Nitric oxide and mitochondrial respiration

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

1997 • 1,855 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Oxygen activation and the conservation of energy in cell respiration

1992 • 1,121 citations

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

1994 • 1,026 citations

Persistent inhibition of cell respiration by nitric oxide: Crucial role ofS-nitrosylation of mitochondrial complex I and protective action of glutathione

1998 • 825 citations

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

1996 • 771 citations

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

1996 • 726 citations

Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport

1996 • 719 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Control of respiration and ATP synthesis in mammalian mitochondria and cells

1992 • 598 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Accelerated reaction of nitric oxide with O ₂ within the hydrophobic interior of biological membranes

1998 • 590 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

Nitric oxide synthase activity in mitochondria

1997 • 576 citations

Production of Nitric Oxide by Mitochondria

1998 • 573 citations

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

1995 • 540 citations

Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation

1997 • 530 citations

Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases

1997 • 525 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Nitric oxide neurotoxicity

1996 • 496 citations

Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture

1995 • 493 citations

Cytochrome c in the apoptotic and antioxidant cascades

1998 • 491 citations

Control of apoptosis by the cellular ATP level

1996 • 465 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes

1994 • 407 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

Reactions of cytochrome oxidase with oxygen and carbon monoxide

1963 • 382 citations

Endothelial-Type Nitric Oxide Synthase (ec-NOS) in Skeletal Muscle Fibers: Mitochondrial Relationships

1995 • 379 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Purification and Characterization of a Nitric-oxide Synthase from Rat Liver Mitochondria

1998 • 329 citations

Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension

1994 • 324 citations

Role of nitric oxide in the regulation of oxygen consumption in conscious dogs.

1994 • 320 citations

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

1996 • 320 citations

Spectral and Kinetic Studies on the Activation of Soluble Guanylate Cyclase by Nitric Oxide

1996 • 308 citations

Inactivation of Glutathione Peroxidase by Nitric Oxide

1995 • 304 citations

Control of mitochondrial and cellular respiration by oxygen

1995 • 303 citations

On the mechanism by which vascular endothelial cells regulate their oxygen consumption

1999 • 300 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

Reversible Binding and Inhibition of Catalase by Nitric Oxide

1995 • 277 citations

Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells.

1992 • 276 citations

Nitric Oxide

1995 • 266 citations

Intracellular diffusion gradients of O2 and ATP

1986 • 261 citations

Role of Poly-ADP Ribosyltransferase Activation in the Vascular Contractile and Energetic Failure Elicited by Exogenous and Endogenous Nitric Oxide and Peroxynitrite

1996 • 254 citations

Nitric oxide inhibits the cytochrome oxidase but not the alternative oxidase of plant mitochondria

1996 • 248 citations

Mitochondrial Nitric Oxide Synthase: A Ubiquitous Regulator of Oxidative Phosphorylation?

1996 • 244 citations

Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide

1996 • 243 citations

Cytochrome oxidase evolved by tinkering with denitrification enzymes

1994 • 241 citations

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition

1997 • 238 citations

Role of Endothelium-Derived Nitric Oxide in the Modulation of Canine Myocardial Mitochondrial Respiration In Vitro

1996 • 233 citations

Reactions of nitric oxide with cytochrome c oxidase

1980 • 232 citations

Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis

1996 • 224 citations

Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism

1998 • 221 citations

Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger

1996 • 220 citations

Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro

1997 • 216 citations

The Cytotoxicity of Nitroxyl: Possible Implications for the Pathophysiological Role of NO

1998 • 212 citations

Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration

1995 • 207 citations

Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration

1995 • 204 citations

Immunocytochemical Evidence for a Mitochondrially Located Nitric Oxide Synthase in Brain and Liver

1995 • 204 citations

Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve.

1996 • 204 citations

Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite

1998 • 203 citations

Role of the Mitochondrial Permeability Transition Pore in Apoptosis

1997 • 196 citations

Nitric oxide regulates oxygen uptake and hydrogen peroxide release by the isolated beating rat heart

1998 • 192 citations

Kinetics of Cytochrome C2+ Oxidation by Peroxynitrite: Implications for Superoxide Measurements in Nitric Oxide-Producing Biological-Systems

1995 • 188 citations

ATP-Sensitive K ⁺ Channels, Adenosine, and Nitric Oxide–Mediated Mechanisms Account for Coronary Vasodilation During Exercise

1998 • 188 citations

Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration.

