Glucocorticoids and rheumatoid arthritis: Back to the future?

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Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

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Radiographic Evaluation of Rheumatoid Arthritis and Related Conditions by Standard Reference Films

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A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis

2000 • 1,757 citations

The mortality of rheumatoid arthritis

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Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs

1991 • 1,260 citations

Alendronate for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis

1998 • 1,256 citations

INFLIXIMAB AND METHOTREXATE IN THE TREATMENT OF RHEUMATOID ARTHRITIS

2000 • 1,181 citations

Glucocorticoid-Induced Osteoporosis: Pathogenesis and Management

1990 • 1,088 citations

Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis

1997 • 1,087 citations

Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

1979 • 928 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

Recommendations for the prevention and treatment of glucocorticoid‐induced osteoporosis

1996 • 852 citations

The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis

1995 • 804 citations

The Effect of a Hormone of the Adrenal Cortex (17-hydroxy-11-dehydrocorticosterone: Compound E) and of Pituitary Adrenocorticotropic Hormone on Rheumatoid Arthritis

1949 • 781 citations

Glucocorticoid Therapy for Immune-Mediated Diseases: Basic and Clinical Correlates

1993 • 762 citations

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Intermittent Etidronate Therapy to Prevent Corticosteroid-Induced Osteoporosis

1997 • 688 citations

Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: Results from 394 patients in the Oslo County rheumatoid arthritis register

2000 • 672 citations

Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis: 2001 update

2001 • 649 citations

Generalised bone loss in patients with early rheumatoid arthritis

1994 • 628 citations

Risedronate therapy prevents corticosteroid-induced bone loss : A twelve-month, multicenter, randomized, double-blind, placebo-controlled, parallel-group study

1999 • 625 citations

COBRA combination therapy in patients with early rheumatoid arthritis: Long‐term structural benefits of a brief intervention

2002 • 615 citations

The Effect of In Vivo Hydrocortisone on Subpopulations of Human Lymphocytes

1974 • 607 citations

Corticosteroid Use and Peptic Ulcer Disease: Role of Nonsteroidal Anti-inflammatory Drugs

1991 • 606 citations

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1979 • 567 citations

Prenatal Exposure to Prednisone in Humans and Animals Retards Intrauterine Growth

1978 • 540 citations

Prevention of Corticosteroid Osteoporosis -- A Comparison of Calcium, Calcitriol, and Calcitonin

1993 • 533 citations

Low dose long-term corticosteroid therapy in rheumatoid arthritis: An analysis of serious adverse events

1994 • 532 citations

Low-Dose Prednisone Therapy for Patients with Early Active Rheumatoid Arthritis: Clinical Efficacy, Disease-Modifying Properties, and Side Effects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2002 • 481 citations

Association of Adrenocorticosteroid Therapy and Peptic-Ulcer Disease

1983 • 429 citations

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1999 • 413 citations

Low-Dose Prednisone Induces Rapid Reversible Axial Bone Loss in Patients with Rheumatoid Arthritis

1993 • 404 citations

Antifracture Efficacy of Antiresorptive Agents Are Related to Changes in Bone Density

2000 • 404 citations

New Developments in the Pathogenesis and Treatment of Steroid-Induced Osteoporosis

1999 • 390 citations

Transcriptional cross-talk, the second mode of steroid hormone receptor action

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Reduction of Serum Testosterone Levels During Chronic Glucocorticoid Therapy

1986 • 385 citations

Risk of vertebral fracture and relationship to bone mineral density in steroid treated rheumatoid arthritis.

1995 • 381 citations

Bone loss in response to long-term glucocorticoid therapy

1990 • 378 citations

INTERMITTENT ETIDRONATE THERAPY TO PREVENT CORTICOSTEROID- INDUCED OSTEOPOROSIS

1997 • 369 citations

Glucocorticoid-Induced Inhibition of T Cell Growth Factor Production

1979 • 364 citations

Rheumatoid arthritis, corticosteroid therapy and hip fracture.

1995 • 362 citations

Inhaled and Nasal Glucocorticoids and the Risks of Ocular Hypertension or Open-angle Glaucoma

1997 • 352 citations

Regulation of cytokine and cytokine receptor expression by glucocorticoids

1996 • 326 citations

Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids

2002 • 325 citations

Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms.

