A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice.

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

1990 • 2,630 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Cloning and expression of a rat D2 dopamine receptor cDNA

1988 • 1,125 citations

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

Multiple dopamine D4 receptor variants in the human population

1992 • 967 citations

Sequence Alignment of the G-Protein Coupled Receptor Superfamily

1992 • 847 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

The dopamine D2 receptor: two molecular forms generated by alternative splicing.

1989 • 596 citations

Cloning of the cDNA and gene for a human D2 dopamine receptor.

1989 • 488 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

1992 • 470 citations

Transmembrane Protein Structure: Spin Labeling of Bacteriorhodopsin Mutants

1990 • 465 citations

A collision gradient method to determine the immersiondepth of nitroxides in lipid bilayers: application to spin-labeled mutants ofbacteriorhodopsin.

1994 • 411 citations

Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.

1988 • 409 citations

Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.

1990 • 320 citations

Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates

1994 • 255 citations

Determinants of visual pigment absorbance: role of charged amino acids in the putative transmembrane segments

1990 • 228 citations

Role of extracellular disulfide-bonded cysteines in the ligand binding function of the .beta.2-adrenergic receptor

1990 • 215 citations

Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride.

1989 • 208 citations

Determination of transmembrane protein structure by disulfide cross-linking: the Escherichia coli Tar receptor.

1992 • 198 citations

Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase.

1991 • 185 citations

Site-directed mutagenesis of the human dopamine D2 receptor

1992 • 165 citations

Site-directed Mutagenesis of β-Adrenergic Receptors

1989 • 155 citations

Site-directed mutagenesis of colicin E1 provides specific attachment sites for spin labels whose spectra are sensitive to local conformation

1989 • 147 citations

Amino acid residues lining the chloride channel of the cystic fibrosis transmembrane conductance regulator.

1994 • 146 citations

Structure of a bacterial sensory receptor. A site-directed sulfhydryl study.

1988 • 131 citations

Contributions of Conserved Serine Residues to the Interactions of Ligands with Dopamine D2 Receptors

1992 • 123 citations

Use of site-directed fluorescence labeling to study proximity relationships in the lactose permease of Escherichia coli

1993 • 113 citations

Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution.

1993 • 112 citations

Dopamine D2 receptors selectively labeled by a benzamide neuroleptic: [3H]-YM-09151-2

1985 • 108 citations

Alteration of the pH-dependent ion selectivity of the colicin E1 channel by site-directed mutagenesis.

1990 • 50 citations

Evidence for essential thiol groups and disulfide bonds in agonist and antagonist binding to the dopamine receptor

1980 • 48 citations

Effects of heavy metal cations, sulfhydryl reagents and other chemical agents on striatal D2 dopamine receptors

1985 • 43 citations

Influence of Sodium and Sulphydryl Groups on [³H]Sulpiride Binding Sites in Rat Striatal Membranes

1982 • 41 citations

Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides.

1982 • 38 citations

Expression and Characterization of Human Dopamine D₂Receptor in Baculovirus-Infected Insect Cells

1994 • 18 citations

Importance of thiol groups in ligand binding to D2 dopamine receptors from brain and anterior pituitary gland

1992 • 9 citations