Mapping the Binding Site Pocket of the Serotonin 5-Hydroxytryptamine2A Receptor

[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors

1995 • 2,811 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

1988 • 533 citations

Identification of residues required for ligand binding to the beta-adrenergic receptor.

1987 • 398 citations

Adrenergic Receptors as Models for G Protein-Coupled Receptors

1992 • 340 citations

Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function.

1989 • 258 citations

Intrahelical hydrogen bonding of serine, threonine and cysteine residues within α-helices and its relevance to membrane-bound proteins

1984 • 242 citations

Hydrogen bonds involving sulfur atoms in proteins

1991 • 240 citations

Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists.

1991 • 221 citations

Related Contribution of Specific Helix 2 and 7 Residues to Conformational Activation of the Serotonin 5-HT2A Receptor

1995 • 217 citations

Serotonin receptor subtypes : basic and clinical aspects

1991 • 217 citations

Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes

1991 • 168 citations

The role of conserved aspartate and serine residues in ligand binding and in function of the 5‐HT_1A receptor: A site‐directed mutation study

1992 • 164 citations

Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation.

1993 • 138 citations

A Single Amino Acid Substitution in the β-Adrenergic Receptor Promotes Partial Agonist Activity from Antagonists

1989 • 134 citations

A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors.

1993 • 113 citations

Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines.

1994 • 100 citations

Differential ergoline and ergopeptine binding to 5-hydroxytryptamine2A receptors: ergolines require an aromatic residue at position 340 for high affinity binding.

1995 • 86 citations

Signal transduction by a 5-HT2 receptor: a mechanistic hypothesis from molecular dynamics simulations of the three-dimensional model of the receptor complexed to ligands

1993 • 84 citations

Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor

1994 • 56 citations

Polarity conserved positions in transmembrane domains of G-protein coupled receptors and bacteriorhodopsin

1994 • 47 citations

Identification of receptor domains that modify ligand binding to 5-hydroxytryptamine2 and 5-hydroxytryptamine1c serotonin receptors.

1992 • 47 citations

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