Use of isotope effects to deduce the chemical mechanism of fumarase

Statistical estimations in enzyme kinetics

1961 • 3,586 citations

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

Steady-state analysis of kinetic isotope effects in enzymic reactions

1975 • 376 citations

Determining the Chemical Mechanisms of Enzyme‐Catalyzed Reactions by Kinetic Studies

1977 • 340 citations

Internal Rotation and Infrared Spectra of Formic Acid Monomer and Normal Coordinate Treatment of Out-of-Plane Vibrations of Monomer, Dimer, and Polymer

1959 • 184 citations

Stereoselective preparation of deuterated reduced nicotinamide adenine nucleotides and substrates by enzymatic synthesis

1979 • 116 citations

[5] Measurement of isotope effects by the equilibrium perturbation technique

1980 • 115 citations

3-Carbanionic substrate analogues bind very tightly to fumarase and aspartase.

1980 • 114 citations

Heavy-atom isotope effects on the alkaline hydrolysis and hydrazinolysis of methyl benzoate

1979 • 111 citations

Calculation of H/D carbon-12/carbon-13, and carbon-12/carbon-14 fractionation factors from valence force fields derived for a series of simple organic molecules

1972 • 95 citations

Equilibrium perturbation by isotope substitution

1975 • 85 citations

The Substrate Specificity of Fumarase

1968 • 76 citations

Nitro analogs of citrate and isocitrate as transition-state analogs for aconitase

1980 • 72 citations

Fluoronitroaliphatics. I. The Effect of α Fluorine on the Acidities of Substituted Nitromethanes¹

1966 • 60 citations

Initial and Equilibrium 18O, 14C, 3H, and 2H Exchange Rates as Probes of the Fumarase Reaction Mechanism

1969 • 60 citations

The Temperature Dependence of the Steady State Kinetic Parameters of the Fumarase Reaction

1963 • 56 citations

Experimental Determination of the Disproportionation of Hydrogen Isotopes in Water

1966 • 50 citations

Kinetic isotope effects for reactions of methyl formate-methoxyl-18O

1973 • 44 citations

CONCERNING THE STEREOSPECIFICITY OF THE FUMARASE REACTION AND THE DEMONSTRATION OF A NEW INTERMEDIATE¹

1955 • 40 citations

Studies of the Enzyme Fumarase. VI.¹ Study of the Incorporation of Deuterium into L-Malate during the Reaction in Deuterium Oxide^2,3

1957 • 37 citations

Proton Magnetic Resonance Spectra of Malic Acid and its Salts in Deuterium Oxide^1,2

1959 • 36 citations

The pH Dependence of the Competitive Inhibition of Fumarase^1,2

1960 • 33 citations

Fumarase activity in D2O

1960 • 21 citations

LIV.—Chlorofumaric and chloromaleic acids and the magnetic rotatory power of some of their derivatives

1888 • 20 citations

Fluorofumarate—A substrate for fumarate hydratase

1968 • 18 citations

Substrates for fumarate hydratase

1969 • 17 citations

Rates of proton abstraction from 4-nitrobenzyl halides

1979 • 3 citations