Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review
Data up to Jan 2025
Total Citations Per Year
Abstract
References (106)
Profile of mood states
1992 • 2,611 citations
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
1987 • 2,189 citations
Handbook of Experimental Pharmacology.
1971 • 1,547 citations
Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
1971 • 946 citations
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
1997 • 843 citations
Methods of Assessing the Reinforcing Properties of Abused Drugs
1987 • 684 citations
Is Methylphenidate Like Cocaine?
1995 • 575 citations
Increased Methylphenidate Usage for Attention Deficit Disorder in the 1990s
1996 • 419 citations
Association of Methylphenidate-Induced Craving With Changes in Right Striato-orbitofrontal Metabolism in Cocaine Abusers: Implications in Addiction
1999 • 410 citations
Prediction of Reinforcing Responses to Psychostimulants in Humans by Brain Dopamine D2 Receptor Levels
1999 • 406 citations
Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.
1999 • 403 citations
Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.
1989 • 389 citations
Effect of Stimulant Medication on Children with Attention Deficit Disorder: A “Review of Reviews”
1993 • 314 citations
FIXED‐INTERVAL SCHEDULE OF COCAINE REINFORCEMENT: EFFECT OF DOSE AND INFUSION DURATION1
1973 • 293 citations
The biological, social and clinical bases of drug addiction: commentary and debate
1996 • 277 citations
A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey.
1975 • 235 citations
Prediction of abuse liability of drugs using IV self-administration by rats
1983 • 234 citations
Psychomotor stimulant self administration as a function of dosage per injection in the Rhesus monkey
1971 • 195 citations
Replacement Medication for Cocaine Dependence
1997 • 194 citations
Drug preference and mood in humans: d-amphetamine
1980 • 190 citations
Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain
1999 • 185 citations
Relationship Between the Discriminative Stimulus Properties and Subjective Effects of Drugs
1988 • 177 citations
Methylphenidate Treatment for Cocaine Abusers With Adult Attention-Deficit/Hyperactivity Disorder
1998 • 168 citations
Release of dopamine via the human transporter.
1994 • 153 citations
Intravenous Self-Administration: Response Rates, the Effects of Pharmacological Challenges, and Drug Preference
1987 • 148 citations
The effects of haloperidol on amphetamine-and methylphenidate-induced conditioned place preferences and locomotor activity
1986 • 148 citations
Discriminative stimulus properties of cocaine: Neuropharmacological characteristics as derived from stimulus generalization experiments
1979 • 141 citations
Intravenous methylphenidate abuse. Prototype for prescription drug abuse.
1991 • 137 citations
Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans
1999 • 136 citations
Subjective and discriminative effects of drugs
1991 • 135 citations
Transduction Mechanisms of Drug Stimuli
1988 • 134 citations
Blockade of striatal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of "high".
1999 • 120 citations
Transduction Mechanisms of Drug Stimuli
1988 • 113 citations
Testing for abuse liability of drugs in humans
1989 • 108 citations
Reinforcing and Subject-Rated Effects of Methylphenidate and d-Amphetamine in Non–Drug-Abusing Humans
2001 • 107 citations
Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans.
1998 • 107 citations
Comparison of acute behavioral effects of sustained-release and immediate-release methylphenidate.
1998 • 103 citations
The role of dopamine in the discriminative stimulus properties of cocaine
1980 • 99 citations
Sustained Release Methylphenidate: Pharmacokinetic Studies in ADDH Males
1989 • 98 citations
Comparison of progressive-ratio performance maintained by cocaine, methylphenidate and secobarbital
1975 • 98 citations
Comparison of acute behavioral effects of sustained-release and immediate-release methylphenidate.
1998 • 95 citations
Discriminative stimulus properties of d-amphetamine and related compounds in rats
1974 • 94 citations
Comparative effects of d-amphetamine, l-amphetamine and methylphenidate on mood in man
1977 • 91 citations
Stimulant Use and the Potential for Abuse in Wisconsin as Reported by School Administrators and Longitudinally Followed Children
1998 • 90 citations
Intranasal abuse of prescribed methylphenidate by an alcohol and drug abusing adolescent with ADHD
1991 • 86 citations
Discriminative stimulus effects ofd-amphetamine, methylphenidate, and diazepam in humans
1991 • 83 citations
Behavioral pharmacological similarities between methylphenidate and cocaine in cocaine abusers.
2001 • 80 citations
A Fatality Due to the Intranasal Abuse of Methylphenidate (Ritalin®)
1999 • 78 citations
Discriminative stimulus properties of pentylenetetrazol and bemegride: Some generalization and antagonism tests
1979 • 76 citations
Applications and Limitations of the Drug Discrimination Method for the Study Of Drug Abuse
1987 • 76 citations
Binge cocaine self-administration in humans: intravenous cocaine
1997 • 75 citations
Acute psychologic and neuroendocrine effects of dextroamphetamine and methylphenidate
1978 • 74 citations
Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain
1999 • 74 citations
Stimulus properties of antidepressants in the rat
1980 • 74 citations
Self-administration in baboons and the discriminative stimulus effects in rats of bupropion, nomifensine, diclofensine and imipramine
1990 • 71 citations
Amphetamine-like effects of anorectics and related compounds in pigeons.
