Caspases (Interleukin-1β-Converting Enzyme Family Proteases) Are Involved in the Regulation of the Survival of Osteoclasts

Apoptosis by Death Factor

1997 • 5,038 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

1995 • 1,039 citations

Modulation of Osteoclast Differentiation

1992 • 1,014 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Apoptosis

1993 • 972 citations

Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β

1996 • 799 citations

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1995 • 600 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Resorption of bone by isolated rabbit osteoclasts

1984 • 423 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts.

1993 • 360 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

1994 • 320 citations

Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice

1997 • 292 citations

Isolated osteoclasts resorb the organic and inorganic components of bone.

1986 • 276 citations

Bcl-2 expression prevents activation of the ICE protease cascade.

1996 • 254 citations

Identification of osteopontin in isolated rabbit osteoclasts

1992 • 213 citations

Programmed cell death and the control of cell survival

1994 • 169 citations

Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cells.

1995 • 167 citations

Preparation and characterization of a mouse osteoclast-like multinucleated cell population

1992 • 159 citations

The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

Wortmannin, a specific inhibitor of phosphatidylinositol‐3 kinase, blocks osteoclastic bone resorption

1995 • 148 citations

Vitamin K2Inhibits Osteoclastic Bone Resorption by Inducing Osteoclast Apoptosis

1996 • 138 citations

Ceramide induces apoptosis via CPP32 activation

1996 • 133 citations

Autocrine signals enable chondrocytes to survive in culture.

1994 • 133 citations

Interleukin-1α Activates an NF-κB-like Factor in Osteoclast-like Cells

1996 • 88 citations

Analysis of the Role of bcl‐2 in Apoptosis

1994 • 79 citations

In vitro and in vivo studies of ICE inhibitors

1997 • 72 citations

Specific Inhibitors of Vacuolar H+-ATPase Trigger Apoptotic Cell Death of Osteoclasts

1997 • 70 citations

Detection and Characterization of Apoptosis in Osteoclasts in Vitro

1995 • 63 citations

Calcitonin promotes osteoclast survival in vitro

1996 • 62 citations

Activin A‐induced apoptosis is suppressed by BCL‐2

1995 • 32 citations

EI-1511-3, -5 and EI-1625-2, Novel Interleukin-1.BETA. Converting Enzyme Inhibitors Produced by Streptomyces sp. E-1511 and E-1625. III. Biochemical Properties of EI-1511-3, -5 and EI 1625-2.

1996 • 29 citations

EI-1511-3, -5 and EI-1625-2, Novel Interleukin-1.BETA. Converting Enzyme Inhibitors Produced by Streptomyces sp. E-1511 and E-1625. I. Taxonomy of Producing Strain, Fermentation and Isolation.

1996 • 14 citations

Mechanism of osteoclast-mediated bone resorption

1996 • 13 citations

Regulatory mechanisms of osteoclast differentiation and function

1996 • 6 citations