Methylphenidate: Its Pharmacology and Uses

Diagnostic and Statistical Manual of Mental Disorders

2022 • 16,313 citations

J Neuropsychiatry Clin Neurosci

1992 • 3,756 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

1987 • 2,189 citations

National Institutes of Health Consensus Development Conference Statement: Geriatric Assessment Methods for Clinical Decision‐making

1988 • 1,353 citations

Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents

1998 • 1,095 citations

THE BEHAVIOR OF CHILDREN RECEIVING BENZEDRINE

1937 • 1,033 citations

Association of attention-deficit disorder and the dopamine transporter gene.

1995 • 1,023 citations

Dopamine Transporter Occupancies in the Human Brain Induced by Therapeutic Doses of Oral Methylphenidate

1998 • 878 citations

Role of Serotonin in the Paradoxical Calming Effect of Psychostimulants on Hyperactivity

1999 • 873 citations

Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

1992 • 718 citations

Effects of Methylphenidate on Extracellular Dopamine, Serotonin, and Norepinephrine: Comparison with Amphetamine

1997 • 613 citations

Cloning and Expression of a Cocaine-Sensitive Dopamine Transporter Complementary DNA

1991 • 584 citations

Is Methylphenidate Like Cocaine?

1995 • 575 citations

Depression in Patients With Cancer

1995 • 539 citations

Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism

1997 • 498 citations

A Double-blind, Crossover Comparison of Methylphenidate and Placebo in Adults With Childhood-Onset Attention-Deficit Hyperactivity Disorder

1995 • 423 citations

Increased Methylphenidate Usage for Attention Deficit Disorder in the 1990s

1996 • 419 citations

Treatment of Attention-Deficit–Hyperactivity Disorder

1999 • 409 citations

Methylphenidate therapy improves cognition, mood, and function of brain tumor patients.

1998 • 377 citations

Diagnosis and Treatment of Minimal Brain Dysfunction in Adults

1976 • 354 citations

National Institutes of Health Consensus Development Conference Statement: Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD)

2000 • 321 citations

Effect of Stimulant Medication on Children with Attention Deficit Disorder: A “Review of Reviews”

1993 • 314 citations

Methylphenidate in early poststroke recovery: A double-blind, placebo-controlled study

1998 • 299 citations

A comparison of the capacities of isomers of amphetamine, deoxypipradrol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat cerebral cortex, hypothalamus and striatum and into adrenergic nerves of rabbit aorta.

1972 • 296 citations

Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis1Published on the World Wide Web on 27 January 1998.1

1998 • 265 citations

A controlled study of methylphenidate in the treatment of attention deficit disorder, residual type, in adults

1985 • 264 citations

Anti-hyperactivity medication: methylphenidate and amphetamine

1998 • 262 citations

Relative Efficacy of Long-Acting Stimulants on Children With Attention Deficit-Hyperactivity Disorder: A Comparison of Standard Methylphenidate, Sustained-Release Methylphenidate, Sustained-Release Dextroamphetamine, and Pemoline

1990 • 251 citations

Stimulant Medications Precipitate Tourette's Syndrome

1982 • 246 citations

Apathy: a treatable syndrome

1995 • 236 citations

Growth Deficits in ADHD Children Revisited: Evidence for Disorder-Associated Growth Delays?

1996 • 234 citations

Long-term Methylphenidate Therapy in Children With Comorbid Attention-Deficit Hyperactivity Disorder and Chronic Multiple Tic Disorder

1999 • 234 citations

A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

1992 • 222 citations

Subacute methylphenidate treatment for moderate to moderately severe traumatic brain injury: A preliminary double-blind placebo-controlled study

1996 • 218 citations

Pharmacokinetics of methylphenidate in man, rat and monkey.

1983 • 217 citations

Use of methylphenidate in the treatment of children with autistic disorder

1995 • 215 citations

EFFECTS OF METHYLPHENIDATE ON ATTENTIONAL FUNCTION AFTER TRAUMATIC BRAIN INJURY

1997 • 193 citations

Pharmacology of the enantiomers of threo-methylphenidate.