1988 • 317 citations

Calcium and Vitamin D₃Supplementation Prevents Bone Loss in the Spine Secondary to Low-Dose Corticosteroids in Patients with Rheumatoid Arthritis

1996 • 310 citations

Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids

2002 • 306 citations

Steroid myopathy in connective tissue disease

1976 • 293 citations

Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis

1999 • 287 citations

Evaluation of factors associated with glucocorticoid‐induced osteopenia in patients with rheumatic diseases

1985 • 285 citations

Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: Results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis

2000 • 282 citations

On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion.

1990 • 279 citations

Effects of Corticosteroid Therapy on Human Monocyte Function

1975 • 268 citations

Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions.

1978 • 267 citations

Remodeling the pyramid--a concept whose time has come.

1989 • 246 citations

Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study.

1991 • 242 citations

Risk of vertebral fracture in women with rheumatoid arthritis.

1993 • 233 citations

Vertebral and peripheral bone mineral content and fracture incidence in postmenopausal patients with rheumatoid arthritis: effect of low dose corticosteroids.

1986 • 218 citations

Corticosteroids and Glaucoma Risk

1999 • 212 citations

Joint destruction after glucocorticoids are withdrawn in early rheumatoid arthritis. Arthritis and Rheumatism Council Low Dose Glucocorticoid Study Group

1998 • 207 citations

The effect on memory of chronic prednisone treatment in patients with systemic disease

1996 • 206 citations

Inhibition by glucocorticoids of the formation of interleukin-1 alpha, interleukin-1 beta, and interleukin-6: mediation by decreased mRNA stability.

1993 • 202 citations

An assessment of the effects of glucocorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils.

1989 • 202 citations

Bone loss in adults receiving alternate day glucocorticoid therapy

1981 • 198 citations

Signal transduction and transcription factors in rheumatic disease

1999 • 197 citations

The effect of rheumatoid arthritis and steroid therapy on bone density in postmenopausal women

1993 • 193 citations

Osteoporosis in rheumatoid arthritis: safety of low dose corticosteroids.

1986 • 189 citations

Anti-inflammatory lipocortin 1 production by peripheral blood leucocytes in response to hydrocortisone

1990 • 186 citations

Determinants of Vertebral Mineral Density in Patients Receiving Long-term Glucocorticoid Therapy

1990 • 183 citations

The relative toxicity of disease‐modifying antirheumatic drugs

1993 • 183 citations

Pituitary adrenal recovery following short-term suppression with corticosteroids

1979 • 178 citations

Osteoclastic activation is the principal mechanism leading to secondary osteoporosis in rheumatoid arthritis.

1998 • 177 citations

Glucocorticoid effects on the production and actions of immune cytokines

1988 • 176 citations

On the various forms of corticosteroid withdrawal syndrome

1980 • 173 citations

Recovery of the hypothalamic-pituitary-adrenal (HPA) axis in patients with rheumatic diseases receiving low-dose prednisone

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ZWEI RONTGENOLOGISCH DIAGNOSTIZIERTE FALLE VON MILZARTERIENANEURYSMA

1937 • 161 citations

Mortality in rheumatoid arthritis: have we made an impact in 4 decades?

1999 • 160 citations

MAJOR UNDESIRABLE SIDE-EFFECTS RESULTING FROM PREDNISOLONE AND PREDNISONE

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Novel mechanism for inhibition of human T cells by glucocorticoids. Glucocorticoids inhibit signal transduction through IL-2 receptor.

1993 • 151 citations

Predictors of fractures in early rheumatoid arthritis.

1991 • 150 citations

Mechanisms of corticosteroid action on lymphocyte subpopulations. II. Differential effects of in vivo hydrocortisone, prednisone and dexamethasone on in vitro expression of lymphocyte function.

1976 • 149 citations

Effects of low dose corticosteroids on bone mass in rheumatoid arthritis: a longitudinal study.

1989 • 146 citations

Steroid myopathy. Clinical, histologic and cytologic observations.

