Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Aberrant Crypt Foci of the Colon as Precursors of Adenoma and Cancer

1998 • 591 citations

Molecular determinants of dysplasia in colorectal lesions.

1994 • 506 citations

Aberrant crypts: putative preneoplastic foci in human colonic mucosa.

1991 • 448 citations

Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects.

1988 • 380 citations

Growth-Promoting Effects of Glycine-Extended Progastrin

1994 • 336 citations

Identification and quantification of aberrant crypt foci and microadenomas in the human colon

1991 • 316 citations

Aberrant crypts: potential preneoplastic lesions in the murine colon.

1988 • 305 citations

Processing and proliferative effects of human progastrin in transgenic mice.

1996 • 298 citations

Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons.

1994 • 286 citations

Gastrin and colorectal cancer: A prospective study

1998 • 267 citations

Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-deficient mice

1997 • 202 citations

Expression, processing, and secretion of gastrin in patients with colorectal carcinoma

1995 • 186 citations

I. CCK receptors: an exemplary family

1998 • 177 citations

Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line

1997 • 133 citations

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

1995 • 130 citations

Novel Gastrin Receptors Mediate Mitogenic Effects of Gastrin and Processing Intermediates of Gastrin on Swiss 3T3 Fibroblasts

1995 • 117 citations

Identification of progastrin derived peptides in colorectal carcinoma extracts.

1993 • 116 citations

Nutritional factors and colon cancer

1995 • 109 citations

Elevated gastrin levels in patients with colon cancer or adenomatous polyps

1989 • 107 citations

Chronic endogenous hypergastrinemia in humans: Evidence for a mitogenic effect on the colonic mucosa

1993 • 100 citations

Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells.

1996 • 98 citations

Specificity study to evaluate induction of aberrant crypts in murine colons.

1988 • 97 citations

Inhibition of aberrant crypt growth by non‐steroidal anti‐inflammatory agents and differentiation agents in the rat colon

1995 • 92 citations

Regulation of growth of human gastric cancer by gastrin and glycine- extended progastrin

1997 • 91 citations

Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines

1998 • 89 citations

Gastrointestinal hormones and gastrointestinal and pancreatic carcinomas

1986 • 82 citations

Gastrin, gastrin receptors and colorectal carcinoma

1998 • 77 citations

AOM-induced mouse colon tumors do not express full-length APC protein

1997 • 72 citations

Oncogenic ras induces gastrin gene expression in colon cancer

1998 • 72 citations

Elevated Serum Gastrin Levels in Patients with Colorectal Neoplasia

1991 • 60 citations

Plasma gastrin concentrations are normal in patients with colorectal neoplasia and unaltered following tumor resection

1994 • 60 citations

Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas

1995 • 53 citations

Prolonged hypergastrinemia does not increase the frequency of colonic neoplasia in patients with Zollinger-Ellison syndrome

1996 • 52 citations

Incomplete processing of progastrin expressed by human colon cancer cells: role of noncarboxyamidated gastrins

1994 • 52 citations

Transfected cholecystokinin receptors mediate growth inhibitory effects on human pancreatic cancer cell lines

1997 • 49 citations

Drug-induced hypergastrinemia: Absence of trophic effects on colonic carcinoma in rats

1995 • 40 citations

Growth factor balance and tumor progression

1994 • 32 citations

Cytotoxic agents directed to peptide hormone receptors: Defining the requirements for a successful drug

1998 • 29 citations

Different genetic susceptibility to aberrant crypts and colon adenomas in mice.

1996 • 25 citations

Genetics of colorectal cancer

1998 • 21 citations

Inhibition of aberrant crypt foci by chemopreventive agents.

1998 • 18 citations

Circadian rhythms in gastrin receptors in rat fundic stomach

1988 • 17 citations

Differential activation of IGF-II promoters P3 and P4 in Caco-2 cells during growth and differentiation

1998 • 15 citations

Gut hormones in colon cancer: Past and prospective studies

1990 • 12 citations

Serum gastrin levels in patients with colorectal cancer and adenomatous polyps: a prospective study.

1995 • 11 citations

Transient transcriptional activation of gastrin during sodium butyrate-induced differentiation of islet cells

1997 • 7 citations

Gastrin levels in colorectal cancer.

1997 • 7 citations