1987 • 192 citations

Methylphenidate Effects on Symptoms of Attention Deficit Disorder in Adults

1984 • 186 citations

Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain

1999 • 185 citations

Methylphenidate associated with narcotics for the treatment of cancer pain.

1987 • 185 citations

Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: amphetamine specificity for inhibition and efflux.

1995 • 182 citations

The Run on Ritalin: Attention Deficit Disorder and Stimulant Treatment in the 1990s

1996 • 181 citations

Problems in the Management of Attention-Deficit–Hyperactivity Disorder

1999 • 178 citations

Stimulant treatment for the neurobehavioural sequelae of traumatic brain injury

1988 • 172 citations

Sustained Release and Standard Methylphenidate Effects on Cognitive and Social Behavior in Children With Attention Deficit Disorder

1987 • 169 citations

The Stimulants

1992 • 164 citations

Neuropsychological effects of methylphenidate in patients receiving a continuous infusion of narcotics for cancer pain

1992 • 159 citations

Methylphenidate and Growth in Hyperactive Children

1988 • 157 citations

The use of methylphenidate in patients with incident cancer pain receiving regular opiates. A preliminary report

1992 • 157 citations

Hyperactive Boys Almost Grown Up

1988 • 156 citations

Metabolism and disposition of methylphenidate-14C: studies in man and animals.

1974 • 155 citations

Chiral drugs: comparison of the pharmacokinetics of [ 11 C] d-threo and l-threo -methylphenidate in the human and baboon brain

1997 • 153 citations

[³H]Threo‐(±)‐Methylphenidate Binding to 3,4‐Dihydroxyphenylethylamine Uptake Sites in Corpus Striatum: Correlation with the Stimulant Properties of Ritalinic Acid Esters

1985 • 153 citations

Stimulants in the treatment of depression: a critical overview.

1989 • 148 citations

Contrasting actions of pressor agents in severe autonomic failure

1998 • 145 citations

Use of methylphenidate as an adjuvant to narcotic analgesics in patients with advanced cancer

1989 • 143 citations

In vivo neurochemical profile of dopamine uptake inhibitors and releasers in rat caudate-putamen

1989 • 139 citations

Intravenous methylphenidate abuse. Prototype for prescription drug abuse.

1991 • 137 citations

Clinical Effects of Methylphenidate and Thioridazine in Intellectually Subaverage Children

1991 • 135 citations

Methylphenidate augmentation of serotonin selective reuptake inhibitors: a case series.

1996 • 134 citations

Do Typical Clinical Doses of Methylphenidate Cause Tics in Children Treated for Attention-Deficit Hyperactivity Disorder?

1999 • 131 citations

Comparison of inhibition of monoamine uptake by cocaine, methylphenidate and amphetamine.

1978 • 131 citations

USE OF STIMULANTS IN THE MEDICALLY ILL

1996 • 131 citations

Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex

1990 • 128 citations

A randomized, crossover evaluation of methylphenidate in cancer patients receiving strong narcotics

1995 • 121 citations

Psychostimulants for Depression in Hospitalized Cancer Patients

1996 • 121 citations

Enantioselective pharmacokinetics and pharmacodynamics of dl-thero-mcthylphenidate in children with attention deficit hyperactivity disorder

1992 • 120 citations

Methylphenidate for depressive disorders in cancer patients

1987 • 119 citations

Double-blind, placebo-controlled trial of methylphenidate in older, depressed, medically ill patients

1995 • 116 citations

CNS Stimulant Potentiation of Monoamine Oxidase

1991 • 116 citations

Attention Deficit Disorders in Adults

1985 • 116 citations

Methylphenidate Hydrochloride Given With or Before Breakfast: II. Effects on Plasma Concentration of Methylphenidate and Ritalinic Acid

1983 • 115 citations

Withdrawn, Apathetic Geriatric Patients Responsive to Methylphenidate

1975 • 115 citations

Treatment of depression in the medically ill elderly with methylphenidate

1980 • 115 citations

Cognitive Impairment Due to AIDS-Related Complex and Its Response to Psychostimulants

1988 • 114 citations

Methylphenidate effect on attention deficit in the acutely brain-injured adult

1996 • 112 citations

Effect of methylphenidate on brain injury-related anger.