1968 • 143 citations

Effect of Corticosteroids on Cataract Formation

1980 • 142 citations

The effect of a hormone of the adrenal cortex ( 17-hydroxy-11-dehydrocortisone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis: preliminary report

1949 • 137 citations

Effects of glucocorticoids on carbohydrate metabolism

1976 • 132 citations

Low dose prednisone therapy in rheumatoid arthritis: a double blind study.

1983 • 129 citations

Decreased axial bone mineral density in perimenopausal women with rheumatoid arthritis--a population based study.

1994 • 129 citations

Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells

1995 • 128 citations

A Comparison of Prednisolone with Aspirin or other Analgesics in the Treatment of Rheumatoid Arthritis: M. R. C. Report

1959 • 116 citations

Rheumatoid arthritis and bone mineral density in elderly women

1995 • 114 citations

Effects of pulse methylprednisolone on inflammatory mediators in peripheral blood, synovial fluid, and synovial membrane in rheumatoid arthritis

1997 • 113 citations

Alternate-day corticosteroid therapy

1978 • 111 citations

Meta-analysis of short term low dose prednisolone versus placebo and non-steroidal anti-inflammatory drugs in rheumatoid arthritis

1998 • 110 citations

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1972 • 109 citations

Problems of an Ageing Population

1960 • 108 citations

Bone loss after glucocorticoid therapy

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The systemic effect of intraarticular administration of corticosteroid on markers of bone formation and bone resorption in patients with rheumatoid arthritis

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Psychiatric Side Effects of Steroid Therapy

1989 • 103 citations

The Association of Cataract Formation and Systemic Corticosteroid Therapy

1962 • 102 citations

Novel pathways for glucocorticoid effects on neutrophils in chronic inflammation

1998 • 101 citations

Low‐dose corticosteroids in rheumatoid arthritis. A meta‐analysis of their moderate‐term effectiveness

1996 • 99 citations

A randomised trial of differentiated prednisolone treatment in active rheumatoid arthritis. Clinical benefits and skeletal side effects

1999 • 98 citations

Glucocorticoid-induced osteoporosis in the lumbar spine, forearm, and mandible of nephrotic patients: A double-blind study on the high-dose, long-term effects of prednisone versus deflazacort

1992 • 93 citations

Outcome in patients with rheumatoid arthritis receiving prednisone compared to matched controls.

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Acute perforation of colonic diverticula associated with prolonged adrenocorticosteroid therapy

1971 • 93 citations

OCULAR EFFECTS OF TOPICAL AND SYSTEMIC CORTICOSTEROIDS

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Acute Pancreatitis Associated with Steroid Therapy

1961 • 92 citations

Limited bone loss due to corticosteroids; a systematic review of prospective studies in rheumatoid arthritis and other diseases.

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Effects of disease and corticosteroids on appendicular bone mass in postmenopausal women with rheumatoid arthritis: comparison with axial measurements

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Complications of long-term steroid therapy for asthma

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Empire Rheumatism Council. Cortisone/Aspirin Trial: Multi-Centre Controlled Trial Comparing Cortisone Acetate and Acetyl Salicylic Acid in the Long-Term Treatment of Rheumatoid Arthritis

1955 • 89 citations

A Comparison of Prednisolone with Aspirin or Other Analgesics in the Treatment of Rheumatoid Arthritis: Medical Research Council and Nuffield Foundation Report

1960 • 87 citations

Monocyte receptors for the Fc portion of IgG increase in number in autoimmune hemolytic anemia and other hemolytic states and are decreased by glucocorticoid therapy.

1983 • 86 citations

ORAL STEROIDS AS BRIDGE THERAPY IN RHEUMATOID ARTHRITIS PATIENTS STARTING WITH PARENTERAL GOLD. A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL

1995 • 86 citations

A Negative Regulatory Region Containing a Glucocorticosteroid Response Element (nGRE) in the Human Interleukin-1β Gene

1997 • 82 citations

Prednisone treatment of elderly‐onset rheumatoid arthritis

1995 • 77 citations

Variations in glucocorticoid induced osteoporosis prevention in a managed care cohort.

