"ON-OFF" EFFECTS IN PATIENTS WITH PARKINSON'S DISEASE ON CHRONIC LEVODOPA THERAPY

Aromatic Amino Acids and Modification of Parkinsonism

1967 • 1,464 citations

Tetrahydroisoquinoline Alkaloids: in vivo Metabolites of L-Dopa in Man

1973 • 369 citations

Bromocriptine in Parkinsonism

1974 • 311 citations

“On‐off” phenomenon with levodopa therapy in parkinsonism

1974 • 232 citations

Injected Apomorphine and Orally Administered Levodopa in Parkinsonism

1972 • 130 citations

Patterns of clinical response and plasma dopa levels in Parkinson's disease

1975 • 111 citations

The clinical physiology of side effects in long-term L-DOPA therapy.

1974 • 96 citations

Start Hesitation — A Side Effect of Long-Term Levodopa Therapy

1973 • 90 citations

LONG-TERM SIDE-EFFECTS OF LEVODOPA

1971 • 85 citations

IDIOPATHIC PARKINSONISM TREATED WITH BROMOCREPTINE

1975 • 73 citations

Plasma dopa concentrations and the “on‐off” effect after chronic treatment of Parkinson's disease

1974 • 72 citations

A YEAR'S COMPARISON OF TREATMENT OF PATIENTS WITH PARKINSON'S DISEASE WITH LEVODOPA COMBINED WITH CARBIDOPA VERSUS TREATMENT WITH LEVODOPA ALONE

1973 • 59 citations

Effects of L-dopa metabolites at a dopamine receptor suggest a basis for ‘on-off’ effect in Parkinson's disease

1975 • 57 citations

Relationship between animal models and clinical parkinsonism.

1975 • 52 citations

SUSTAINED LEVODOPA THERAPY IN PARKINSONISM

1973 • 50 citations

The "on-off" response to chronic L-DOPA treatment of Parkinsonism.

1974 • 40 citations

"On-Off" Phenomena Related to High Plasma Levodopa

1973 • 27 citations

BROMOCRIPTINE IN PARKINSONISM

1975 • 25 citations

Variations in the "on-off" effect.

1974 • 24 citations

DIPHASIC DYSKINESIA DURING LEVODOPA THERAPY

1975 • 23 citations

BROMOCRIPTINE IN PARKINSONISM

1975 • 22 citations

Treatment of "On-Off Effect" With A Dopa Decarboxylase Inhibitor

1975 • 19 citations

APPRAISAL OF LONG-TERM LEVODOPA TREATMENT OF PARKINSONISM WITH SPECIAL REFERENCE TO THERAPY LIMITING FACTORS

2009 • 17 citations

The "on-off" side effect of L-DOPA.

1974 • 17 citations

Short- and long-term approaches to the "on-off" phenomenon.

1974 • 15 citations

SERUM-MONOAMINE-OXIDASE LEVELS DURING LEVODOPA THERAPY

1971 • 13 citations

DYSKINESIAS DURING LEVODOPA THERAPY

1975 • 10 citations

The Clinical Uses of Levodopa

1976 • 8 citations

BLOOD CATECHOL-O-METHYLTRANSFERASE ACTIVITY IN PARKINSON'S DISEASE

1971 • 8 citations