1980 • 186 citations

IFN-γ-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-Arginine-derived nitric oxide and non-heme iron proteins

1990 • 185 citations

Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition

1997 • 179 citations

Oxygen-Dependent Regulation of Mitochondrial Energy Metabolism by Nitric Oxide

1995 • 156 citations

Vicious Cycle Involving Na⁺Channels, Glutamate Release, and NMDA Receptors Mediates Delayed Neurodegeneration through Nitric Oxide Formation

1996 • 154 citations

Rapid and irreversible inhibition of creatine kinase by peroxynitrite

1998 • 152 citations

Inhibition of creatine kinase by S‐nitrosoglutathione

1996 • 145 citations

Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A

1994 • 143 citations

On the Mechanism of Inhibition of Cytochrome c Oxidase by Nitric Oxide

1996 • 142 citations

Peroxynitrite Formed by Simultaneous Nitric Oxide and Superoxide Generation Causes Cyclosporin‐A‐Sensitive Mitochondrial Calcium Efflux and Depolarisation

1995 • 140 citations

Interplay between NO and [Fe-S] Clusters: Relevance to Biological Systems

1997 • 128 citations

Peroxynitrite Inactivates Thiol-Containing Enzymes of Trypanosoma cruzi Energetic Metabolism and Inhibits Cell Respiration

1994 • 126 citations

Differential Effects of Nonselective Nitric Oxide Synthase (NOS) and Selective Inducible NOS Inhibition on Hepatic Necrosis, Apoptosis, ICAM-1 Expression, and Neutrophil Accumulation during Endotoxemia

1997 • 126 citations

Canine hindlimb blood flow and O2 uptake after inhibition of EDRF/NO synthesis

1994 • 125 citations

Kinetics of the inhibition of mitochondrial respiration by NO

1997 • 125 citations

Studies of the primary oxygen intermediate in the reaction of fully reduced cytochrome oxidase.

1991 • 122 citations

Peroxynitrite and Brain Mitochondria: Evidence for Increased Proton Leak

1998 • 121 citations

Ca2+-Independent Permeabilization of the Inner Mitochondrial Membrane by Peroxynitrite Is Mediated by Membrane Protein Thiol Cross-Linking and Lipid Peroxidation

1997 • 121 citations

Role of Nitric Oxide in the Control of Renal Oxygen Consumption and the Regulation of Chemical Work in the Kidney

1998 • 118 citations

Reaction of Nitric Oxide with Hæmoglobin and Methæmoglobin

1937 • 114 citations

Modulation of the Mitochondrial Permeability Transition by Nitric Oxide

1997 • 112 citations

Structure of cytochrome a3-Cua3 couple in cytochrome c oxidase as revealed by nitric oxide binding studies.

1979 • 112 citations

Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: Implications for inflammatory, neurodegenerative and ischaemic pathologies

1997 • 109 citations

Endogenous Peroxynitrite Is Involved in the Inhibition of Mitochondrial Respiration in Immuno-Stimulated J774.2 Macrophages

1995 • 109 citations

A Common Mechanism for the Interaction of Nitric Oxide with the Oxidized Binuclear Centre and Oxygen Intermediates of Cytochromec Oxidase

1998 • 105 citations

Nitric oxide ejects electrons from the binuclear centre of cytochrome c oxidase by reacting with oxidised copper: a general mechanism for the interaction of copper proteins with nitric oxide?

1997 • 104 citations

Nitric oxide formed by nitrite reductase of Paracoccus denitrificans is sufficiently stable to inhibit cytochrome oxidase activity and is reduced by its reductase under aerobic conditions

1990 • 99 citations

Nitric Oxide (NO) in Apoptotic versus Necrotic RAW 264.7 Macrophage Cell Death: The Role of NO-Donor Exposure, NAD+Content, and p53 Accumulation

1996 • 98 citations

Reactive Oxygen and Nitrogen Species Regulate Mitochondrial Ca2+ Homeostasis and Respiration

1997 • 98 citations

Untitled

1997 • 94 citations

Nitric-Oxide Kills Hepatocytes by Mobilizing Mitochondrial Calcium

1994 • 94 citations

Evidence for altered sensitivity of the nitric oxide/cGMP signalling cascade in insulin-resistant skeletal muscle

1998 • 94 citations

A Mechanistic Analysis of Nitric Oxide-Induced Cellular Toxicity

1997 • 90 citations

Mitochondrial iron loss from leukemia cells injured by macrophages. A possible mechanism for electron transport chain defects.

