Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

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2001 • 3,867 citations

Glutamate receptor ion channels

2005 • 3,667 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1

1997 • 1,715 citations

Localization of neuronal and glial glutamate transporters

1994 • 1,668 citations

The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury

1989 • 1,505 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

2005 • 1,433 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.

1989 • 1,110 citations

Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury

1990 • 1,080 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

1997 • 909 citations

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1995 • 884 citations

Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry

1995 • 821 citations

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

2002 • 693 citations

Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis

1998 • 663 citations

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1990 • 630 citations

Glutamate Release and Free Radical Production Following Brain Injury: Effects of Posttraumatic Hypothermia

1995 • 616 citations

The metabotropic glutamate receptors, MGLUR2 and MGLUR3, show unique postsynaptic, presynaptic and glial localizations

1996 • 584 citations

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1993 • 569 citations

Factors affecting excitatory amino acid release following severe human head injury

1998 • 515 citations

Brain Glutamate Transporter Proteins Form Homomultimers

1996 • 471 citations

Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease

1996 • 437 citations

An [Na+ + K+]coupledl-glutamate transporter purified from rat brain is located in glial cell processes

1992 • 429 citations

Traumatic Brain Injury‐Induced Excitotoxicity Assessed in a Controlled Cortical Impact Model

1993 • 409 citations

The Glutamate Transporter EAAT4 in Rat Cerebellar Purkinje Cells: A Glutamate-Gated Chloride Channel Concentrated near the Synapse in Parts of the Dendritic Membrane Facing Astroglia

1998 • 346 citations

Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration

1997 • 332 citations

Glutamate Transporter Alterations in Alzheimer Disease Are Possibly Associated with Abnormal APP Expression

1997 • 325 citations

Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation

2002 • 312 citations

Characterization of edema by diffusion-weighted imaging in experimental traumatic brain injury

1996 • 271 citations

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

2003 • 269 citations

The Glutamate Transporter GLT1a Is Expressed in Excitatory Axon Terminals of Mature Hippocampal Neurons

2004 • 255 citations

Administration of Excitatory Amino Acid Antagonists via Microdialysis Attenuates the Increase in Glucose Utilization Seen following Concussive Brain Injury

1992 • 249 citations

Traumatic Brain Injury Down‐Regulates Glial Glutamate Transporter (GLT‐1 and GLAST) Proteins in Rat Brain

1998 • 226 citations

The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms

2000 • 216 citations

Expression of a Variant Form of the Glutamate Transporter GLT1 in Neuronal Cultures and in Neurons and Astrocytes in the Rat Brain

2002 • 205 citations

4‐Hydroxynonenal, a Lipid Peroxidation Product, Rapidly Accumulates Following Traumatic Spinal Cord Injury and Inhibits Glutamate Uptake

1997 • 191 citations

Lactate accumulation following concussive brain injury: the role of ionic fluxes induced by excitatory amino acids

1995 • 187 citations

Glial swelling following human cerebral contusion: an ultrastructural study.

1991 • 185 citations

Selective Interaction of Complexin with the Neuronal SNARE Complex

2000 • 171 citations

Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with dl-threo-β-benzyloxyaspartate

2000 • 163 citations

Evidence for Prolonged Release of Excitatory Amino Acids in Severe Human Head Trauma

1995 • 162 citations

Astrocytic Swelling Due to Hypotonic or High K⁺Medium Causes Inhibition of Glutamate and Aspartate Uptake and Increases Their Release

1995 • 161 citations

A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system

2002 • 153 citations

Comparative analysis of glutamate transporter expression in rat brain using differential double in situ hybridization

1998 • 149 citations

Activation of Class II or III Metabotropic Glutamate Receptors Protects Cultured Cortical Neurons Against Excitotoxic Degeneration

1995 • 147 citations

Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampus

1995 • 145 citations

Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat

2001 • 132 citations

The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals

1999 • 128 citations

Defining Ischemic Burden after Traumatic Brain Injury Using ¹⁵O PET Imaging of Cerebral Physiology

2004 • 125 citations

Development of Prolonged Focal Cerebral Edema and Regional Cation Changes Following Experimental Brain Injury in the Rat

1992 • 120 citations

Monitoring the Impact of Traumatic Brain Injury: A Review and Update

1995 • 119 citations

Tissue specific variants of glutamate transporter GLT‐1

1997 • 115 citations

Intracranial haemorrhage induced at arterial pressure in the rat: Part 2: Short term changes in local cerebral blood flow measured by autoradiography

1984 • 112 citations

Glutamate transporter EAAC1 is expressed in neurons and glial cells in the rat nervous system

1999 • 109 citations

Antisense knockdown of the glial glutamate transporter GLT-1 exacerbates hippocampal neuronal damage following traumatic injury to rat brain

2001 • 107 citations

Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats

1997 • 106 citations

Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia

2000 • 99 citations

Cloning, transport properties, and differential localization of two splice variants of GLT‐1 in the rat CNS: Implications for CNS glutamate homeostasis

2003 • 98 citations

Effects of mild hypothermia on cerebral blood flow-independent changes in cortical extracellular levels of amino acids following contusion trauma in the rat

1997 • 88 citations

Cerebral blood flow in severe clinical head injury.

1995 • 84 citations

Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients

1998 • 81 citations

Glutamate efflux via the reversal of the sodium-dependent glutamate transporter caused by glycolytic inhibition in rat cultured astrocytes

1994 • 80 citations

Action of Complexin on SNARE Complex

2002 • 80 citations

Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for Group II metabotropic glutamate receptors against intraventricular kainate in the rat

1997 • 72 citations

Intracerebral microdialysis combined with recording of extracellular field potential: a novel method for investigation of depolarizing drugs in vivo

1994 • 62 citations

Chapter 4 Excitotoxin-mediated neuron death in youth and old age

1990 • 60 citations

Early loss of the glutamate transporter splice‐variant GLT‐1v in rat cerebral cortex following lateral fluid‐percussion injury

2004 • 59 citations

Distribution of two splice variants of the glutamate transporter GLT‐1 in rat brain and pituitary

2002 • 59 citations

Knocking out the glial glutamate transporter GLT‐1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia

2002 • 58 citations

Decrease in Glial Glutamate Transporter Variants and Excitatory Amino Acid Receptor Down-Regulation in a Murine Model of ALS-PDC

2003 • 56 citations

Significance of a Reduced Cerebral Blood Flow During the First 12 Hours After Traumatic Brain Injury

2004 • 53 citations

Uncoupling of Cerebral Blood Flow and Metabolism after Cerebral Contusion in the Rat

2001 • 52 citations

N-acetylcysteine attenuates early induction of heme oxygenase-1 following traumatic brain injury

2005 • 51 citations

The Amino Terminus of the Glial Glutamate Transporter GLT-1 Interacts with the LIM Protein Ajuba

2002 • 51 citations

Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl termini

2004 • 49 citations

Early, Transient Increase in Complexin I and Complexin II in the Cerebral Cortex following Traumatic Brain Injury Is Attenuated byN-Acetylcysteine

2006 • 48 citations

The Effect of Groups II and III Metabotropic Glutamate Receptor Activation on Neuronal Injury in a Rodent Model of Traumatic Brain Injury

2001 • 39 citations

MINOR HEAD TRAUMA

1998 • 38 citations

Traumatic brain injury: Developmental differences in glutamate receptor response and the impact on treatment

2001 • 31 citations

Primary and secondary brain injury

2005 • 20 citations