Nigral neurons are likely to die of a mechanism other than classical apoptosis in Parkinson's disease

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1995 • 1,171 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

Mitochondria as regulators of apoptosis: doubt no more

1998 • 838 citations

Greenfield's Neuropathology

1997 • 811 citations

The central executioners of apoptosis: caspases or mitochondria?

1998 • 772 citations

Online Mendelian Inheritance in Man

1998 • 767 citations

A cautionary note on the use of the TUNEL stain to determine apoptosis

1995 • 490 citations

Histochemical detection of apoptosis in Parkinson's disease

1996 • 448 citations

Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease

1998 • 426 citations

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

1995 • 350 citations

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

1998 • 313 citations

Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons.

1997 • 286 citations

Alzheimer Disease

1998 • 211 citations

A fluorescent double‐labeling method to detect and confirm apoptotic nuclei in parkinson's disease

1998 • 198 citations

P53- and CD95-associated apoptosis in neurodegenerative diseases.

1998 • 196 citations

Surveillance, Intervention and Cytotoxicity: Is There a Protective Role of Microglia?

1994 • 185 citations

Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain

1997 • 173 citations

Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family

1998 • 146 citations

On the question of apoptosis in the parkinsonian substantia nigra

1997 • 145 citations

Programmed cell death: Does it play a role in parkinson's disease?

1998 • 103 citations

Greenfield's Neuropathology

1963 • 102 citations

DNA fragmentation in human substantia nigra: Apoptosis or perimortem effect?

1998 • 101 citations

Oxidative phosphorylation defects and Alzheimer's disease

1997 • 90 citations

Novel mutations of mitochondrial complex I in pathologically proven Parkinson disease

1998 • 88 citations

The causes of parkinson's disease are being unraveled and rational neuroprotective therapy is close to reality

1998 • 79 citations

Population control of microglia: does apoptosis play a role?

1997 • 69 citations

Two novel point mutations of mitochondrial tRNA genes in histologically confirmed Parkinson disease

1999 • 50 citations

Dismantling in Cell Death: Molecular Mechanisms and Relationship to Caspase Activation

1998 • 47 citations

Regional heterogeneity of mtDNA heteroplasmy in parkinsonian brain.

1996 • 41 citations

Neuronal degeneration in amyotrophic lateral sclerosis is mediated by a possible mechanism different from classical apoptosis

1998 • 9 citations

What does apoptosis have to do with Parkinson's disease?

1999 • 8 citations