The degradation signal in a short-lived protein

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Methods in yeast genetics

1979 • 7,824 citations

Current protocols in molecular biology

1988 • 7,584 citations

Methods in Yeast Genetics

1988 • 4,905 citations

Proteins: Structures and Molecular Properties

1986 • 2,694 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

Intracellular protein topogenesis

1980 • 1,378 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

1987 • 731 citations

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

1980 • 727 citations

The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

1989 • 711 citations

Proteins: Structures and molecular properties

1985 • 697 citations

Tertiary Structure of Ribonuclease

1967 • 573 citations

Protein Import into the Cell Nucleus

1986 • 544 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

The gapped duplex DNA approach to oligonucleotide-directed mutation construction

1984 • 511 citations

Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane

1986 • 509 citations

Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells.

1984 • 502 citations

The yeast ubiquitin genes: a family of natural gene fusions.

1987 • 500 citations

Universality and Structure of the N-end Rule

1989 • 472 citations

INTRACELLULAR PROTEASES

1987 • 460 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

24 Bovine Pancreatic Ribonuclease

1971 • 437 citations

The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme

1988 • 435 citations

The heat shock response of E. coli is regulated by changes in the concentration of σ32

1987 • 414 citations

Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

1984 • 310 citations

The ubiquitin system: functions and mechanisms

1985 • 298 citations

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

1985 • 273 citations

Molecular determinants of protein half‐lives in eukaryotic cells

1987 • 268 citations

Identification of a primary in vivo degradation product of the rapidly-turning-over 32 kd protein of photosystem II.

1987 • 264 citations

A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences.

1984 • 251 citations

Effect of heat shock on protein degradation in mammalian cells: involvement of the ubiquitin system.

1987 • 235 citations

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis.

1982 • 234 citations

Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit β-globin

1980 • 227 citations

Red light-induced formation of ubiquitin-phytochrome conjugates: Identification of possible intermediates of phytochrome degradation

1987 • 224 citations

Arthrin, a myofibrillar protein of insect flight muscle, is an actin-ubiquitin conjugate

1987 • 210 citations

Protein degradation in E. coli: The ion mutation and bacteriophage lambda N and cll protein stability

1981 • 208 citations

Cotranslational processing and protein turnover in eukaryotic cells

1988 • 201 citations

Saccharomyces cerevisiae coordinates accumulation of yeast ribosomal proteins by modulating mRNA splicing, translational initiation, and protein turnover.

1985 • 194 citations

Signals guiding proteins to their correct locations in mitochondria

1987 • 145 citations

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.

1988 • 144 citations

Clustering of glycine and NG,NG-dimethylarginine in nucleolar protein C23

1985 • 134 citations

The resolution and characterization of putative ubiquitin carrier protein isozymes from rabbit reticulocytes.

1988 • 133 citations

Of urfs and orfs

1986 • 119 citations

Role of the SulB (FtsZ) protein in division inhibition during the SOS response in Escherichia coli: FtsZ stabilizes the inhibitor SulA in maxicells.

1985 • 113 citations

Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP.

1981 • 108 citations

Ribosomal protein synthesis is not regulated at the translational level in Saccharomyces cerevisiae: balanced accumulation of ribosomal proteins L16 and rp59 is mediated by turnover of excess protein.

1988 • 100 citations

hflB, a new Escherichia coli locus regulating lysogeny and the level of bacteriophage lambda cII protein

1986 • 98 citations

The accumulation of three yeast ribosomal proteins under conditions of excess mRNA is determined primarily by fast protein decay.

1988 • 90 citations

Induction of the heat shock response of E. coli through stabilization of sigma 32 by the phage lambda cIII protein.

1987 • 76 citations

The lacI Gene: Its Role in lac Operon Control and Its Use as a Genetic System

1980 • 74 citations

The biological clock in Gonyaulax controls luciferase activity by regulating turnover.

1981 • 73 citations

Specific recognition of calmodulin from Dictyostelium discoideum by the ATP, ubiquitin-dependent degradative pathway.

1985 • 71 citations

Rapid intracellular turnover of adenovirus 5 early region 1A proteins

1984 • 62 citations

Tobacco mosaic virus particles contain ubiquitinated coat protein subunits

1988 • 58 citations

[11]Complementation in folding and fragment exchange

1986 • 57 citations

[21]Protein conformational dynamics measured by hydrogen isotope exchange techniques

1986 • 51 citations

Ribonuclease structure and catalysis: crystal structure of sulfate-free native ribonuclease A at 1.5- .ANG. resolution

1987 • 50 citations

[22] Methotrexate-agarose in the purification of dihydrofolate reductase

1974 • 50 citations

Ubiquitin carrier protein-catalyzed ubiquitin transfer to histones. Mechanism and specificity.

1988 • 49 citations

Regulation of Gene Expression

1994 • 27 citations

Degradation of proteins microinjected into HeLa cells. The role of substrate flexibility.

1986 • 23 citations

Ubiquitinated Histones and Chromatin

1988 • 22 citations

The use of limited proteolysis to probe interdomain and active site regions of beta-galactosidase (Escherichia coli).

1988 • 21 citations

A class of Escherichia coli proteins controlled by the hflA locus

1987 • 20 citations

Molecular Genetics of the Ubiquitin System

1988 • 17 citations

Degradation of the precursor of mitochondrial aspartate aminotransferase in chicken embryo fibroblasts.

1988 • 10 citations

Lymphocyte Homing Receptors, Ubiquitin, and Cell Surface Proteins

1988 • 8 citations

Deleted Work

1955 • 0 citations