DNA Methylation and Development

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

1999 • 5,748 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Epigenetic Reprogramming in Mammalian Development

2001 • 2,978 citations

Perceptions of epigenetics

2007 • 2,788 citations

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

2011 • 2,558 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

Completion of mouse embryogenesis requires both the maternal and paternal genomes

1984 • 1,529 citations

Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis

1984 • 1,402 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

2011 • 1,199 citations

The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

2007 • 1,188 citations

Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation

2005 • 1,160 citations

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1979 • 1,101 citations

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

2011 • 1,096 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

1987 • 1,088 citations

Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

2005 • 1,077 citations

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

2011 • 1,060 citations

Dnmt3a is essential for hematopoietic stem cell differentiation

2011 • 998 citations

REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis

2005 • 900 citations

Genomic imprinting: the emergence of an epigenetic paradigm

2011 • 791 citations

Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse

1975 • 783 citations

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

2011 • 749 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

Differential activity of maternally and paternally derived chromosome regions in mice

1985 • 708 citations

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

2011 • 656 citations

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

1989 • 655 citations

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells

2011 • 621 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b

2006 • 543 citations

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

2011 • 484 citations

Genomic imprinting determines methylation of parental alleles in transgenic mice

1987 • 480 citations

Parental legacy determines methylation and expression of an autosomal transgene: A molecular mechanism for parental imprinting

1987 • 478 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

Genomic Sequencing and Methylation Analysis by Ligation Mediated PCR

1989 • 408 citations

Degree of methylation of transgenes is dependent on gamete of origin

1987 • 407 citations

DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling

2005 • 406 citations

Epigenetic reprogramming during early development in mammals

2004 • 394 citations

Transfection of a DNA locus that mediates the conversion of 10T12 fibroblasts to myoblasts

1986 • 376 citations

DNA methylation and imprinting: why bother?

1997 • 370 citations

The somatic replication of DNA methylation

1981 • 368 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors

1987 • 356 citations

Regulation of X-chromosome inactivation by the X-inactivation centre

2011 • 347 citations

5-azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: Evidence for regulatory genes controlling determination

1984 • 330 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse.

1987 • 278 citations

Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma

1989 • 221 citations

REVIEW ARTICLE: Epigenetics in the Placenta

2009 • 193 citations

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

2012 • 186 citations

ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta

2010 • 172 citations

Anticipation in Huntington's disease is inherited through the male line but may originate in the female.

1988 • 171 citations

Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase.

1986 • 164 citations

Inviability of parthenogenones is determined by pronuclei, not egg cytoplasm

1984 • 148 citations

Muscle-specific activation of a methylated chimeric actin gene

1986 • 135 citations

Reversal of X-inactivation in female mouse somatic cells hybridized with murine teratocarcinoma stem cells in vitro

1983 • 127 citations

Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA.

1988 • 119 citations

Stem cells and lineage development in the mammalian blastocyst

2006 • 113 citations

Derepression of genes on the human inactive X chromosome: Evidence for differences in locus-specific rates of derepression and rates of transfer of active and inactive genes after DNA-mediated transformation

1982 • 110 citations

From Zygote to Implantation: Morphological and Molecular Dynamics during Embryo Development in the Pig

2009 • 110 citations

DNA Methylation Is Dispensable for the Growth and Survival of the Extraembryonic Lineages

2010 • 109 citations

An estrogen-dependent demethylation at the 5′ end of the chicken vitellogenin gene is independent of DNA synthesis

1984 • 106 citations

Methylation of the mouse hprt gene differs on the active and inactive X chromosomes.

1986 • 105 citations

The Liberation of Embryonic Stem Cells

2011 • 101 citations

Genetic and epigenetic control of early mouse development

2009 • 96 citations

The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated.

1988 • 96 citations

Complete concordance between glucose-6-phosphate dehydrogenase activity and hypomethylation of 3′ CpG clusters: implications for X chromosome dosage compensation

1984 • 92 citations

High-frequency conversion to a "fluffy" developmental phenotype in Aspergillus spp. by 5-azacytidine treatment: evidence for involvement of a single nuclear gene.

1983 • 90 citations

Stage-by-Stage Change in DNA Methylation Status of Dnmt1 Locus during Mouse Early Development

2005 • 88 citations

Studies on gene control regions XII. The functional significance of a Lac operator constitutive mutation

1979 • 84 citations

Cytosine methylation in CTF and Spl recognition sites of an HSV tk promoter: effects on transcriptionin vivoand on factor bindingin vitro

1989 • 79 citations

The maintenance of methylation-free islands in transgenic mice.

1986 • 70 citations

Genomic imprinting: a possible mechanism for the parental origin effect in Huntington's chorea.

1988 • 67 citations

Effects of Antenatal Synthetic Glucocorticoid on Glucocorticoid Receptor Binding, DNA Methylation, and Genome-Wide mRNA Levels in the Fetal Male Hippocampus

2013 • 65 citations

Reactivation of the methylation-inactivated late E2A promoter of adenovirus type 2 by E1A (13 S) functions

1988 • 64 citations

DNA methylation pattern in pig in vivo produced embryos

2006 • 61 citations

Long term effects of pre- and early postnatal nutrition and environment on the gut1

2012 • 54 citations

Tissue-specific methylation patterns and expression of the human apolipoprotein AI gene.

1990 • 54 citations

Epigenetic regulation of hematopoiesis

2012 • 47 citations

DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination

2010 • 45 citations

Establishment of epigenetic patterns in development

2012 • 43 citations

Coreactivation of four inactive X genes in a hamster � human hybrid and persistence of late replication of reactivated X chromosome

1983 • 43 citations

X chromosome reactivation in mouse embryonal carcinoma cells.

1985 • 42 citations

DNA Methylation Restricts Lineage-specific Functions of Transcription Factor Gata4 during Embryonic Stem Cell Differentiation

2013 • 40 citations

Effect of DNA Methylation on Gene Expression

1983 • 39 citations

Demethylation of genes in animal cells

1990 • 32 citations

X-chromosome activity in heterokaryons and hybrids between mouse fibroblasts and teratocarcinoma stem cells

1982 • 32 citations

Establishment of Bovine Trophoblast Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos Using Two Inhibitors

2014 • 31 citations

5-aza-C-induced changes in the time of replication of the X chromosomes of Microtus agrestis are followed by non-random reversion to a late pattern of replication

1987 • 19 citations

Epigenetic Reprogramming of Mesenchymal Stem Cells

2012 • 18 citations

Expression of Cholecystokinin Type A Receptor Gene Correlates with DNA Demethylation during Postnatal Development of Rat Pancreas

1999 • 12 citations