Combinatorial protein reagents to manipulate protein function

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

Yeast surface display for screening combinatorial polypeptide libraries

1997 • 1,668 citations

In vitroselection and evolution of functional proteins by using ribosome display

1997 • 1,054 citations

RNA-peptide fusions for the in vitro selection of peptides and proteins

1997 • 1,030 citations

MAP Kinase Pathways in the Yeast Saccharomyces cerevisiae

1998 • 939 citations

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

1999 • 469 citations

Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2

1996 • 444 citations

In vitro virus: Bonding of mRNA bearing puromycin at the 3′‐terminal end to the C‐terminal end of its encoded protein on the ribosome in vitro

1997 • 437 citations

Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

1996 • 380 citations

Peptide Antagonists of the Human Estrogen Receptor

1999 • 372 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators.

1994 • 306 citations

TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE DEVELOPMENT AND FUNCTION

1999 • 293 citations

Ribosome display efficiently selects and evolves high-affinity antibodiesin vitrofrom immune libraries

1998 • 287 citations

Yeast forward and reverse 'n'-hybrid systems

1999 • 261 citations

Expression of Thioredoxin Random Peptide Libraries on the Escherichia coli Cell Surface as Functional Fusions to Flagellin: A System Designed for Exploring Protein-Protein Interactions

1995 • 254 citations

Strategies for selection of antibodies by phage display

1998 • 245 citations

Peptidomimetic design

1998 • 239 citations

Clonal selection and in vivo quantitation of protein interactions with protein-fragment complementation assays

1999 • 228 citations

Phage-display technology – finding a needle in a vast molecular haystack

1999 • 201 citations

The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes

1996 • 201 citations

Genetic Selection of Peptide Inhibitors of Biological Pathways

1999 • 190 citations

Identification of novel mdm2 binding peptides by phage display.

1996 • 181 citations

Bacterial surface display: trends and progress

1997 • 179 citations

An in vivo library-versus-library selection of optimized protein–protein interactions

1999 • 161 citations

Green fluorescent protein as a scaffold for intracellular presentation of peptides

1998 • 156 citations

Protein-peptide interactions analyzed with the yeast two-hybrid system

1995 • 153 citations

Recent advances in producing and selecting functional proteins by using cell-free translation

1998 • 153 citations

Innovative strategies for the oral delivery of drugs and peptides

1998 • 131 citations

The structural basis of phage display elucidated by the crystal structure of the N-terminal domains of g3p

1998 • 131 citations

An artificial cell-cycle inhibitor isolated from a combinatorial library

1998 • 111 citations

Totally in vitro protein selection using mRNA-protein fusions and ribosome display

1999 • 108 citations

“Mutagenesis” by peptide aptamers identifies genetic network members and pathway connections

1999 • 103 citations

Mutagenesis and selection of PDZ domains that bind new protein targets

1999 • 86 citations

Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity

1999 • 84 citations

Targeting cyclin-dependent kinases in Drosophila with peptide aptamers

1998 • 84 citations

Transdominant genetic analysis of a growth control pathway

1998 • 78 citations

Direct demonstration of MuSK involvement in acetylcholine receptor clustering through identification of agonist ScFv

1997 • 65 citations

Cells that register logical relationships among proteins

1997 • 60 citations

The impact of two-hybrid and related methods on biotechnology

1998 • 49 citations

ペプチドアプタマーによる”変異原性”は遺伝的ネットワークメンバーと経路連結性を特定する

1999 • 40 citations

Dimerization of zinc fingers mediated by peptides evolved in vitro from random sequences

1999 • 38 citations

In pursuit of new developments for gene therapy of human diseases

1999 • 29 citations

Genetic selection of short peptides that support protein oligomerization in vivo

1999 • 24 citations

Epitopes fused to F-pilin are incorporated into functional recombinant pili

1998 • 14 citations