Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Current protocols in molecular biology

1988 • 4,543 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

[1] Production of single-stranded plasmid DNA

1987 • 2,642 citations

DNA sequence and expression of the B95-8 Epstein—Barr virus genome

1984 • 2,039 citations

Rapid similarity searches of nucleic acid and protein data banks.

1983 • 1,577 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Synthetic oligonucleotide probes deduced from amino acid sequence data

1985 • 759 citations

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.

1982 • 737 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

BIOSYNTHESIS AND METABOLISM OF TETRAHYDROBIOPTERIN AND MOLYBDOPTERIN

1985 • 542 citations

Nucleotide sequence of the E. coli gene coding for dihydrofolate reductase

1980 • 378 citations

Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1

1986 • 335 citations

A New Pteridine-requiring Enzyme System for the Oxidation of Glyceryl Ethers

1964 • 294 citations

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

1985 • 273 citations

Crystal structure of human dihydrofolate reductase complexed with folate

1988 • 219 citations

Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-γ

1989 • 201 citations

Site specificity of casein kinase‐2 (TS) from rat liver cytosol

1986 • 193 citations

Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.

1982 • 184 citations

Tetrahydrobiopterin in Striatum: Localization in Dopamine Nerve Terminals and Role in Catecholamine Synthesis

1981 • 182 citations

In vivo enhancement of tyrosine hydroxylation in rat striatum by tetrahydrobiopterin

1974 • 180 citations

Metabolism of the Phenylalanine Hydroxylation Cofactor

1967 • 179 citations

Serum-stimulated cell growth causes oscillations in casein kinase II activity

1989 • 171 citations

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major.

1986 • 165 citations

Biosynthesis and metabolism of pterins in peripheral blood mononuclear cells and leukemia lines of man and mouse

1987 • 130 citations

Biopterin Cofactor Biosynthesis: Independent Regulation of GTP Cyclohydrolase in Adrenal Medulla and Cortex

1981 • 107 citations

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins.

1986 • 92 citations

Pteridine Cofactors

1967 • 91 citations

The structure of mouse L1210 dihydrofolate reductase‐drug complexes and the construction of a model of human enzyme

1987 • 89 citations

Tetrahydrobiopterin, the cofactor for aromatic amino acid hydroxylases, is synthesized by and regulates proliferation of erythroid cells.

1989 • 88 citations

The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase

1983 • 74 citations

Chapter 13. Methods for the Assessment of Site-Specific Histone Phosphorylation

1978 • 74 citations

Purification and Characterization of Rat Liver GTP Cyclohydrolase I

1989 • 73 citations

GENAS: a database system for nucleic add sequence analysis

1984 • 60 citations

The biosynthesis of tetrahydrobiopterin in rat brain

1989 • 55 citations

Amino-Acid Sequence of Dihydrofolate Reductase from a Methotrexate-resistant Mutant of Streptococcus faecium and Identification of Methionine Residues at the Inhibitor Binding Site

1974 • 54 citations

Histone H1 kinase in exponential and synchronous populations of Chinese hamster fibroblasts.

1986 • 47 citations

Inhibition of GTP cyclohydrolase I by pterins

1988 • 41 citations

Guanosine triphosphate cyclohydrolase activity in rat tissues

1984 • 31 citations

Nucleotide sequence of the dihydrofolate reductase gene of Saccharomyces cerevisiae

1988 • 27 citations