Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Rhodopsin content in the outer segment membranes of bovine and frog retinal rods

1974 • 730 citations

Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments.

1979 • 448 citations

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

1982 • 336 citations

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1992 • 324 citations

Molecular mechanism of visual transduction

1989 • 312 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

cGMP phosphodiesterase of retinal rods is regulated by two inhibitory subunits.

1988 • 246 citations

Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence.

1985 • 202 citations

GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence.

1985 • 169 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 167 citations

Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its γ subunit and transducin

1986 • 151 citations

Molecular Properties of the cGMP Cascade of Vertebrate Photoreceptors

1987 • 137 citations

[72] Real time assay of rod disk membrane cGMP phosphodiesterase and its controller enzymes

1982 • 125 citations

Synthesis of 3,6-disulfonated 4-aminonaphthalimides

1981 • 124 citations

Activation mechanism of rod outer segment cyclic GMP phosphodiesterase. Release of inhibitor by the GTP/GTP-binding protein.

1983 • 117 citations

G protein-effector coupling: binding of rod phosphodiesterase inhibitory subunit to transducin

1989 • 104 citations

Activation of retinal rod cyclic GMP‐phosphodiesterase by transducin: Characterization of the complex formed by phosphodiesterase inhibitor and transducin α‐subunit

1986 • 102 citations

A site on rod G protein alpha subunit that mediates effector activation

1992 • 101 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 94 citations

Structural analysis of rod GTP-binding protein, Gt. Limited proteolytic digestion pattern of Gt with four proteases defines monoclonal antibody epitope

1991 • 93 citations

Activation mechanism of retinal rod cyclic GMP phosphodiesterase probed by fluorescein-labeled inhibitory subunit

1990 • 86 citations

Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase

1992 • 79 citations

Active sites of the cyclic GMP phosphodiesterase γ‐subunit of retinal rod outer segments

1988 • 69 citations

Activated cGMP phosphodiesterase of retinal rods. A complex with transducin alpha subunit.

1992 • 64 citations

Expression in bacteria of functional inhibitory subunit of retinal rod cGMP phosphodiesterase.

1989 • 62 citations

The regulation of the cyclic GMP phosphodiesterase by the GDP-bound form of the α subunit of transducin

1989 • 54 citations

Interaction of the γ-subunit of retinal rod outer segment phosphodiesterase with transducin

1989 • 50 citations

Domain mapping of the retinal cyclic GMP phosphodiesterase γ-subunit. Function of the domains encoded by the three exons of the γ-subunit gene

1992 • 50 citations

Resolution of transducin subunits by chromatography on blue sepharose

1987 • 46 citations

[63] Purification of rod outer segment GTP-Binding protein subunits and cgmp phosphodiesterase by single-step column chromatography

1988 • 42 citations

A novel magnesium‐dependent mechanism for the activation of transducin by fluoride

1990 • 41 citations

Fluorescent labeling of signal-transducing G-proteins. Pertussis toxin-catalyzed etheno-ADP ribosylation of transducin.

1988 • 26 citations

Resonance energy transfer as a direct monitor of GTP-binding protein-effector interactions: activated .alpha.-transducin binding to the cGMP phosphodiesterase in the bovine phototransduction cascade

1991 • 20 citations