Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Peptides: Chemistry, structure and biology

1977 • 799 citations

Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

1979 • 684 citations

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

1981 • 503 citations

EFFECT OF MORPHINE ON ADRENERGIC TRANSMISSION IN THE MOUSE VAS DEFERENS. ASSESSMENT OF AGONIST AND ANTAGONIST POTENCIES OF NARCOTIC ANALGESICS

1975 • 406 citations

Classification of multiple morphine and enkephalin binding sites in the central nervous system.

1981 • 372 citations

The effects of adrenaline, noradrenaline and isoprenaline on inhibitory α‐ and β‐adrenoceptors in the longitudinal muscle of the guinea‐pig ileum

1970 • 360 citations

EFFECTS OF CHANGES IN THE STRUCTURE OF ENKEPHALINS AND OF NARCOTIC ANALGESIC DRUGS ON THEIR INTERACTIONS WITH μ‐ AND δ‐RECEPTORS

1980 • 314 citations

SPECTRUM OF THE μ‐, δ‐ AND κ‐BINDING SITES IN HOMOGENATES OF RAT BRAIN

1982 • 278 citations

Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogs: effect of conformational constraints on opiate receptor selectivity

1982 • 199 citations

Conformation of Met5-enkephalin determined by high field PMR spectroscopy

1976 • 171 citations

Deltakephalin, Tyr-D-Thr-Gly-Phe-Leu-Thr: A new highly potent and fully specific agonist for opiate δ-receptors

1983 • 169 citations

D‐Tyr—Ser—Gly—Phe—Leu—Thr, a highly preferential ligand for δ‐opiate receptors

1980 • 165 citations

COMPARISON OF THE BINDING CHARACTERISTICS OF TRITIATED OPIATES AND OPIOID PEPTIDES

1980 • 155 citations

Proton magnetic resonance studies of conformation and flexibility of enkephalin peptides

1976 • 151 citations

U-50488H, a pure kappa receptor agonist with spinal analgesic loci in the mouse

1982 • 139 citations

A cyclic enkephalin analog with high in vitro opiate activity.

1980 • 124 citations

Dimeric tetrapeptide enkephalins display extraordinary selectivity for the δ opiate receptor

1982 • 112 citations

Conformational states of enkephalins in solution

1977 • 111 citations

Cyclic enkephalin analogs containing a cystine bridge

1981 • 97 citations

Conformationally constrained cyclic enkephalin analogs with pronounced delta opioid receptor agonist selectivity

1983 • 96 citations

Relative conformational rigidity in oxytocin and (1-penicillamine)-oxytocin: a proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism.

1977 • 89 citations

Structural requirements for specific recognition of mu or delta opiate receptors.

1981 • 73 citations

[D-Pen2, L-cys5]enkephalinamide and [D-pen2, D-cys5]enkephalinamide, conformationally constrained cyclic enkephalinamide analogs with delta receptor specificity

1982 • 68 citations

Conformational study of the potent peptide hormone antagonist [1-penicillamine,2-leucine]oxytocin in aqueous solution

1981 • 33 citations