Angiotensin II activates MAPK and stimulates growth of human pulmonary artery smooth muscle via AT₁receptors

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.

1988 • 1,077 citations

The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.

1995 • 918 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells.

1994 • 314 citations

Effects of angiotensin II and vasopressin on human smooth muscle cells in vitro

1981 • 306 citations

Identification of an Essential Signaling Cascade for Mitogen-activated Protein Kinase Activation by Angiotensin II in Cultured Rat Vascular Smooth Muscle Cells

1996 • 263 citations

Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo.

1994 • 246 citations

Pharmacology of smooth muscle cell replication.

1992 • 225 citations

Role of angiotensin subtype 2 receptor in neointima formation after vascular injury.

1992 • 221 citations

Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.

1995 • 211 citations

Changes in expression of angiotensin receptor subtypes in the rat aorta during development

1991 • 203 citations

Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension

1995 • 183 citations

Differential distribution of angiotensin AT2 receptors in the normal and failing human heart.

1998 • 159 citations

Angiotensin II induces delayed mitogenesis and cellular proliferation in rat aortic smooth muscle cells. Correlation with the expression of specific endogenous growth factors and reversal by suramin.

1994 • 150 citations

Induction of the proto-oncogene c-jun by angiotensin II.

1990 • 143 citations

Cell Type–Specific Angiotensin II–Evoked Signal Transduction Pathways

1998 • 141 citations

Smooth Muscle Cell Heterogeneity in Pulmonary and Systemic Vessels

1997 • 131 citations

Captopril in primary pulmonary hypertension.

1983 • 101 citations

Pulmonary Artery Remodeling Differs in Hypoxia- and Monocrotaline-induced Pulmonary Hypertension

1998 • 96 citations

Prevention of pulmonary vascular changes of chronic alveolar hypoxia by inhibition of angiotensin I-converting enzyme in the rat.

1975 • 90 citations

Regional Changes in Angiotensin II Receptor Density after Experimental Myocardial Infarction

1996 • 76 citations

Short- and Long-term Hemodynamic Effects of Captopril in Patients with Pulmonary Hypertension and Selected Connective Tissue Disease

1992 • 75 citations

Angiotensin II (AT1) vascular binding sites in human placentae from normal-term, preeclamptic and growth retarded pregnancies.

1994 • 62 citations

Angiotensin II increases proto-oncogene expression and phosphoinositide turnover in vascular smooth muscle cells via the angiotensin II AT1 receptor

1992 • 62 citations

Angiotensin-converting Enzyme Inhibition Delays Pulmonary Vascular Neointimal Formation

1998 • 60 citations

Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung

1996 • 54 citations

Automatic sizing and separation of particles by ratios of light scattering intensities.

1976 • 48 citations

Angiotensin converting enzyme expression in primary pulmonary hypertension.

1996 • 46 citations

Mitogenic Effect of Angiotensin II on Rat Carotid Arteries and Type II or III Mesenteric Microvessels but Not Type I Mesenteric Microvessels Is Mediated by Endogenous Basic Fibroblast Growth Factor

1998 • 39 citations

Angiotensin II and monocrotaline-induced pulmonary hypertension: effect of losartan (DuP 753), a nonpeptide angiotensin type 1 receptor antagonist.

1992 • 38 citations

Developmental regulation of angiotensin converting enzyme and angiotensin type 1 receptor in the rat pulmonary circulation.

1996 • 36 citations

Effect of angiotensin II receptor blocker on angiotensin II stimulated dna synthesis of cultured human aortic smooth muscle cells

1995 • 33 citations

Effect of Angiotensin II on Human Vascular Smooth Muscle Cell Growth

1994 • 28 citations

The effect of angiotensin II on DNA synthesis varies considerably in vascular smooth muscle cells from different Wistar???Kyoto rats

1992 • 25 citations

Persistent hemodynamic and clinical improvement after captopril in patients with pulmonary hypertension.

1986 • 20 citations

5‐Hydroxytryptamine, angiotensin and bradykinin transiently increase intracellular calcium concentrations and PKC‐α activity, but do not induce mitogenesis in human vascular smooth muscle cells

1997 • 19 citations

Vascular hypertrophy and hypertension: a role for growth factors?

1988 • 10 citations