1988 • 85 citations

The Effects of Nitric Oxide on Electron Transport Complexes

1996 • 85 citations

Biochemical and biophysical studies on cytochrome aa3 III. The EPR spectrum of NO-ferrocytochrome a3

1971 • 85 citations

Nitric Oxide Causes Glutamate Release from Brain Synaptosomes

1998 • 84 citations

Nitric Oxide (Nitrogen Monoxide, No) Stimulates Insulin Secretion by Inducing Calcium Release from Mitochondria

1995 • 83 citations

Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite

1996 • 82 citations

REACTIONS OF CYTOCHROME OXIDASE

1955 • 81 citations

Cytokine-Stimulated Nitric Oxide Production Inhibits Mitochondrial Activity in Cardiac Myocytes

1995 • 80 citations

Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells

1996 • 72 citations

Cytochrome c Oxidase Catalysis of the Reduction of Nitric Oxide to Nitrous Oxide

1995 • 72 citations

Peroxynitrite Stimulates the Pyridine Nucleotide-Linked Ca²⁺ Release from Intact Rat Liver Mitochondria

1996 • 72 citations

Cytochrome c Oxidase Does Not Catalyze the Anaerobic Reduction of NO

1998 • 68 citations

Fuel oxidation in skeletal muscle is increased by nitric oxide/cGMP – evidence for involvement of cGMP‐dependent protein kinase

1998 • 62 citations

EFFECT OF INCREASED MYOCARDIAL CYCLIC GMP INDUCED BY CYCLIC GMP‐PHOSPHODIESTERASE INHIBITION ON OXYGEN CONSUMPTION AND SUPPLY OF RABBIT HEARTS

1994 • 60 citations

Formation of paramagnetic mononuclear iron nitrosyl complexes from diamagnetic di- and tetranuclear iron-sulphur nitrosyls: characterisation by EPR spectroscopy and study of thiolate and nitrosyl ligand exchange reactions

1985 • 60 citations

Halothane prevents MK-801 neurotoxicity in the rat cingulate cortex

1995 • 60 citations

Pretreatment of Astrocytes with Interferon‐α/β Prevents Neuronal Mitochondrial Respiratory Chain Damage

1998 • 59 citations

The source of non-heme iron that binds nitric oxide in cultivated macrophages

1992 • 55 citations

Direct measurement of the accumulation and mitochondrial conversion of nitric oxide within Chinese hamster ovary cells using an intracellular electron paramagnetic resonance technique

1995 • 54 citations

Trolox protects mitochondrial complex IV from nitric oxide-mediated damage in astrocytes

1994 • 54 citations

Thiols Protect the Inhibition of Myocardial Aconitase by Peroxynitrite

1998 • 53 citations

Infrared Characterization of Nitric Oxide Bonding to Bovine Heart Cytochrome c Oxidase and Myoglobin

1994 • 51 citations

Ammonia permeability of erythrocyte membrane studied by 14N and 15N saturation transfer NMR spectroscopy

1995 • 50 citations

The Deactivation of Soluble Guanylyl Cyclase by Redox-Active Agents,

1998 • 43 citations

An EPR study of the photodissociation reactions of oxidised cytochrome c oxidase-nitric oxide complexes

1983 • 43 citations

Oxygen-dependent regulation of energy metabolism in ascites tumor cells by nitric oxide.

1996 • 41 citations

Regulation of energy metabolism by interleukin-1 β, but not by interleukin-6, is mediated by nitric oxide in primary cultured rat hepatocytes

1996 • 39 citations

Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo

1996 • 38 citations

Interferon‐γ/lipolysaccharide‐treated mouse embryonic fibroblasts are killed by a glycolysis/<scp>l</scp>‐arginine‐dependent process accompanied by depression of mitochondrial respiration

1991 • 36 citations

Endogenously produced peroxynitrite induces the oxidation of mitochondrial and nuclear proteins in immunostimulated macrophages

1997 • 35 citations

EPR studies of¹⁵NO‐ferrocytochromea₃ in cytochromec oxidase

1979 • 35 citations

Role of glutathione and nitric oxide in the energy metabolism of rat liver mitochondria

1997 • 34 citations

Electron paramagnetic resonance spectroscopic investigation of the inhibition of the phosphoroclastic system of Clostridium sporogenes by nitrite

1990 • 32 citations

Effects of NO‐Generating Compounds on Synaptosomal Energy Metabolism

1995 • 29 citations

The Interactions between Nitric Oxide and Brain Nerve Terminals as Studied by Electron Paramagnetic Resonance

1995 • 27 citations

Investigations into the Mechanism of Action of a Novel Nitric Oxide Generator on Cellular Respiration

1996 • 20 citations

Low toxicity of nitric oxide against endothelial cells under physiological oxygen partial pressures

1998 • 18 citations

Exogenous nitric oxide reduces oxygen consumption of isolated ventricular myocytes less than other forms of guanylate cyclase stimulation

1998 • 17 citations

Age-Related Impairment in Striatal Muscarinic Cholinergic Signal Transduction Is Associated with Reduced Membrane Bilayer Width Measured by Small Angle X-Ray Diffraction

1995 • 16 citations

Role of nitric oxide and superoxide anion in leukotoxin-, 9,10-epoxy-12-octadecenoate-induced mitochondrial dysfunction

1996 • 16 citations