1987 • 69 citations
Human Abuse Liability Assessment by Measurement of Subjective and Physiological Effects
1989 • 69 citations
Reinforcing and subjective effects of methylphenidate in humans
1994 • 67 citations
Place preference conditioning with methylphenidate and nomifensine
1985 • 67 citations
Pharmacological characterization of the discriminative-stimulus effects of GBR 12909.
1991 • 64 citations
Temporal relationships between the pharmacokinetics of methylphenidate in the human brain and its behavioral and cardiovascular effects
1996 • 60 citations
Substitution and cross-tolerance profiles of anorectic drugs in rats trained to detect the discriminative stimulus properties of cocaine
1988 • 58 citations
Preclinical research on cocaine self-administration: environmental determinants and their interaction with pharmacological treatment
1999 • 58 citations
Factors influencing the reinforcing and subjective effects of ephedrine in humans
1994 • 56 citations
Fatality Resulting from Methylphenidate Overdose
1986 • 56 citations
The discriminative stimulus properties of 2,5-dimethoxy-4-methylamphetamine (DOM): Differentiation from amphetamine
1980 • 55 citations
Sleepiness and the reinforcing and subjective effects of methylphenidate.
1999 • 55 citations
A pharmacological analysis of the discriminative stimulus properties of d-amphetamine in rhesus monkeys.
1989 • 54 citations
Sleepiness and the reinforcing and subjective effects of methylphenidate.
1999 • 54 citations
Discriminative stimulus properties of intragastrically administered d-amphetamine and pentobarbital in rhesus monkeys.
1987 • 52 citations
A Comparison of Assessment Techniques Measuring the Effects of Methylphenidate, Secobarbital, Diazepam and Diphenhydramine in Abstinent Alcoholics
1988 • 51 citations
Use of Positron Emission Tomography to Study the Dynamics of Psychostimulant-Induced Dopamine Release
1997 • 48 citations
Self-administration of CNS stimulants by dog
1975 • 47 citations
Assessing Drugs for Abuse Liability and Dependence Potential in Laboratory Primates
1987 • 45 citations
Factors influencing the reinforcing and subjective effects of d-amphetamine in humans.
1993 • 41 citations
Psychologic and Neuroendocrine Response to Methylphenidate
1977 • 40 citations
Discriminative stimulus effects of S (−)-methcathinone (CAT): a potent stimulant drug of abuse
1998 • 40 citations
Factors influencing the reinforcing and subjective effects of d-amphetamine in humans
1993 • 39 citations
Differences in regional brain metabolic responses between single and repeated doses of methylphenidate
1998 • 39 citations
Methylphenidate: Increased Abuse or Appropriate Use ?
1999 • 38 citations
Discriminative properties of the psychostimulant dl-cathinone in a two lever operant task
1986 • 36 citations
Laboratory Measures of Methylphenidate Effects in Cocaine-Dependent Patients Receiving Treatment
2000 • 35 citations
Discriminative stimulus properties of a small dose of cocaine
1983 • 35 citations
Intravenous methylphenidate abuse. Prototype for prescription drug abuse
1991 • 34 citations
Discriminative Stimulus Properties of (−)Ephedrine
1998 • 34 citations
The specific activity of platelet monoamine oxidase varies with platelet count during severe exercise and noradrenaline infusion
1981 • 29 citations
Stimulus functions of drugs and the assessment of abuse liability
1990 • 28 citations
Methylphenidate (Ritalin) use and abuse.
1999 • 28 citations
Historical perspectives on the use of subjective effects measures in assessing the abuse potential of drugs.
1989 • 27 citations
Parkinsonian patients report blunted subjective effects of methylphenidate.
1998 • 26 citations
Emerging drugs of abuse in Connecticut.
2000 • 26 citations
Discriminative stimulus properties of amphetamine and other stimulants in lead-exposed and normal rats
1986 • 26 citations
Self-administration of central stimulants by rats: A comparison of the effects of d-amphetamine, methylphenidate and McNeil 4612
1984 • 24 citations
Characteristics of unlimited access to self-administered stimulant infusions in dogs.
1976 • 23 citations
Rapid substitution procedure for intravenous drug self-administration studies in rhesus monkeys
1979 • 23 citations
Discriminative and participant-rated effects of methylphenidate in children diagnosed with attention deficit hyperactivity disorder (ADHD).
1998 • 22 citations
A Drug Preference Procedure for use with Human Volunteers
1987 • 20 citations
ALCOHOL, TOBACCO AND OTHER DRUG USE BY INDIANA CHILDREN AND ADOLESCENTS
1999 • 18 citations
The Novel-Response Procedure in Humans
1999 • 16 citations
Methylphenidate (ritalin) abuse and methadone maintenance.
1975 • 15 citations
Pharmacological characterization of the discriminative stimulus properties of the phencyclidine analog, N -[1-(2-benzo(b)thiophenyl)-cyclohexyl]piperidine
1999 • 15 citations
Discriminative stimulus effects of a low dose of apomorphine in the rat
1987 • 14 citations
Effects of Methylphenidate Hydrochloride on the Subjective Reporting of Mood in Children with Attention Deficit Disorder
1988 • 12 citations
The effects of naloxone on methylphenidate-induced mood and behavioral changes: A negative study
1980 • 10 citations
The Study of Structure-Activity Relationships Using Drug Discrimination Methodology
1987 • 8 citations
Deleted Work
1955 • 0 citations