Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease

2001 • 2,290 citations

Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

2003 • 1,275 citations

Experience-Induced Neurogenesis in the Senescent Dentate Gyrus

1998 • 1,135 citations

TRANSPLANTATION OF EMBRYONIC DOPAMINE NEURONS FOR SEVERE PARKINSON'S DISEASE

2001 • 1,013 citations

Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

1996 • 943 citations

Activity-dependent neuronal plasticity following tissue injury and inflammation

1992 • 933 citations

Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD

2003 • 804 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1995 • 608 citations

Circulating Insulin-Like Growth Factor I Mediates the Protective Effects of Physical Exercise against Brain Insults of Different Etiology and Anatomy

2001 • 593 citations

Animal models of anxiety and depression: how are females different?

2001 • 547 citations

Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain

2000 • 538 citations

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1997 • 460 citations

Differential rearing effects on rat visual cortex synapses. I. Synaptic and neuronal density and synapses per neuron

1985 • 459 citations

Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease

2003 • 401 citations

Effects of rearing complexity on dendritic branching in frontolateral and temporal cortex of the rat

1973 • 377 citations

Dopamine transporters and neuronal injury

1999 • 376 citations

Differential rearing effects on rat visual cortex synapses.

1987 • 373 citations

Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus

2000 • 362 citations

Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus

1998 • 360 citations

Dopamine Transporter Is Required for In Vivo MPTP Neurotoxicity: Evidence from Mice Lacking the Transporter

1997 • 358 citations

Differential regulation by exercise of BDNF and NT‐3 in rat spinal cord and skeletal muscle

2001 • 357 citations

Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine

2001 • 355 citations

Exercise‐induced behavioral recovery and neuroplasticity in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐lesioned mouse basal ganglia

2004 • 298 citations

Physical exercise induces FGF-2 and its mRNA in the hippocampus

1997 • 286 citations

Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys

2002 • 284 citations

Relations between brain chemistry and problem-solving among rats raised in enriched and impoverished environments.

1962 • 272 citations

Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains

2002 • 262 citations

Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle

1999 • 252 citations

IV. MPTP, MPP+ and mitochondrial function

1987 • 249 citations

Physical therapy and Parkinson's disease

1994 • 238 citations

Absence of MPTP-Induced Neuronal Death in Mice Lacking the Dopamine Transporter

1999 • 226 citations

A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment

2003 • 211 citations

Enriched Environment Confers Resistance to 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine and Cocaine: Involvement of Dopamine Transporter and Trophic Factors

2003 • 209 citations

Effects of environmental enrichment and impoverishment on rat cerebral cortex

1972 • 208 citations

Can the brain be protected through exercise? Lessons from an animal model of parkinsonism☆

2003 • 206 citations

Insulin-like Growth Factor-1-mediated Neuroprotection against Oxidative Stress Is Associated with Activation of Nuclear Factor κB

1999 • 205 citations

Increased MPTP Neurotoxicity in Vesicular Monoamine Transporter 2 Heterozygote Knockout Mice

1998 • 177 citations

Age-Dependent Differences in the Effects of GDNF and NT-3 on the Development of Neurons and Glia from Neural Crest-Derived Precursors Immunoselected from the Fetal Rat Gut: Expression of GFRα-1in Vitroandin Vivo

1998 • 175 citations

Effects of complex or isolated environments on cortical dendrites of middle-aged rats

1983 • 169 citations

Measurement of the dopaminergic degeneration in Parkinson's disease with [123I] beta-CIT and SPECT. Correlation with clinical findings and comparison with multiple system atrophy and progressive supranuclear palsy.

1997 • 165 citations

Neuroprotective and neurorestorative properties of GDNF

1998 • 157 citations

Glial Cell Line-Derived Neurotrophic Factor Is Essential for Postnatal Survival of Midbrain Dopamine Neurons

2000 • 156 citations

Measurement of the dopaminergic degeneration in Parkinson’s disease with [123I]β-CIT and SPECT

1997 • 155 citations

Effect of exercise on perceived quality of life of individuals with Parkinson's disease.

