Clonal and non-clonal chromosome aberrations and genome variation and aberration

The Sequence of the Human Genome

2001 • 13,500 citations

Initial sequencing and comparative analysis of the mouse genome

2002 • 6,971 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

2003 • 6,017 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Epigenetics in human disease and prospects for epigenetic therapy

2004 • 3,142 citations

Detection of large-scale variation in the human genome

2004 • 2,876 citations

Chromosome territories, nuclear architecture and gene regulation in mammalian cells

2001 • 2,239 citations

The epigenetic progenitor origin of human cancer

2005 • 1,839 citations

Multicolor Spectral Karyotyping of Human Chromosomes

1996 • 1,780 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

Karyotyping human chromosomes by combinatorial multi-fluor FISH

1996 • 1,265 citations

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

2000 • 1,077 citations

Active genes dynamically colocalize to shared sites of ongoing transcription

2004 • 1,023 citations

Chromosome aberrations in solid tumors

2003 • 805 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

Aneuploidy and cancer

2004 • 710 citations

Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps

2005 • 589 citations

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B

2004 • 588 citations

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

2001 • 552 citations

High-resolution mapping of mammalian genes by in situ hybridization to free chromatin.

1992 • 514 citations

Histone H2AX

2003 • 479 citations

Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

2005 • 469 citations

Chromosomal Speciation and Molecular Divergence--Accelerated Evolution in Rearranged Chromosomes

2003 • 444 citations

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

2001 • 422 citations

Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines

2005 • 382 citations

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

2000 • 351 citations

Recurrent chromosome aberrations in cancer

2000 • 337 citations

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

2005 • 335 citations

DNA double strand break repair and chromosomal translocation: Lessons from animal models

2001 • 323 citations

Contributions of low molecule number and chromosomal positioning to stochastic gene expression

2005 • 321 citations

Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation

2000 • 315 citations

Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study

1995 • 312 citations

Chromosome translocations: dangerous liaisons revisited

2001 • 272 citations

A functional marker centromere with no detectable alpha-satellite, satellite III, or CENP-B protein: activation of a latent centromere?

1993 • 261 citations

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

1990 • 256 citations

Human cytogenetics: 46 chromosomes, 46 years and counting

2002 • 223 citations

Chromatin loops are selectively anchored using scaffold/matrix-attachment regions

2004 • 199 citations

Genomic instability and apoptosis are frequent in p53 deficient young mice

1997 • 197 citations

Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective

2004 • 193 citations

The Chromosomal Basis of Cancer

2005 • 179 citations

Impaired Nonhomologous End-Joining Provokes Soft Tissue Sarcomas Harboring Chromosomal Translocations, Amplifications, and Deletions

2001 • 173 citations

The Cellular Basis of Tumor Progression

1997 • 163 citations

Stochastic cancer progression driven by non‐clonal chromosome aberrations

2006 • 156 citations

Genomic mechanisms and measurement of structural and numerical instability in cancer cells

2006 • 144 citations

Insights into the carcinogenic mode of action of arsenic

2006 • 108 citations

Bloom's syndrome and Fanconi's anemia: Demonstration of two distinctive patterns of chromosome disruption and rearrangement

1974 • 108 citations

Multivariate analyses of genomic imbalances in solid tumors reveal distinct and converging pathways of karyotypic evolution

2001 • 105 citations

Sequence analysis of the protein kinase gene family in human testicular germ‐cell tumors of adolescents and adults

2005 • 104 citations

From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics.

2003 • 101 citations

Regulation of meiotic chromatin loop size by chromosomal position.

1996 • 99 citations

Untangling the Roots of Cancer

2003 • 97 citations

Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations

2001 • 97 citations

Cancer genome sequencing: The challenges ahead

2007 • 95 citations

Genetic and Epigenetic Changes in Mammary Epithelial Cells May Mimic Early Events in Carcinogenesis

2004 • 84 citations

Cancer progression by non‐clonal chromosome aberrations

2006 • 82 citations

ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development

2005 • 76 citations

Elimination of altered karyotypes by sexual reproduction preserves species identity

2007 • 72 citations

Organization of heterologous DNA inserts on the mouse meiotic chromosome core

1994 • 71 citations

Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition.

2002 • 65 citations

Karyotypic relationships of horses and zebras: results of cross-species chromosome painting

2003 • 64 citations

Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells

2005 • 61 citations

Imaging genome abnormalities in cancer research.

2004 • 60 citations

Fish technology in chromosome and genome research

1997 • 58 citations

Studies of mitotic and centromeric abnormalities in Roberts syndrome: Implications for a defect in the mitotic mechanism

1991 • 58 citations

Statistical behavior of complex cancer karyotypes

2005 • 57 citations

Re-defining the chromatin loop domain

2001 • 57 citations

High resolution free chromatin/DNA fiber fluorescent in situ hybridization

1998 • 48 citations

Formation of chromosome aberrations: insights from FISH

2003 • 46 citations

Chromosomics

2005 • 39 citations

Analysis of marker or complex chromosomal rearrangements present in pre‐ and post‐natal karyotypes utilizing a combination of G‐banding, spectral karyotyping and fluorescence in situ hybridization

2003 • 35 citations

Effects of pingyanymycin on chromosomes: A possible structural basis for chromosome aberration

1988 • 30 citations

Mutagen sensitivity as a marker of cancer risk.

1994 • 27 citations

The combination of SKY and specific loci detection with FISH or immunostaining

2001 • 26 citations

Acetylsalicylic acid exhibits anticlastogenic effects on cultured human lymphocytes exposed to doxorubicin

2006 • 21 citations

Combined multicolor-FISH and immunostaining

2006 • 21 citations

Epigenetics and the renaissance of heresy

2003 • 18 citations

Nontargeted Stable Integration of Recombinant Adeno-Associated Virus into Human Leukemia and Lymphoma Cell Lines as Evaluated by Fluorescence in Situ Hybridization

1999 • 10 citations

Mutagen-Induced Chromatid Breakage as a Marker of Cancer Risk

2004 • 7 citations

A Mathematical Model Relating Chromosome Aberrations to Cancer Progression

2006 • 2 citations