Topoisomerase II inhibitor-induced apoptosis in thymocytes and lymphoma cells

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA TOPOISOMERASES

1996 • 1,771 citations

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1975 • 1,734 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

DNA Topoisomerases: Essential Enzymes and Lethal Targets

1994 • 722 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

1995 • 501 citations

RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing.

1994 • 481 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

THE ROLE OF THE NUCLEAR MATRIX IN THE ORGANIZATION AND FUNCTION OF DNA

1986 • 360 citations

Inhibitors of DNA topoisomerases

1988 • 340 citations

Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.

1994 • 339 citations

DNA Topoisomerases: Enzymes That Control DNA Conformation

1985 • 337 citations

Perspectives on mammalian cell death

1988 • 334 citations

Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.

1991 • 287 citations

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.

1987 • 282 citations

Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.

1989 • 242 citations

Radiation-induced Interphase Death of Rat Thymocytes is Internally Programmed (Apoptosis)

1988 • 239 citations

A simple subtractive hybridization technique employing photoactivatable biotin and phenol extraction

1988 • 219 citations

Perspectives on mammalian cell death.

1987 • 183 citations

A model for tumor cell killing by topoisomerase poisons.

1990 • 172 citations

Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events.

1994 • 157 citations

Sequence-specific DNA-binding proteins are components of a nuclear matrix-attachment site.

1992 • 130 citations

Protein phosphorylation in apoptosis

1995 • 107 citations

cDNA cloning of human hnRNP protein Al reveals the existence of multiple mRNA isoforms

1988 • 107 citations

Distinct mechanisms of regulation of protein kinase C epsilon by hormones and phorbol diesters.

1991 • 107 citations

Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle

1996 • 97 citations

Specificity and Functional Significance of DNA Interaction with the Nuclear Matrix: New Approaches to Clarify the Old Questions

1996 • 95 citations

The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells.

1990 • 90 citations

Topoisomerase inhibitors induce apoptosis in thymocytes

1993 • 87 citations

Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide.

1992 • 85 citations

Activation of Programmed Cell Death by Recombinant Human Tumor Necrosis Factor Plus Topoisomerase II - Targeted Drugs in L929 Tumor Cells

1991 • 70 citations

Teniposide-resistant CEM cells, which express mutant DNA topoisomerase II alpha, when treated with non-complex-stabilizing inhibitors of the enzyme, display no cross-resistance and reveal aberrant functions of the mutant enzyme.

1993 • 67 citations

Different modes of anthracycline interaction with topoisomerase II

1993 • 67 citations

Discrete Localization of Different DNA Topoisomerases in HeLa and K562 Cell Nuclei and Subnuclear Fractions

1994 • 61 citations

Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26.

1995 • 57 citations

Molecular cloning and sequence analysis of cDNA encoding δ⁴-3-ketosteroid 5β-reductase of rat liver

1991 • 47 citations

Downregulation of Protein Kinase C Suppresses Induction of Apoptosis in Human Prostatic Carcinoma Cells

1996 • 40 citations

Effects of Protein Tyrosine Kinase Inhibitors with Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2 Cells1

1995 • 35 citations

An Assay Method for DNA Topoisomerase Activity Based on Separation of Relaxed DNA from Supercoiled DNA Using High-Performance Liquid Chromatography

1993 • 30 citations

Subcellular distribution of the α and β topoisomerase II-DNA complexes stabilized by VM-26

1994 • 24 citations

Thymocyte Apoptosis

1993 • 12 citations

The Involvement of Apoptosis in Etoposide-Induced Thymic Atrophy

1994 • 11 citations

bis(2,6-dioxopiperaxine) derivatives, topoisomerase II inhibitors which do not form a DNA cleavable complex, induce thymocyte apoptosis.

1994 • 9 citations