Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Molecular cloning of a potential proteinase activated receptor.

1994 • 887 citations

Protease-activated receptor 3 is a second thrombin receptor in humans

1997 • 878 citations

Cloning and characterization of human protease-activated receptor 4

1998 • 807 citations

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

2000 • 799 citations

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases

1998 • 785 citations

Matrix metalloproteinases: multifunctional contributors to tumor progression

2000 • 639 citations

Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2

1997 • 592 citations

Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion

1999 • 583 citations

Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate.

1984 • 532 citations

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

1996 • 457 citations

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

1997 • 427 citations

Molecular Cloning and Functional Expression of the Gene Encoding the Human Proteinase‐Activated Receptor 2

1995 • 334 citations

Characterization of Protease-activated Receptor-2 Immunoreactivity in Normal Human Tissues

1998 • 325 citations

Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2

1997 • 319 citations

Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2

2000 • 300 citations

The Bowman-Birk inhibitor from soybeans as an anticarcinogenic agent

1998 • 292 citations

Mechanisms of Desensitization and Resensitization of Proteinase-activated Receptor-2

1996 • 246 citations

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

1997 • 240 citations

Protease activated receptors: theme and variations

2001 • 220 citations

Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2

1997 • 217 citations

Ligand Cross-reactivity within the Protease-activated Receptor Family

1996 • 210 citations

Expression of Trypsin by Epithelial Cells of Various Tissues, Leukocytes, and Neurons in Human and Mouse

1998 • 208 citations

Rat proteinase‐activated receptor‐2 (PAR‐2): cDNA sequence and activity of receptor‐derived peptides in gastric and vascular tissue

1996 • 200 citations

Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2

1999 • 182 citations

Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation.

1992 • 171 citations

Endothelial Cell Thrombin Receptors and PAR-2

1997 • 165 citations

Effect of proteases on activation of resting chick embryo fibroblasts and on cell surface proteins

1975 • 154 citations

Proteinase-activated receptor 2 (PAR ₂ )-activating peptides: Identification of a receptor distinct from PAR ₂ that regulates intestinal transport

1998 • 153 citations

Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: An immunohistochemical study

1997 • 139 citations

Review article: proteinase‐activated receptors — novel signals for gastrointestinal pathophysiology

2000 • 134 citations

Multiple secretion of matrix serine proteinases by human gastric carcinoma cell lines.

1992 • 131 citations

Insulinlike growth factors and binding proteins in colon cancer

1993 • 126 citations

Mitogenic Responses Mediated Through the Proteinase-Activated Receptor-2 Are Induced by Expressed Forms of Mast Cell α- or β-Tryptases

1997 • 120 citations

Trypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases

1996 • 107 citations

Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice

1999 • 105 citations

Importance of bile in regulation of intraluminal proteolytic enzyme activities in the rat

1980 • 101 citations

Expression of trypsin in vascular endothelial cells

1997 • 99 citations

Initiation of chick cell division by trypsin action at the cell surface

1977 • 85 citations

Prevention of carcinogenesis by protease inhibitors.

1994 • 81 citations

Protease-mediated signalling: new paradigms for cell regulation and drug development

1996 • 79 citations

Expression of Trypsin in Human Cancer Cell Lines and Cancer Tissues and Its Tight Binding to Soluble Form of Alzheimer Amyloid Precursor Protein in Culture

1999 • 79 citations

Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM

2000 • 73 citations

Trypsinogen expression in human ovarian carcinomas

1995 • 71 citations

Development of vasoactive intestinal peptide-responsive adenylate cyclase during enterocytic differentiation of Caco-2 cells in culture. Evidence for an increased receptor level.

1987 • 64 citations

Differential Expression of Functional Protease-Activated Receptor-2 (PAR-2) in Human Vascular Smooth Muscle Cells

1998 • 60 citations

Evidence for the activation of PAR‐2 by the sperm protease, acrosin: expression of the receptor on oocytes

2000 • 54 citations

Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human gastric cancer cells

1998 • 53 citations

Serum trypsinogen-2 and trypsin-2-α1-antitrypsin complex in malignant and benign digestive-tract diseases. Preferential elevation in patients with cholangiocarcinomas

1996 • 52 citations

Protein-tyrosine Phosphatase SHP2 Is Positively Linked to Proteinase-activated Receptor 2-mediated Mitogenic Pathway

1997 • 48 citations

The immunohistochemical demonstration of chymase and tryptase in human intestinal mast cells

1994 • 38 citations

Epidermal growth factor-related peptides as targets for experimental therapy of human colon carcinoma.

1998 • 31 citations

Marked increase of trypsin(ogen) in serum of linitis plastica (gastric cancer, borrmann 4) patients.

2000 • 25 citations

Proteases and cancer invasion: from belief to certainty

1999 • 20 citations

Pancreatic trypsinogen I expression during cell growth and differentiation of two human colon carcinoma cells

1998 • 15 citations

Colonic proteolysis following pancreatic duct ligation in the rat

1994 • 6 citations