Cell-type specific and differential regulation of the human metallothionein genes. Correlation with DNA methylation and chromatin structure.

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

1985 • 1,042 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

1988 • 587 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences

1985 • 498 citations

DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells

1981 • 464 citations

Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene

1982 • 464 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences

1985 • 353 citations

DNA methylation, biochemistry, and biological significance

1984 • 343 citations

Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids

1984 • 331 citations

DNA methylation patterns Formation and function

1984 • 312 citations

Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids

1981 • 284 citations

Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.

1987 • 218 citations

Interleukin 1 regulates human metallothionein gene expression.

1985 • 185 citations

Duplicated heavy metal control sequences of the mouse metallothionein-I gene.

1984 • 167 citations

Advances in hepatitis research

1985 • 160 citations

Ultraviolet radiation-induced metallothionein-I gene activation is associated with extensive DNA demethylation

1983 • 159 citations

Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

1984 • 153 citations

Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer

1986 • 146 citations

Structure of mammalian metallothionein.

1984 • 129 citations

Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element.

1985 • 122 citations

Cell specificity and an effect of ras on human metallothionein gene expression.

1986 • 114 citations

In Vivo Competition Between a Metallothionein Regulatory Element and the SV40 Enhancer

1986 • 106 citations

5-azacytidine permits gene activation in a previously noninducible cell type

1985 • 105 citations

An improved method for the rapid isolation of brain ribonucleic acid

1979 • 101 citations

Methylation, expression and chromosomal position of genes in mammals

1984 • 100 citations

Regulation of human metallothionein (MT) genes. Differential expression of MTI-F, MTI-G, and MTII-A genes in the hepatoblastoma cell line (HepG2).

1988 • 99 citations

Structure and tissue-specific expression of the human metallothionein IB gene.

1986 • 89 citations

Structure and expression of two human metallothionein-I isoform genes and a related pseudogene.

1985 • 86 citations

Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids.

1986 • 76 citations

Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids

1981 • 67 citations

Induction of Metallothionein mRNA in HeLa Cells by Dexamethasone and by Heavy Metals

1981 • 64 citations

Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals.

1988 • 58 citations

Metallothionein gene expression in fish cell lines: Its activation in embryonic cells by 5-azacytidine

1987 • 50 citations

Identification of a cadmium-binding protein from a cadmium-resistant variant of human lymphoblastoid cells (WI-L2)

1983 • 8 citations

Human metallothionein-specific riboprobes

1987 • 5 citations

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