Loss of locus coeruleus neurons and reduced startle in parkin null mice

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Staging of brain pathology related to sporadic Parkinson’s disease

2002 • 9,557 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

mouse brain in stereotaxic coordinates

1997 • 3,077 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

2003 • 2,691 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

Parkinson's Disease

1998 • 1,953 citations

Molecular Pathways of Neurodegeneration in Parkinson's Disease

2003 • 1,634 citations

Association between Early-Onset Parkinson's Disease and Mutations in theParkinGene

2000 • 1,398 citations

Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems

1979 • 1,361 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

2001 • 1,048 citations

Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

2001 • 1,036 citations

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

2000 • 975 citations

New stereological methods for counting neurons

1993 • 951 citations

Neuronal Loss Is Greater in the Locus Coeruleus Than Nucleus Basalis and Substantia Nigra in Alzheimer and Parkinson Diseases

2003 • 945 citations

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

2003 • 884 citations

Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

2001 • 738 citations

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

2003 • 500 citations

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

1997 • 438 citations

Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

1994 • 394 citations

Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity

2003 • 385 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein

1998 • 302 citations

Surprisingly rich projection from locus coeruleus to the olfactory bulb in the rat

1985 • 287 citations

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.

2003 • 282 citations

Noradrenaline neuron innervation of the neocortex in the rat

1978 • 265 citations

Parkin Binds to α/β Tubulin and Increases their Ubiquitination and Degradation

2003 • 247 citations

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration

2003 • 239 citations

Are Ubiquitination Pathways Central to Parkinson's Disease?

2003 • 232 citations

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

2003 • 217 citations

Complex relationship between Parkin mutations and Parkinson disease

2002 • 209 citations

An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in theparkin gene

2000 • 209 citations

Deletion of Exon 6 of the Neuronal Nitric Oxide Synthase Gene in Mice Results in Hypogonadism and Infertility

2002 • 151 citations

Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age

2003 • 148 citations

Role of dopamine in prepulse inhibition of acoustic startle

2000 • 126 citations

Genetics of Parkinson's disease

2001 • 124 citations

Genetics of Parkinson's disease.

2004 • 108 citations

Autosomal recessive parkinsonism linked to parkin gene in a Tunisian family. Clinical, genetic and pathological study

2003 • 87 citations

Efferent projections of different subpopulations of central noradrenaline neurons

1991 • 80 citations

Autosomal recessive early-onset parkinsonism with diurnal fluctuation: clinicopathologic characteristics and molecular genetic identification

2000 • 75 citations

Molecular cloning, gene expression, and identification of a splicing variant of the mouse parkin gene

2000 • 66 citations

Effects of 6-hydroxydopamine lesions of locus coeruleus on startle in rats

1981 • 65 citations

Norepinephrine effects on spinal motoneurons

1991 • 64 citations

Differential expression of the parkin gene in the human brain and peripheral leukocytes

1998 • 53 citations

Spinal modulation of the acoustic startle response: the role of norepinephrine, serotonin and dopamine

1981 • 53 citations

Central noradrenergic involvement in yohimbine excitation of acoustic startle: Effects of DSP4 and 6-OHDA

1985 • 43 citations

Identification and characterization of the human parkin gene promoter

2001 • 38 citations

The genetics of Parkinson’s disease

2002 • 34 citations