Crotonase-catalyzed .beta.-elimination is concerted: a double isotope effect study

[29] Solvent isotope effects on enzyme systems

1982 • 394 citations

Enzymes of fatty acid metabolism

1953 • 365 citations

Partition analysis and concept of net rate constants as tools in enzyme kinetics

1975 • 323 citations

Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose 6-phosphate dehydrogenase

1982 • 184 citations

Purification and mechanism of action of proline racemase

1968 • 173 citations

Use of Isotope Effects to Elucidate Enzyme Mechanism

1982 • 167 citations

Use of nitrogen-15 and deuterium isotope effects to determine the chemical mechanism of phenylalanine ammonia-lyase

1985 • 158 citations

Reaction-coordinate tunneling in hydride-transfer reactions

1983 • 133 citations

Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 2. Formate dehydrogenase

1984 • 118 citations

Purification and properties of a pig heart thiolase with broad chain length specificity and comparison of thiolases from pig heart and Escherichia coli.

1978 • 115 citations

[5] Measurement of isotope effects by the equilibrium perturbation technique

1980 • 115 citations

Calculations of isotope effects in elimination reactions. New experimental criteria for tunneling in slow proton transfers

1985 • 114 citations

[18] Bovine liver crotonase (enoyl coenzyme A hydratase)

1975 • 114 citations

Enoyl Coenzyme A Hydratase (Crotonase)

1972 • 112 citations

Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase

1981 • 111 citations

Solvent isotope effect in H2O-D2O mixtures

1964 • 109 citations

ENZYMES OF FATTY ACID METABOLISM

1956 • 105 citations

Substrate Stereochemistry of the Enoyl‐CoA Hydratase Reaction

1975 • 86 citations

Use of isotope effects to deduce the chemical mechanism of fumarase

1980 • 85 citations

General base catalysis, structure-reactivity interactions, and merging of mechanisms for elimination reactions of (2-arylethyl)quinuclidinium ions

1982 • 83 citations

The use of isotope effects in the detailed analysis of catalytic mechanisms of enzymes

1987 • 72 citations

Studies on the reaction mechanism of general acyl‐CoA dehydrogenase

1986 • 66 citations

Use of multiple isotope effects to study the mechanism of 6-phosphogluconate dehydrogenase

1984 • 63 citations

Anomalous equilibrium and kinetic .alpha.-deuterium secondary isotope effects accompanying hydride transfer from reduced nicotinamide adenine dinucleotide

1980 • 59 citations

Mechanism of action of enolase: effect of the .beta.-hydroxy group on the rate of dissociation of the .alpha.-carbon-hydrogen bond

1980 • 53 citations

Double isotope fractionation: test for concertedness and for transition-state dominance

1983 • 45 citations

Kinetic mechanism and location of rate-determining steps for aspartase from Hafnia alvei

1984 • 43 citations

Malate synthase: proof of a stepwise Claisen condensation using the double-isotope fractionation test

1988 • 40 citations

Theoretical studies on E2 elimination reactions. Evidence that syn elimination is accompanied by inversion of configuration at the carbanionic center

1979 • 39 citations

The Subunit Structure of Crotonase

1969 • 38 citations

Energetics of proline racemase: double fractionation experiment, a test for concertedness and for transition-state dominance

1986 • 37 citations

Mechanism of the chain extension step in the biosynthesis of fatty acids

1988 • 34 citations

The catalytic base of enolase is a sulfhydryl group

1987 • 33 citations

Elimination reactions of .beta.-cyano thioethers: evidence for a carbanion intermediate and a change in rate-limiting step

1988 • 33 citations

Isotope effects on the crotonase reaction

1989 • 33 citations

Energetics of proline racemase: fractionation factors for the essential catalytic groups in the enzyme-substrate complexes

1986 • 30 citations

Citrate synthase stabilizes the enethiolate of acetyldithio-coenzyme A

1989 • 30 citations

Enoyl Coenzyme A Hydratase (Crotonase)

1972 • 29 citations

Bovine Liver Crotonase

1973 • 27 citations

Superiority of very weakly basic amines as catalysts for alpha-proton abstraction via iminium ion formation

1980 • 27 citations

Elimination and addition reactions. Part 32. Discrimination between concerted and stepwise processes in activated elimination reactions

1977 • 24 citations

The reaction of acetyldithio-CoA, a readily enolized analog of acetyl-CoA with thiolase from Zoogloea ramigera.

1990 • 23 citations

Isotope effects on isotope effects. Failure of the rule of the geometric mean as evidence for tunneling

1988 • 23 citations

Isotopic probes of the argininosuccinate lyase reaction

1986 • 18 citations

Mechanisms of elimination reactions. 39. Steric and electronic effects on stereochemistry in eliminations from primary alkyltrimethylammonium salts

1986 • 16 citations

Kinetics of reversible intramolecular elimination reactions. 1. An apparent E2 elimination of a .beta.-acyloxy ketone

1984 • 11 citations

Base-catalyzed .beta.-elimination reactions in aqueous solution. I. Elimination from .beta.-acetoxy ketones

1967 • 10 citations

Base-catalyzed .beta.-elimination reactions in aqueous solution. III. Elimination from tert-butyl 3-acetoxythiol esters

1969 • 7 citations

The E2C mechanism of elimination reactions. 9. Secondary deuterium isotope effects on rates of bimolecular reactions in alicyclic systems

1976 • 3 citations