2001 • 154 citations

Increased Density of Multiple-Head Dendritic Spines on Medium-Sized Spiny Neurons of the Striatum in Rats Reared in a Complex Environment

1996 • 145 citations

Distribution of the neurotrophins brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the postnatal rat brain: an immunocytochemical study

1998 • 141 citations

Differential strain susceptibility following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration acts in an autosomal dominant fashion: quantitative analysis in seven strains of Mus musculus

1999 • 140 citations

Localization of Insulin-Like Growth Factor-I mRNA in Rat Brain byin SituHybridization—Relationship to IGF-I Receptors

1990 • 140 citations

Effects of Brain-derived Neurotrophic Factor on 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in Monkeys

1995 • 138 citations

Epidemiology of Parkinsonʼs disease and akinetic syndromes

2000 • 135 citations

Animal Models of PD

2002 • 133 citations

Therapeutic value of exercise training in Parkinson???s disease

1999 • 133 citations

Environmental complexity modulates growth of granule cell dendrites in developing but not adult hippocampus of rats

1978 • 132 citations

Pathophysiologic basis of surgery for Parkinson's disease.

2000 • 126 citations

Effect of the richness of the environment on the cat visual cortex

1987 • 101 citations

Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression

1999 • 100 citations

Voluntary Running Provides Neuroprotection in Rats After 6-Hydroxydopamine Injection into the Medial Forebrain Bundle

2004 • 90 citations

MPP+-induced efflux of dopamine and lactate from rat striatum have similar time courses as shown by in vivo brain dialysis.

1988 • 89 citations

Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata.

2000 • 86 citations

The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease.

1986 • 86 citations

Peptide inhibitors of caspase-3-like proteases attenuate MPP+ -induced toxicity of cultured fetal rat mesencephalic dopamine neurons

1998 • 78 citations

Co-expression of mRNA for Neurotrophic Factors in Human Neurons and Glial Cells in Culture

1994 • 77 citations

Studies on the toxicity of 1-methyl-4-phenylpyridinium ion (MPP+) against mitochondria of mouse brain

1988 • 68 citations

Long-term effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal dopamine content in young and mature mice

1987 • 59 citations

Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets

2001 • 57 citations

Oxidative stress, age-related neurodegeneration, and the potential for neurotrophic treatment.

1995 • 57 citations

GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice

1998 • 54 citations

Features of the Dopaminergic Neurotoxin MPTP

1992 • 54 citations

Protection against dopaminergic nigrostriatal cell death by excitatory input ablation

2000 • 52 citations

Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice

1998 • 52 citations

Strain‐dependent susceptibility to MPTP and MPP⁺‐induced Parkinsonism is determined by glia

2001 • 51 citations

Time-course and dose–response study on the effects of chronic l-DOPA administration on striatal dopamine levels and dopamine transporter following MPTP toxicity

2000 • 42 citations

Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping

2002 • 39 citations

Regulation of heme oxygenase-1 expression by dopamine in cultured C6 glioma and primary astrocytes

1999 • 37 citations

Neuroprotection for Parkinson's disease using viral vector-mediated delivery of GDNF

2002 • 34 citations

Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice

2003 • 29 citations

Are Human Neurodegenerative Disorders Linked to Environmental Chemicals with Excitotoxic Properties?^a

1992 • 29 citations

Method for culturing postnatal substantia nigra as an in vitro model of experimental Parkinson’s disease

2002 • 29 citations

Nigral neurons are likely to die of a mechanism other than classical apoptosis in Parkinson's disease

1999 • 21 citations

Relevance of different striatal markers in assessment of the MPP⁺‐induced dopaminergic nigrostriatal injury in rat

2002 • 18 citations

Cortical depth changes in enriched and isolated mice

1982 • 17 citations

New insights on the pathogenesis of neurodegenerative disorders.

1992 • 4 citations