Smad Transcriptional Corepressors in TGFβ Family Signaling

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Retinoic Acid Embryopathy

1985 • 1,921 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1999 • 833 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

1994 • 769 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals

1997 • 612 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

1992 • 495 citations

Smads and early developmental signaling by the TGFβ superfamily

1998 • 485 citations

SMADs: mediators and regulators of TGF-β signaling

1998 • 476 citations

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1999 • 471 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

Interaction and Functional Cooperation of PEBP2/CBF with Smads

1999 • 449 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination

2000 • 393 citations

c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads

1999 • 380 citations

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

1998 • 369 citations

Transforming growth factor beta and cell cycle regulation.

1995 • 368 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Determinants of specificity in TGF-β signal transduction

1998 • 364 citations

Physical and Functional Interaction of SMADs and p300/CBP

1998 • 351 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

Mechanism of TGFβ receptor inhibition by FKBP12

1997 • 342 citations

Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators

1998 • 320 citations

Smad5 and DPC4 Are Key Molecules in Mediating BMP-2-induced Osteoblastic Differentiation of the Pluripotent Mesenchymal Precursor Cell Line C2C12

1998 • 319 citations

A Novel Homeobox Protein Which Recognizes a TGT Core and Functionally Interferes with a Retinoid-responsive Motif

1995 • 305 citations

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene

1998 • 288 citations

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

1999 • 277 citations

Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

1999 • 265 citations

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors

1998 • 265 citations

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling

1999 • 252 citations

Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4

1999 • 249 citations

Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer

1998 • 230 citations

Multiple Modes of Repression by the Smad Transcriptional Corepressor TGIF

1999 • 204 citations

The ski oncogene induces muscle differentiation in quail embryo cells

1989 • 188 citations

Smad1 Interacts with Homeobox DNA-binding Proteins in Bone Morphogenetic Protein Signaling

1999 • 187 citations

Holoprosencephaly: A paradigm for the complex genetics of brain development

1998 • 176 citations

Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogene

1986 • 173 citations

Isolation of human cDNA clones ofskiand the ski-related gene,sno

1989 • 169 citations

Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway

1997 • 168 citations

Smad8 mediates the signaling of the receptor serine kinase

1997 • 155 citations

Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: Interactions of promoter DNA, transcription factor μE3, and Smad proteins

1999 • 155 citations

Holoprosencephaly: from Homer to Hedgehog

1998 • 145 citations

Molecular Mechanisms of Holoprosencephaly

1999 • 141 citations

Teratogenicity of low doses of all‐trans retinoic acid in presomite mouse embryos

1995 • 132 citations

FAST-2 Is a Mammalian Winged-Helix Protein Which Mediates Transforming Growth Factor β Signals

1999 • 88 citations

Viral Ski Inhibits Retinoblastoma Protein (Rb)-mediated Transcriptional Repression in a Dominant Negative Fashion

1999 • 87 citations

Activation of the c-ski oncogene by overexpression

1991 • 85 citations

Human CPR (Cell Cycle Progression Restoration) Genes Impart a Far– Phenotype on Yeast Cells

1997 • 75 citations

The Evi-1 proto-oncogene encodes a transcriptional repressor activity associated with transformation

1997 • 72 citations

Proto-oncogene Sno expression, alternative isoforms and immediate early serum response

1997 • 62 citations

Requirement of protein co-factor for the DNA-binding function of the human ski proto-oncogene product

1990 • 61 citations

Transforming Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and in vivo recombinations

1986 • 61 citations

Snol, a novel alternatively spliced isoform of the ski protooncogene homolog, sno

1993 • 60 citations

The v-ski Oncogene Encodes a Truncated Set of c-ski Coding Exons with Limited Sequence and Structural Relatedness to v-myc

1989 • 59 citations

Transcriptional Repression by v-Ski and c-Ski Mediated by a Specific DNA Binding Site

1998 • 54 citations

A carboxyl-terminal region of the ski oncoprotein mediates homodimerization as well as heterodimerization with the related protein SnoN.

1994 • 50 citations

Isolation and characterization of three distinct cDNAs for the chicken c-ski gene.

1989 • 50 citations

Expression of a novel murine homeobox gene in the developing cerebellar external granular layer during its proliferation

1996 • 46 citations

Identification of a core functional and structural domain of the v-Ski oncoprotein responsible for both transformation and myogenesis

1997 • 44 citations

Evi-1 ZF1 DNA binding activity and a second distinct transcriptional repressor region are both required for optimal transformation of Rat1 fibroblasts

1998 • 36 citations

TGF‐β regulation of nuclear proto‐oncogenes and TGF‐β gene expression in normal human osteoblast‐like cells

1995 • 31 citations

Association of specific DNA binding and transcriptional repression with the transforming and myogenic activities of c-Ski.

1999 • 21 citations

Immediate Early Gene Responses of NIH 3T3 Fibroblasts and NMuMG Epithelial Cells to TGFβ-1

1991 • 21 citations

Zinc Fingers 1–7 of EVI1 Fail to Bind to the GATA Motif by Itself but Require the Core Site GACAAGATA for Binding

1996 • 19 citations

Isolation and characterization of the chicken homeodomain protein AKR

1995 • 11 citations