Effector Cells of Both Nonhemopoietic and Hemopoietic Origin Are Required for Interferon (IFN)-γ– and Tumor Necrosis Factor (TNF)-α–dependent Host Resistance to the Intracellular Pathogen, Toxoplasma gondii

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes

1996 • 1,085 citations

Immunity to Intracellular Bacteria

1993 • 1,085 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.

1996 • 663 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.

1992 • 563 citations

Inducible Nitric Oxide Is Essential for Host Control of Persistent but Not Acute Infection with the Intracellular Pathogen Toxoplasma gondii

1997 • 432 citations

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

1996 • 398 citations

Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice.

1989 • 355 citations

Interferon-Induced Proteins and the Antiviral State

1990 • 353 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation.

1993 • 345 citations

Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome

1995 • 249 citations

Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response.

1995 • 242 citations

Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes.

1994 • 207 citations

Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages

1989 • 201 citations

Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii.

1997 • 182 citations

The effect of anti-IFN-gamma antibody on the protective effect of Lyt-2+ immune T cells against toxoplasmosis in mice.

1990 • 176 citations

Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells

1996 • 171 citations

Activated Microgila Inhibit Multiplication of Toxoplasma gondii via a Nitric Oxide Mechanism

1993 • 152 citations

A Role for Activated Macrophages in Resistance to Infection with Toxoplasma

1972 • 148 citations

Decreased Resistance of TNF Receptor p55- and p75-Deficient Mice to Chronic Toxoplasmosis Despite Normal Activation of Inducible Nitric Oxide Synthase In Vivo

1998 • 145 citations

Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity by intracellular parasites.

1993 • 134 citations

Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis.

1998 • 130 citations

Listeriosis in p47phox−/− and TRp55−/− Mice: Protection Despite Absence of ROI and Susceptibility Despite Presence of RNI

1997 • 130 citations

Crucial Role of TNF Receptor Type 1 (p55), But Not of TNF Receptor Type 2 (p75), in Murine Toxoplasmosis

1998 • 119 citations

Antiparasitic and antiproliferative effects of indoleamine 2,3-dioxygenase enzyme expression in human fibroblasts

1994 • 118 citations

Interferon: Protection of Cells Infected with an Intracellular Protozoan ( Toxoplasma gondii )

1968 • 113 citations

Studies on the role of interleukin-12 in acute murine toxoplasmosis.

1995 • 111 citations

Effect of Cytokines on Growth ofToxoplasma gondiiin Murine Astrocytes

1998 • 111 citations

How Does Toxoplasma gondii Enter Host Cells?

1985 • 110 citations

Chlamydial Infection in Inducible Nitric Oxide Synthase Knockout Mice

1998 • 103 citations

Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain.

1997 • 102 citations

Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-gamma-activated murine macrophages and microglial cells.

1997 • 98 citations

Anti‐parasitic effector mechanisms in human brain tumor cells: Role of interferon‐γ and tumor necrosis factor‐α

1996 • 90 citations

Human endothelial cells are activated by IFN-gamma to inhibit Toxoplasma gondii replication. Inhibition is due to a different mechanism from that existing in mouse macrophages and human fibroblasts.

1991 • 81 citations

Mediation of immunity to intracellular infection (Toxoplasma and Besnoitia) within somatic cells

1978 • 65 citations

Antileishmanial defense in macrophages triggered by tumor necrosis factor expressed on CD4+ T lymphocyte plasma membrane.

1991 • 60 citations

Establishment of an antitoxoplasma state by stable expression of mouse indoleamine 2,3-dioxygenase

1993 • 40 citations

Why Listeriosis? A perspective on cellular immunity to infection

1997 • 36 citations

Murine gamma interferon fails to inhibit Toxoplasma gondii growth in murine fibroblasts

1990 • 31 citations

Inducible Nitric Oxide Synthase Is Not Required for Long-Term Vaccine-Based Immunity AgainstToxoplasma gondii

1998 • 28 citations

Growth inhibition of Toxoplasma gondii in cell cultures treated with murine type II interferon.

1982 • 9 citations