An Effector Site That Stimulates G-protein GTPase in Photoreceptors

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology.

1991 • 909 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments.

1979 • 448 citations

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1992 • 324 citations

Molecular mechanism of visual transduction

1989 • 312 citations

Assembly and function of a quaternary signal transduction complex monitored by surface plasmon resonance

1993 • 252 citations

The isolation and purification of osmotically intact discs from retinal rod outer segments

1975 • 248 citations

Characterization and Analysis of Frog Photoreceptor Membranes

1971 • 187 citations

Membrane-dependent guanine nucleotide binding and GTPase activities of soluble protein from bovine rod cell outer segments.

1979 • 183 citations

Separate GTP Binding and GTPase Activating Domains of a Gα Subunit

1993 • 172 citations

A GTPase-accelerating factor for transducin, distinct from its effector cGMP phosphodiesterase, in rod outer segment membranes

1993 • 133 citations

Regulation of transducin GTPase activity in bovine rod outer segments.

1994 • 131 citations

Mechanism of GTP hydrolysis by G-protein alpha subunits.

1994 • 117 citations

Enhancement of rod outer segment GTPase accelerating protein activity by the inhibitory subunit of cGMP phosphodiesterase.

1994 • 115 citations

cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse.

1991 • 102 citations

Retinal rod GTPase turnover rate increases with concentration: A key to the control of visual excitation?

1987 • 93 citations

Signal transduction enzymes of vertebrate photoreceptors

1992 • 89 citations

Interaction between the retinal cyclic GMP phosphodiesterase inhibitor and transducin. Kinetics and affinity studies

1993 • 81 citations

Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism.

1992 • 81 citations

Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase

1992 • 79 citations

Enhanced GTPase activity of transducin when bound to cGMP phosphodiesterase in bovine retinal rods.

1992 • 79 citations

Interaction of GTPase activating proteins (GAPs) with p21ras measured by a novel fluorescence anisotropy method. Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras

1993 • 78 citations

Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments

1989 • 70 citations

Sub‐second turnover of transducin GTPase in bovine rod outer segments A light scattering study

1988 • 70 citations

Active sites of the cyclic GMP phosphodiesterase γ‐subunit of retinal rod outer segments

1988 • 69 citations

Activation and solubilization of the retinal cGMP‐specific phosphodiesterase by limited proteolysis

1991 • 67 citations

Functional regions of the inhibitory subunit of retinal rod cGMP phosphodiesterase identified by site-specific mutagenesis and fluorescence spectroscopy

1992 • 66 citations

The Carboxyl Terminus of the γ-Subunit of Rod cGMP Phosphodiesterase Contains Distinct Sites of Interaction with the Enzyme Catalytic Subunits and the α-Subunit of Transducin

1995 • 64 citations

Enhancement by phosphodiesterase subunits of the rate of GTP hydrolysis by transducin in bovine retinal rods. Essential role of the phosphodiesterase catalytic core.

1993 • 63 citations

Expression in bacteria of functional inhibitory subunit of retinal rod cGMP phosphodiesterase.

1989 • 62 citations

Interaction of the γ-subunit of retinal rod outer segment phosphodiesterase with transducin

1989 • 50 citations

Domain mapping of the retinal cyclic GMP phosphodiesterase γ-subunit. Function of the domains encoded by the three exons of the γ-subunit gene

1992 • 50 citations

Modulation of retinal transducin and phosphodiesterase activities by synthetic peptides of the phosphodiesterase γ‐subunit

1987 • 26 citations

Modulation of the GTPase Activity of Transducin. Kinetic Studies of Reconstituted Systems

1994 • 21 citations

Probing G-protein function

1994 • 3 citations