form of glutamic acid decarboxylase in nerve endings: An immunoblotting study in pituitary neurointermediate lobe

1991 • 18 citations

Localization of Glutamic Acid Decarboxylase in the Kidneys of Nonobese Diabetic Mice

1996 • 14 citations

Partial deafferentation of the developing rat spinal cord delays the spontaneous repression of GAD67 mRNAs in spinal cells.

1998 • 13 citations

Glutamic Acid Decarboxylase (GAD 67) Gene Expression in the Pancreas and Brain of the Nonobese Diabetic Mouse

1996 • 6 citations