Enoyl-Coenzyme A Hydratase-Catalyzed Exchange of the .alpha.-Protons of Coenzyme A Thiol Esters: A Model for an Enolized Intermediate in the Enzyme-Catalyzed Elimination?

When is an intermediate not an intermediate? Enforced mechanisms of general acid-base, catalyzed, carbocation, carbanion, and ligand exchange reaction

1980 • 383 citations

[137] Preparation and assay of acyl coenzyme A and other thiol esters; use of hydroxylamine

1957 • 354 citations

Understanding the rates of certain enzyme-catalyzed reactions: Proton abstraction from carbon acids, acyl transfer reactions, and displacement reactions of phosphodiesters

1993 • 352 citations

Understanding enzyme-catalyzed proton abstraction from carbon acids: details of stepwise mechanisms for .beta.-elimination reactions

1992 • 177 citations

A New Method for the Preparation of Acyl-CoA Thioesters1

1981 • 169 citations

Electrophilic catalysis can explain the unexpected acidity of carbon acids in enzyme-catalyzed reactions

1991 • 166 citations

Kinetic and ultraviolet spectroscopic studies of active-site mutants of .DELTA.5-3-ketosteroid isomerase

1989 • 122 citations

[18] Bovine liver crotonase (enoyl coenzyme A hydratase)

1975 • 114 citations

Generation and stability of a simple thiol ester enolate in aqueous solution

1992 • 94 citations

Mitochondrial metabolism of valproic acid

1991 • 92 citations

Substrate Stereochemistry of the Enoyl‐CoA Hydratase Reaction

1975 • 86 citations

Use of isotope effects to deduce the chemical mechanism of fumarase

1980 • 85 citations

Molecular cloning and sequence analysis of the cDNA for rat mitochondrial enoyl‐CoA hydratase

1989 • 76 citations

Crotonase-catalyzed .beta.-elimination is concerted: a double isotope effect study

1991 • 72 citations

Mechanism of the reaction catalyzed by mandelate racemase. 3. Asymmetry in reactions catalyzed by the H297N mutant

1991 • 67 citations

Mechanism of action of enolase: effect of the .beta.-hydroxy group on the rate of dissociation of the .alpha.-carbon-hydrogen bond

1980 • 53 citations

Investigation of the solution conformation of coenzyme A and its derivatives by hydrogen-1 and phosphorus-31 fast Fourier transform nuclear magnetic resonance spectroscopy

1975 • 49 citations

Stereochemistry of the oxidation at the α carbon of butyryl‐CoA and of the enzymic hydrogen exchange

1970 • 41 citations

Site-directed mutagenesis of putative active-site amino acid residues of 3,2-trans-enoyl-CoA isomerase, conserved within the low-homology isomerase/hydratase enzyme family

1993 • 39 citations

Electronic Rearrangement Induced by Substrate Analog Binding to the Enoyl-CoA Hydratase Active Site: Evidence for Substrate Activation

1994 • 37 citations

Isotope effects on the crotonase reaction

1989 • 33 citations

Active-site-directed inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by 3-chloropropionyl coenzyme A

1985 • 32 citations

Citrate synthase stabilizes the enethiolate of acetyldithio-coenzyme A

1989 • 30 citations

Borderline between E1cB and E2 mechanisms. Elimination of hydrogen chloride from fluorene derivatives

1988 • 29 citations

Primary and Secondary Kinetic Isotope Effects as Probes of the Mechanism of Yeast Enolase

1994 • 28 citations

Bovine Liver Crotonase

1973 • 27 citations

Hydride transfer catalyzed by lactate dehydrogenase displays absolute stereospecificity at C4 of the nicotinamide ring

1988 • 24 citations

Lactate dehydrogenase displays absolute stereospecificity in the transfer of the prochiral hydrogen of NADH

1989 • 17 citations

Acetyl coenzyme A synthetase catalyzed reactions of coenzyme A with α,β-unsaturated carboxylic acids

1988 • 12 citations

Elimination and addition reactions. Part 31. Polar effects on the ionisation of sulphones, nitriles, and ketones

1977 • 9 citations

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