Cytokines in neural regeneration

Interleukin-6: An Overview

1990 • 1,910 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

The Transforming Growth Factor-βs

1991 • 882 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.

1991 • 677 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

1992 • 559 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation

1992 • 486 citations

Neuropoietic cytokines in the hematopoietic fold

1991 • 474 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor

1991 • 448 citations

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

1992 • 381 citations

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

1992 • 370 citations

Basic FGF in adult rat brain: cellular distribution and response to entorhinal lesion and fimbria-fornix transection

1992 • 367 citations

Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration.

1992 • 365 citations

Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice

1990 • 364 citations

Localization and actions of transforming growth factor-βs in the embryonic nervous system

1991 • 360 citations

Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain.

1991 • 346 citations

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685]

1991 • 310 citations

Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures

1991 • 304 citations

Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system

1991 • 303 citations

A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury

1992 • 289 citations

Receptors for interleukin-1 (α and β) in mouse brain: Mapping and neuronal localization in hippocampus

1991 • 269 citations

Cholinergic differentiation factor (CDF/LIF) promotes survival of isolated rat embryonic motoneurons in vitro

1992 • 246 citations

Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes

1991 • 245 citations

Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF.

1991 • 222 citations

Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.

1990 • 221 citations

Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS

1992 • 213 citations

Cell-type-specific regulation of nerve growth factor (NGF) synthesis in non-neuronal cells: comparison of Schwann cells with other cell types

1991 • 211 citations

Cytokine Regulation of Neuronal Survival

1992 • 209 citations

Localization of basic fibroblast growth factor and its mRNA after CNS injury

1991 • 208 citations

Generation of sensory neurons is stimulated by leukemia inhibitory factor.

1991 • 208 citations

Nuclear and cytoplasmic localization of basic fibroblast growth factor in astrocytes and CA2 hippocampal neurons

1992 • 192 citations

Basic Fibroblast Growth Factor Prevents Thalamic Degeneration after Cortical Infarction

1991 • 191 citations

Prominent expression of acidic fibroblast growth factor in motor and sensory neurons

1991 • 189 citations

Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo

1990 • 184 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures.

1991 • 182 citations

Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain

1991 • 176 citations

Hypoxia-ischemia induces transforming growth factor β1 mRNA in the infant rat brain

1992 • 173 citations

EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture

1991 • 173 citations

Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease

1991 • 167 citations

Immunolocalization of ciliary neuronotrophic factor in adult rat sciatic nerve

1992 • 167 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures

1991 • 164 citations

Acidic and basic fibroblast growth factors in the nervous system: distribution and differential alteration of levels after injury of central versus peripheral nerve

1991 • 161 citations

Regulation by Interleukin‐1 of Nerve Growth Factor Secretion and Nerve Growth Factor mRNA Expression in Rat Primary Astroglial Cultures

1991 • 153 citations

Cytokine regulation of substance P expression in sympathetic neurons.

1991 • 142 citations

Expression of acidic and basic fibroblast growth factors in the substantia nigra of rat, monkey, and human.

1991 • 139 citations

The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?

1992 • 135 citations

Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes.

1991 • 123 citations

Developmental and regional expression of basic fibroblast growth factor mRNA in the rat central nervous system

1990 • 115 citations

Increase in basic fibroblast growth factor-like immunoreactivity in rat brain after forebrain ischemia

1991 • 115 citations

Expression of acidic fibroblast growth factor mRNA in the developing and adult rat brain

1991 • 113 citations

Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain

1991 • 111 citations

Identification of functional receptors for ciliary neurotrophic factor on neuronal cell lines and primary neurons

1990 • 108 citations

The expression of CNTF message and immunoreactivity in the central and peripheral nervous system of the rat

1992 • 106 citations

Basic FGF‐like immunoreactivity in the developing and adult rat brainstem

1991 • 102 citations

Fibroblast growth factor receptor‐bearing neurons in the CNS: Identification by receptor‐mediated retrograde transport

1991 • 100 citations

Survival in vitro of motoneurons identified or purified by novel antibodybased methods is selectively enhanced by muscle-derived factors

1991 • 99 citations

Basic fibroblast growth factor in the hypoglossal system: Specific retrograde transport, trophic, and lesion‐related responses

1992 • 97 citations

Recombinant Human and Rat Ciliary Neurotrophic Factors

1991 • 96 citations

The Fibroblast Growth Factors: An Emerging Family of Neural Growth Factors

1991 • 96 citations

Cytokines and neurokines: related ligands and related receptors

1992 • 95 citations

Epidermal growth factor exerts neuronotrophic effects on dopaminergic and GABAergic CNS neurons: Comparison with basic fibroblast growth factor

1991 • 94 citations

Alpha 2‐macroglobulin synthesis in interleukin‐6‐stimulated human neuronal (SH‐SY5Y neuroblastoma) cells Potential significance for the processing of Alzheimer β‐amyloid precursor protein

1991 • 93 citations

Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development

1991 • 86 citations

Effects of ciliary neuronotrophic factor on rat spinal cord neurons in vitro: survival and expression of choline acetyltransferase and low-affinity nerve growth factor receptors

1991 • 84 citations

Internalization and processing of basic fibroblast growth factor by neurons and astrocytes

1991 • 83 citations

Increases in transforming growth factor‐β mRNA in hippocampus during response to entorhinal cortex lesions in intact and adrenalectomized rats

1991 • 82 citations

Developmental expression of the basic fibroblast growth factor gene in rat brain

1991 • 81 citations

Basic FGF is present in dopaminergic neurons of the ventral midbrain of the rat

1991 • 80 citations

Mechanism of nerve growth factor mRNA regulation by interleukin-1 and basic fibroblast growth factor in primary cultures of rat astrocytes.

