Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

1998 • 3,973 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

1987 • 2,189 citations

Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex

2000 • 1,224 citations

Dopamine neurons report an error in the temporal prediction of reward during learning

1998 • 1,115 citations

Practice Parameter for the Use of Stimulant Medications in the Treatment of Children, Adolescents, and Adults

2002 • 907 citations

Dopamine Transporter Occupancies in the Human Brain Induced by Therapeutic Doses of Oral Methylphenidate

1998 • 878 citations

Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study

1998 • 844 citations

Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain

2001 • 745 citations

Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration

1998 • 686 citations

Relationship between subjective effects of cocaine and dopamine transporter occupancy

1997 • 653 citations

Effects of Methylphenidate on Extracellular Dopamine, Serotonin, and Norepinephrine: Comparison with Amphetamine

1997 • 613 citations

Is Methylphenidate Like Cocaine?

1995 • 575 citations

Cerebellum in attention-deficit hyperactivity disorder

1998 • 569 citations

Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography

2000 • 517 citations

Opposite Modulation of Cocaine-Seeking Behavior by D ₁ - and D ₂ -Like Dopamine Receptor Agonists

1996 • 493 citations

Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

1977 • 490 citations

Burst firing in midbrain dopaminergic neurons

1997 • 482 citations

Association and Linkage of the Dopamine Transporter Gene and Attention-Deficit Hyperactivity Disorder in Children: Heterogeneity owing to Diagnostic Subtype and Severity

1998 • 467 citations

Metabolic Mapping of Functional Activity in the Hypothalamo-Neurohypophysial System of the Rat

1979 • 464 citations

“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect

2002 • 447 citations

Distribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain

1994 • 408 citations

Prediction of Reinforcing Responses to Psychostimulants in Humans by Brain Dopamine D₂ Receptor Levels

1999 • 406 citations

Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.

1999 • 403 citations

Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.

1989 • 389 citations

Imaging endogenous dopamine competition with [¹¹C]raclopride in the human brain

1994 • 378 citations

Reappraising the cerebellum: What does the hindbrain contribute to the forebrain?

1989 • 369 citations

Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review

2001 • 357 citations

Brain Imaging of Attention Deficit/Hyperactivity Disorder

2001 • 332 citations

Overexpression of dopamine D2 receptors reduces alcohol self‐administration

2001 • 318 citations

Methylphenidate: Its Pharmacology and Uses

2000 • 307 citations

FIXED‐INTERVAL SCHEDULE OF COCAINE REINFORCEMENT: EFFECT OF DOSE AND INFUSION DURATION¹

1973 • 293 citations

Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine

1991 • 292 citations

Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat

1997 • 282 citations

Anti-hyperactivity medication: methylphenidate and amphetamine

1998 • 262 citations

Utility of subjective‐effects measurements in assessing abuse liability of drugs in humans

1991 • 256 citations

Short-term and long-term verbal memory: a positron emission tomography study.

1995 • 255 citations

Comparison between intraperitoneal and oral methylphenidate administration: A microdialysis and locomotor activity study.

2000 • 254 citations

Dopaminergic modulation of glutamate-induced excitations of neurons in the neostriatum and nucleus accumbens of awake, unrestrained rats

1996 • 245 citations

A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey.

1975 • 235 citations

CNS stimulants: two distinct mechanisms of action for amphetamine-like drugs

1983 • 203 citations

Pharmacology of the enantiomers of threo-methylphenidate.

1987 • 192 citations

Experimental approach to individual vulnerability to psychostimulant addiction

1989 • 180 citations

Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain

2000 • 179 citations

Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors

1997 • 174 citations

Chiral drugs: comparison of the pharmacokinetics of [ 11 C] d-threo and l-threo -methylphenidate in the human and baboon brain

1997 • 153 citations

Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens

2001 • 138 citations

Intravenous methylphenidate abuse. Prototype for prescription drug abuse.

1991 • 137 citations

Effects of Stimulant Medication on Learning in Children with ADHD

1991 • 129 citations

Palliative Uses of Methylphenidate in Patients With Cancer: A Review

2002 • 128 citations

Cerebrospinal Fluid Homovanillic Acid Predicts Behavioral Response to Stimulants in 45 Boys with Attention Deficit/Hyperactivity Disorder

1996 • 126 citations

Blockade of striatal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of "high".

1999 • 120 citations

Practice Parameters for the Treatment of Narcolepsy: An Update for 2000

2001 • 120 citations

The distribution of alterations in energy metabolism in the rat brain produced by apomorphine

1982 • 111 citations

Low cerebellar metabolism in medicated patients with chronic schizophrenia

1992 • 71 citations

Behavioral and Cardiovascular Effects of Intravenous Methylphenidate in Normal Subjects and Cocaine Abusers

1997 • 70 citations

Effects of cocaine context on NAcc dopamine and behavioral activity after repeated intravenous cocaine administration

2000 • 63 citations

Acute Handling Stress Modulates Methylphenidate-induced Catecholamine Overflow in the Medial Prefrontal Cortex

2002 • 60 citations

A single injection of either flupenthixol decanoate or haloperidol decanoate produces long-term changes in cocaine self-administration in rats

1994 • 51 citations

Use of Psychostimulants in Medically Ill Patients with Neurological Disease and Major Depression

1984 • 50 citations

Regulation of substantia nigra dopamine neurons.

1994 • 47 citations

Blunted change in cerebral glucose utilization after haloperidol treatment in schizophrenic patients with prominent negative symptoms

1996 • 44 citations

Some Relationships Between Addiction and Drug Delivery to the Brain

1992 • 44 citations

Factors influencing the reinforcing and subjective effects of d-amphetamine in humans.

1993 • 41 citations

Methylphenidate: Increased Abuse or Appropriate Use ?

1999 • 38 citations

Psychiatric pharmacogenetics: personalizing psychostimulant therapy in attention-deficit/hyperactivity disorder

2002 • 31 citations

Dopamine release during cocaine self-administration in rats: effect of SCH23390

1995 • 25 citations

Functional correlates of repeated administration of cocaine and apomorphine in the rat

1995 • 22 citations

Comparison of Methods for the Assessment of Central Nervous System Stimulant Response after Dextroamphetamine Administration to Healthy Male Volunteers

1996 • 21 citations

Methylphenidate: Rate-dependent drug effects in hyperactive boys

1985 • 17 citations

Bioavailability of Drugs to the Brain and the Blood-Brain Barrier

1992 • 14 citations