2001 • 76 citations

Glucocorticoid-Induced Apoptosis and Regulation of NF-κB Activity in Human Leukemic T Cells*

1998 • 75 citations

Moderate-term, low-dose corticosteroids for rheumatoid arthritis

1998 • 72 citations

Regulation of ?V?3 and ?V?5 integrins by dexamethasone in normal human osteoblastic cells

2000 • 69 citations

Prevention of Glucocorticoid-Induced Osteoporosis

2001 • 67 citations

Neutrophil trafficking into inflamed joints in patients with rheumatoid arthritis, and the effects of methylprednisolone

1996 • 67 citations

A Comparison of Cortisone and Aspirin in the Treatment of Early Cases of Rheumatoid Arthritis

1954 • 67 citations

Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.

1976 • 67 citations

Pituitary adrenal function during corticosteroid withdrawal in rheumatoid arthritis.

1967 • 66 citations

Colon perforations associated with steroid therapy.

1974 • 66 citations

Effects of pulse methylprednisolone on cell adhesion molecules in the synovial membrane in rheumatoid arthritis. Reduced E‐selectin and intercellular adhesion molecule 1 expression

1996 • 65 citations

LONG-TERM STUDY OF MANAGEMENT OF RHEUMATOID ARTHRITIS

1984 • 64 citations

Joint swelling as a predictor of death from cardiovascular disease in a population study of Pima Indians

2001 • 64 citations

Does Long-Term Low-Dose Corticosteroid Therapy Cause Hypertension?

1981 • 63 citations

Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis

1998 • 62 citations

Inhaled and oral corticosteroids: their effects on bone mineral density in older adults.

1995 • 59 citations

The influence of prednisolone on the recirculation of peripheral blood lymphocytes in vivo

1990 • 58 citations

Effect of low doses of deflazacort vs prednisone on bone mineral content in premenopausal rheumatoid arthritis.

1992 • 56 citations

Adrenalectomy decreases lipocortin-I messenger ribonucleic acid and tissue protein content in rats.

1992 • 55 citations

RHEUMATOID PATIENTS AFTER FIVE OR MORE YEARS OF CORTICOSTEROID TREATMENT: A COMPARATIVE ANALYSIS OF 183 CASES

1961 • 52 citations

Ocular complications in renal transplant recipients

1973 • 47 citations

Glucocorticoid Therapy for Rheumatic Diseases: Maternal, Fetal, and Breast‐Feeding Considerations

1992 • 44 citations

The clinical and immunological effects of pulse methylprednisolone therapy in rheumatoid arthritis. I. Clinical effects.

1988 • 43 citations

Steroid Cataract

1966 • 41 citations

Specific binding of lipocortin‐1 (annexin I) to monocytes and neutrophils is decreased in rheumatoid arthritis

1992 • 37 citations

Steroid-induced diabetic ketoacidosis

1971 • 35 citations

Determining causation—A case study: Adrenocorticosteroids and osteoporosis

1984 • 32 citations

Progression of radiographic joint erosion during low dose corticosteroid treatment of rheumatoid arthritis.

2000 • 30 citations

Adrenalectomy decreases lipocortin-I messenger ribonucleic acid and tissue protein content in rats

1992 • 26 citations

Practice Pattern Variation Among Internal Medicine Specialists in the Prevention of Glucocorticoid-Induced Osteoporosis

2000 • 25 citations

Osteoporosis in rheumatoid arthritis: findings in the metacarpal, spine, and hip and a study of the determinants of both localized and generalized osteopenia.

1995 • 24 citations

Glucocorticoid-Induced Apoptosis and Regulation of NF- B Activity in Human Leukemic T Cells

1998 • 22 citations

SYSTEMIC LOW-DOSE GLUCOCORTICOID TREATMENT IN RHEUMATOID ARTHRITIS

2001 • 21 citations

Endocrine control of inflammation: rheumatoid arthritis double-blind, crossover clinical trial.

1992 • 19 citations

Influence of Corticosteroids on Neutrophils, Lymphocytes, Their Subsets, and T‐Cell Activity Markers in Patients with Active Rheumatoid Arthritis, Compared to Healthy Controls

1999 • 12 citations

[On the evaluation of the effect of a combination of salicylates and prednisolone in rheumatic diseases].

1968 • 5 citations

Deleted Work

1955 • 0 citations