1993 • 111 citations

A double-blind controlled study of methylphenidate treatment in closed head injury

1993 • 110 citations

Enantioselective pharmacokinetics of dl-threo-methylphenidate in humans.

1993 • 105 citations

Psychopharmacology of Attention Deficit Disorder: Pharmacokinetic, Neuroendocrine, and Behavioral Measures Following Acute and Chronic Treatment with Methylphenidate

1982 • 104 citations

Treatment of Chronic Closed Head Injury with Psychostimulant Drugs: A Controlled Case Study and an Appropriate Evaluation Procedure

1987 • 101 citations

Methylphenidate and seizure frequency in brain injured patients with seizure disorders.

1992 • 99 citations

Methylphenidate treatment of negative symptoms in patients with dementia

1997 • 98 citations

Sustained Release Methylphenidate: Pharmacokinetic Studies in ADDH Males

1989 • 98 citations

Narcolepsy

1990 • 98 citations

Anxiety and stigmatizing aspects of HIV infection.

1989 • 95 citations

Short communication

1998 • 94 citations

Intravenous Methylphenidate Abuse

1991 • 94 citations

Treatment of Narcolepsy: Objective Studies on Methylphenidate, Pemoline, and Protriptyline

1986 • 94 citations

Efficacy of Methylphenidate Among Mentally Retarded Children With Attention Deficit Hyperactivity Disorder

1990 • 93 citations

Pharmacologic Treatment of Attention Deficit Hyperactivity Disorder

1992 • 91 citations

The central stimulatory action of inhibitors of the dopamine uptake

1979 • 90 citations

Effects and Noneffects of Methylphenidate in Children with Mental Retardation and ADHD

1992 • 90 citations

Methylphenidate in the treatment of neurobehavioral slowing associated with cancer and cancer treatment

1995 • 88 citations

Psychopharmacology of ADHD: children and adolescents.

1998 • 87 citations

Characterisation of methylphenidate and nomifensine induced dopamine release in rat striatum using in vivo brain microdialysis

1991 • 87 citations

Psychostimulants for Secondary Depression in Medical Illness

1991 • 87 citations

Effects of Sustained-Release and Standard Preparations of Methylphenidate on Attention Deficit Disorder

1992 • 84 citations

Single‐Dose Pharmacokinetics of Modafinil and Methylphenidate Given Alone or in Combination in Healthy Male Volunteers

1998 • 81 citations

Pharmacotherapy of attention-deficit/hyperactivity disorder in adults.

1998 • 80 citations

Effects of Methylphenidate in HIV-Related Depression: A Comparative Trial with Desipramine

1995 • 80 citations

Potentiation of Opioid Analgesia by Psychostimulant Drugs

1998 • 79 citations

A Fatality Due to the Intranasal Abuse of Methylphenidate (Ritalin®)

1999 • 78 citations

Pharmacokinetics of methylphenidate in hyperkinetic children.

1979 • 78 citations

Methylphenidate and nortriptyline in the treatment of poststroke depression: A retrospective comparison

1994 • 76 citations

Neuropharmacologic treatment of hemineglect: A case report comparing bromocriptine and methylphenidate

1998 • 76 citations

Recovery in Pediatric Brain Injury: Is Psychostimulant Medication Beneficial?

1998 • 76 citations

Pharmacokinetics and in vivo specificity of [^LLC]dl‐threo‐methylphenidate for the presynaptic dopaminergic neuron

1994 • 75 citations

Blockade by reserpine of methylphenidate-induced release of brain dopamine.