1991 • 78 citations

Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia

1991 • 72 citations

The Fibroblast Growth Factor Family An Overview

1991 • 72 citations

Peripheral nerve regeneration is impeded by interleukin‐1 receptor antagonist released from a polymeric guidance channel

1991 • 70 citations

Stimulation of neuron survival by basic FGF and CNTF is a direct effect and not mediated by non-neuronal cells: evidence from single cell cultures

1992 • 66 citations

Interleukin‐2 enhances chick and rat sympathetic, but not sensory, neurite outgrowth

1990 • 65 citations

Basic fibroblast growth factor regulates the ability of astrocytes to support hypothalamic neuronal survival in vitro

1991 • 63 citations

Sequence and structural organization of the human gene encoding ciliary neurotrophic factor

1991 • 63 citations

Neurotrophic factors in regeneration

1991 • 61 citations

Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease.

1991 • 60 citations

Peripheral nerve injury down‐regulates CNTF expression in adult rat sciatic nerves

1992 • 54 citations

Fibroblast Growth Factors: Their Roles in the Central and Peripheral Nervous System

1993 • 53 citations

Decreased synthesis of ciliary neurotrophic factor in degenerating peripheral nerves

1992 • 49 citations

Further Studies of the Distribution of CDF/LIF mRNA

2007 • 47 citations

The binding of basic fibroblast growth factor to Alzheimer's neurofibrillary tangles and senile plaques

1991 • 47 citations

Interleukin 1 expression is inducible by nerve growth factor in PC12 pheochromocytoma cells.

1991 • 45 citations

Localization of basic fibroblast growth factor in a subpopulation of rat sensory neurons

1992 • 42 citations

Appearance of nerve growth factor and acidic fibroblast growth factor with different time courses in the cavity-lesioned cortex of the rat brain

1991 • 41 citations

Effect of CNTF on low‐affinity NGF receptor expression by cultured neurons from different rat brain regions

1991 • 38 citations

Synthesis, purification, and characterization of human ciliary neuronotrophic factor from E. coli

1991 • 37 citations

Biochemistry and Molecular Biology of Fibroblast Growth Factors

1993 • 34 citations

Acidic fibroblast growth factor-like immunoreactivity in brain of Alzheimer patients

1991 • 34 citations

Recombinant human basic fibroblast growth factor (rhbFGF) induces secretion of nerve growth factor (NGF) in cultured rat astroglial cells

1991 • 33 citations

Basic Fibroblast Growth Factor in Neurons and Its Putative Functions^a

1991 • 32 citations

Interleukin-1α expression is inducible by cholinergic stimulation in the rat adrenal gland

1992 • 29 citations

The use of the optical disector to estimate the total number of neurons in the developing chick lateral motor column: Effects of purified growth factors

1991 • 29 citations

Basic fibroblast growth factor promotes transmitter storage and synthesis in cultured chromaffin cells

1992 • 27 citations

Molecular mechanisms for generation of neural diversity and specificity: roles of polypeptide factors in development of postmitotic neurons

1992 • 27 citations

Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli

1991 • 27 citations

Antibodies to interleukin-1 inhibit cytokine-induced proliferation of neonatal rat Schwann cells in vitro

1991 • 26 citations

Regulation of neural cell survival and differentiation by peptide growth factors

1990 • 26 citations

Stimulation of biosynthesis of nerve growth factor by acidic fibroblast growth factor in cultured mouse astrocytes

1991 • 25 citations

Fibroblast growth factor-induced increased survival of chollnergic mesopontine neurons in culture

1991 • 23 citations

CNTF rescues motoneurons from ontogenetic cell death in-vivo, but not in-vitro

1990 • 21 citations

FGFs stimulate IGF binding protein synthesis without affecting IGF synthesis in rat astroblasts in primary culture

1991 • 20 citations

A ciliary neuronotrophic factor from peripheral nerve and smooth muscle which is not retrogradely transported

1991 • 19 citations

Co‐activation of insulin‐like growth factor‐I receptors and protein kinase C results in parasympathetic neuronal survival

1991 • 18 citations

Failure of basic fibroblast growth factor to prevent postischemic neuronal damage in the rat

1991 • 18 citations

Insulin‐Like Growth Factor‐I Enhances Tyrosine Hydroxylase Activation in Bovine Chromaffin Cells

1991 • 16 citations

Tissue- and development-specific expression of HBGF-1 mRNA

1991 • 9 citations

Retinoic acid potentiates the neurotrophic but not the mitogenic action of the class 1 heparin-binding growth factor (HBGF-1)

1991 • 8 citations