CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans.

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Mutagens-carcinogens in foods.

1983 • 372 citations

Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

1991 • 340 citations

Meat, cooking methods and colorectal cancer: A case‐referent study in Stockholm

1991 • 325 citations

Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.

1990 • 291 citations

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

1990 • 280 citations

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1989 • 265 citations

Identification of the mutagens in cooked beef.

1986 • 244 citations

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O‐deethylation of phenacetin and is inducible by cigarette smoking.

1988 • 236 citations

The lessons of life: keynote address to the nutrition and cancer conference.

1992 • 200 citations

Induction of Lymphoma in CDF₁ Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1989 • 186 citations

Heterocyclic-Amine Mutagens/Carcinogens in Foods

1990 • 186 citations

Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods

1987 • 152 citations

Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors

1990 • 109 citations

Differential expression and regulation of members of the cytochrome P450IA gene subfamily in human tissues

1990 • 105 citations

Role of sulfation and acetylation in the activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind DNA

1990 • 104 citations

Measurement of MeIQx and DiMeIQx in fried beef by capillary column gas chromatography electron capture negative ion chemical ionisation mass spectrometry

1988 • 75 citations

Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450

1988 • 63 citations

Induction of Intestinal Adenocarcinomas by 2‐Amino‐l‐methyl‐6‐phenylimidazo‐[4,5‐b] pyridine in Nagase Analbuminemic Rats

1991 • 60 citations

Activation of the food-derived mutagen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by rabbit and human liver microsomes and purified forms of cytochrome P-450

1989 • 59 citations

Accumulation of caffeine in healthy volunteers treated with furafylline.

1987 • 58 citations

Induction of Aberrant Crypt Foci in the Large Intestine of F344 Rats by Oral Administration of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1991 • 54 citations

High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

1990 • 53 citations

The effect of dose and cytochrome P450 induction on the metabolism and disposition of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-fquinoxaline (MeIQx) in the rat

1991 • 38 citations

The contribution of N-oxidation to the metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat hepatocytes

1990 • 36 citations

Disposition and metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline (MeIQx) in rats

1989 • 35 citations

The effect of dose and enzyme inducers on the metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats

1991 • 33 citations

Metabolic activation and genotoxicity of heterocyclic arylamines.

1992 • 31 citations

Combined assay for phenacetin and paracetamol in plasma using capillary column gas chromatography—negative-ion mass spectrometry

1991 • 29 citations

An assay for paracetamol, produced by the O-deethylation of phenacetinin vitro, using gas chromatography/electron capture negative ion chemical ionization mass spectrometry

1986 • 26 citations

An animal model for the detection of drug-induced inhibition of caffeine metabolism.

1987 • 5 citations

Specificity and inducibility of cytochrome P-450 catalysing the activation of food-derived mutagenic heterocyclic amines

1991 • 4 citations