1975 • 74 citations

Diagnosis and treatment of depression in the cancer patient.

1984 • 73 citations

Dextroamphetamine or methylphenidate as adjuvants to opioid analgesia for adolescents with cancer

1994 • 70 citations

Pharmacotherapy of Attention Deficit Hyperactivity Disorder in Adults

1998 • 70 citations

Prader-Willi Syndrome

1998 • 69 citations

Methylphenidate and thioridazine in the treatment of intellectually subaverage children: Effects on cognitive-motor performance

1991 • 69 citations

The effects of surgical and chemical lesions on striatal binding: Correlation with [3H]dopamine uptake

1985 • 64 citations

Long-term follow-up of children with mental retardation/borderline intellectual functioning and ADHD.

1997 • 63 citations

Temporal relationships between the pharmacokinetics of methylphenidate in the human brain and its behavioral and cardiovascular effects

1996 • 60 citations

Successful Treatment of Giggle Incontinence With Methylphenidate

1996 • 59 citations

Methylphenidate in treating poststroke depression.

1988 • 59 citations

Successful treatment of giggle incontinence with methylphenidate.

1996 • 58 citations

The use of methylphenidate in paediatric traumatic brain injury

1997 • 58 citations

Effects of CNS stimulants on the in vivo release of the colocalized transmitters, dopamine and neurotensin, from rat prefrontal cortex

1992 • 57 citations

Prediction of Response to Methylphenidate among Children with ADHD and Mental Retardation

1994 • 57 citations

METHYLPHENIDATE IN STROKE PATIENTS WITH DEPRESSION

1992 • 55 citations

Analeptic Use in Clinical Toxicology: A Historical Appraisal

1997 • 53 citations

Enantioselective Aspects of the Disposition of dl-threo-Methylphenidate after the Administration of a Sustained-Release Formulation to Children with Attention Deficit-Hyperactivity Disorder

1989 • 53 citations

Methylphenidate in depressed medically ill patients.

1991 • 52 citations

Investigations into the correlations between monoamine oxidase inhibition and other effects due to methylphenydate and its stereoisomers

1961 • 51 citations

Current Drug Therapy Recommendations for the Treatment of Attention Deficit Hyperactivity Disorder

1998 • 50 citations

Use of Psychostimulants in Medically Ill Patients with Neurological Disease and Major Depression

1984 • 50 citations

Kinetic Analysis of Enantiomers of Threo-Methylphenidate and Its Metabolite in Two Healthy Subjects after Oral Administration as Determined by a Gas Chromatographic-Mass Spectrometric Method

1990 • 50 citations

SUCCESSFUL TREATMENT OF POST-TRAUMATIC NARCOLEPSY WITH METHYLPHENIDATE

1996 • 47 citations

Effects of methylphenidate on early adolescent growth

1990 • 46 citations

Methylphenidate treatment of patients with head and neck cancer

1986 • 44 citations

Treatment of Children With Williams Syndrome With Methylphenidate

1997 • 42 citations

Brief report: response to methylphenidate in two children with Williams syndrome.

1997 • 40 citations

Treatment of ADDH in Mentally Retarded Children: A Preliminary Study

1989 • 39 citations

Efficacy of Methylphenidate and Behavioral Intervention on Classroom Behavior in Children with ADHD and Mental Retardation

1994 • 39 citations

A study of methylphenidate in man with respect to its major metabolite.

1982 • 38 citations

The effect of methylphenidate on test performance in the cognitively impaired aged

1977 • 38 citations

Pharmacokinetics and pharmacodynamics of methylphenidate enantiomers in rats

1996 • 37 citations

Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy volunteers

1993 • 37 citations

Neuropsychiatric Sequelae of Stroke and Traumatic Brain Injury: The Role of Psychostimulants

1995 • 34 citations

The use of methylphenidate in depressed patients after cardiac surgery.

