Role of the human papillomaviruses in human cancer.

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

1984 • 1,308 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

1987 • 760 citations

Human Papillomaviruses and Their Possible Role in Squamous Cell Carcinomas

1977 • 708 citations

Heterogeneity of the human papillomavirus group

1989 • 677 citations

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

1986 • 665 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

1985 • 600 citations

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

1991 • 592 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

The Physical State of Human Papillomavirus Type 16 DNA in Benign and Malignant Genital Tumours

1985 • 480 citations

Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.

1986 • 440 citations

Condylomatous lesions of the cervix and vagina. I. Cytologic patterns.

1976 • 439 citations

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

1987 • 351 citations

A novel type of human papillomavirus associated with genital neoplasias

1986 • 324 citations

The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.

1990 • 323 citations

Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.

1983 • 313 citations

The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

1987 • 294 citations

Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells.

1988 • 284 citations

Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA

1990 • 270 citations

The Role of Papillomaviruses in Human Anogenital Cancer

1987 • 267 citations

Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters

1990 • 265 citations

Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma.

1988 • 259 citations

Cytology of gynecologic condyloma acuminatum.

1977 • 245 citations

A point mutational analysis of human papillomavirus type 16 E7 protein

1989 • 241 citations

Papillomavirus polypeptides E6 and E7 are zinc-binding proteins

1989 • 239 citations

Herpesvirus Type 2: Association with Carcinoma of the Cervix

1968 • 231 citations

The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes

1989 • 218 citations

ANTIBODIES TO HERPESVIRUS HOMINIS TYPES 1 AND 2 IN HUMANS

1970 • 207 citations

Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix.

1989 • 192 citations

Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells

1989 • 171 citations

Immunoperoxidase localization of papillomavirus antigens in cervical dysplasia and vulvar condylomas

1981 • 157 citations

In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential

1991 • 150 citations

Analysis of human p53 proteins and mRNA levels in normal and transformed cells

1986 • 143 citations

Human cervical cancer as a venereal disease.

1976 • 135 citations

The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.

1988 • 130 citations

Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins

1988 • 124 citations

Prospective study on the relationship between cervical neoplasia and herpes simplex type‐2 virus. II. Herpes simplex type‐2 antibody presence in sera taken at enrolment

1984 • 116 citations

Immortalization of primary rat cells by human papillomavirus type 16 subgenomic DNA fragments controlled by the SV40 promoter

1988 • 112 citations

The E7 protein of human papillomavirus type 16 is phosphorylated by casein kinase II.

1989 • 97 citations

The Significance of a Wish

1991 • 94 citations

The significance of noncondylomatous wart virus infection of the cervical transformation zone. A review with discussion of two illustrative cases.

1978 • 92 citations

Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. I. Epidemiological characteristics

1984 • 80 citations

Identification of a transforming gene of human papillomavirus type 16

1989 • 72 citations

Transforming collaborations between ras and nuclear oncogenes.

1990 • 70 citations

Transformation of rat 3Y1 cells by human papillomavirus type‐18 DNA

1988 • 56 citations

The prevalence of human papillomavirus antigen in patients with cervical intraepithelial neoplasia

1983 • 52 citations

Herpes simplex virus in human genital cancer.

1983 • 50 citations

Role of the human papillomavirus oncoproteins in transformation and carcinogenic progression.

1991 • 20 citations