1984 • 34 citations

Comparison of sustained-release and standard methylphenidate in the treatment of minimal brain dysfunction.

1980 • 34 citations

Exogenous tyrosine potentiates the methylphenidate-induced increase in extracellular dopamine in the nucleus accumbens: a microdialysis study

1991 • 32 citations

Elderly depressed females as a possible subgroup of patients responsive to methylphenidate.

1986 • 32 citations

Medical Use of Psychostimulants: An Overview

1995 • 31 citations

Response of HIV-Related Depression to Psychostimulants: Case Reports

1988 • 31 citations

A CONTROLLED TRIAL OF METHYL PHENIDATE (RITALIN) IN THE TREATMENT OF DEPRESSIVE STATES

1958 • 29 citations

BEHAVIOR OF CHILDREN RECEIVING BENZEDRINE

1938 • 29 citations

Positron Emission Tomography Radioligands for Dopamine Transporters and Studies in Human and Nonhuman Primates

1997 • 29 citations

Attention-deficit/Hyperactivity Disorder

1997 • 28 citations

The Use of Methylphenidate for Cognitive Decline Associated with HIV Disease

1995 • 27 citations

Slow-release methylphenidate: problems when children chew tablets.

1984 • 27 citations

Methylphenidate as a treatment for depression in acquired immunodeficiency syndrome: an n-of-1 trial.

1992 • 27 citations

Depression in the Medically Ill Elderly: A Focus on Methylphenidate

1996 • 26 citations

Psychostimulant Drugs Potentiate Morphine Analgesia in the Formalin Test

1998 • 26 citations

SEPARATE AND COMBINED EFFECTS OF METHYLPHENIDATE AND A BEHAVIORAL INTERVENTION ON DISRUPTIVE BEHAVIOR IN CHILDREN WITH MENTAL RETARDATION

1996 • 23 citations

Methylphenidate in Post Liver Transplant Patients

1998 • 22 citations

DOUBLE-BLIND EVALUATION OF METHYLPHENIDATE (RITALIN) HYDROCHLORIDE

1959 • 22 citations

Methylphenidate for the management of somatization in terminal cancer patients

1995 • 21 citations

A Review of the Use of Augmentation Therapy for the Treatment of Resistant Depression: Implications for the Clinician

1997 • 20 citations

Long-term Methylphenidate Use in the Medically Ill Patient With Organic Mood Syndrome

1990 • 20 citations

Autoradiographic localization of [3H]methylphenidate binding sites in rat brain

1985 • 19 citations

Methylphenidate in the ‘hard to wean’ patient

1995 • 18 citations

Sustained-release methylphenidate for cognitive impairment in HIV-1- infected drug abusers: a pilot study

1997 • 18 citations

Differences in plasma concentrations of the d- and l-threo methylphenidate enantiomers in responding and non-responding children with attention-deficit hyperactivity disorder

1998 • 17 citations

Stereospecific distribution of methylphenidate enantiomers in rat brain: specific binding to dopamine reuptake sites.

1994 • 17 citations

Pharmacodynamic modeling for change of locomotor activity by methylphenidate in rats.

1997 • 16 citations

The Use of Methylphenidate in a Depressed Adolescent with AIDS

1990 • 15 citations

A STIMULANT FOR THE AGED. II. LONG‐TERM OBSERVATIONS WITH A METHYLPHENIDATE‐VITAMIN‐HORMONE COMBINATION (RITONIC)

1962 • 11 citations

A STIMULANT FOR THE AGED. OBSERVATIONS ON A METHYLPHENIDATE‐VITAMIN‐HORMONE COMBINATION (RITONIC)

1960 • 11 citations

Depressive states and drugs. III. Use of methylphenidate (Ritalin) in open psychiatric settings and in office practice.

1960 • 10 citations

Sustained Release Methylphenidate

2000 • 6 citations

Pharmacological factors of methylphenidate metabolism in behaviorally disordered children.

1980 • 2 citations