Genetic Polymorphisms in the ABCB1 Gene and the Effects of Fentanyl in Koreans

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Bispectral Analysis Measures Sedation and Memory Effects of Propofol, Midazolam, Isoflurane, and Alfentanil in Healthy Volunteers

1997 • 1,292 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

2004 • 900 citations

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects

2001 • 757 citations

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 • 675 citations

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 573 citations

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene.

2001 • 538 citations

Intravenous fentanyl kinetics

1980 • 506 citations

Increased drug delivery to the brain by P-glycoprotein inhibition

2000 • 422 citations

Clinical Pharmacokinetics of Fentanyl and its Newer Derivatives

1983 • 375 citations

Electroencephalogram Bispectral Analysis Predicts the Depth of Midazolam-induced Sedation

1996 • 309 citations

Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations

2002 • 281 citations

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

1997 • 272 citations

Opiate-induced Analgesia Is Increased and Prolonged in Mice Lacking P-glycoprotein

2000 • 270 citations

Environmental and genetic factors associated with morphine response in the postoperative period

2006 • 240 citations

Effects of fentanyl, alfentanil, remifentanil and sufentanil on loss of consciousness and bispectral index during propofol induction of anaesthesia

2001 • 240 citations

Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs

2003 • 226 citations

In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results.

2001 • 226 citations

Variable modulation of opioid brain uptake by P-glycoprotein in mice

2003 • 211 citations

Clinical Aspects of the MDR1 (ABCB1) Gene Polymorphism

2004 • 180 citations

Altered Pharmacokinetics of Vinblastine in Mdr1a P-glycoprotein-Deficient Mice

1996 • 175 citations

Establishment and Characterization of the Transformants Stably-Expressing MDR1 Derived from Various Animal Species in LLC-PK1

2006 • 122 citations

Active transport of fentanyl by the blood-brain barrier.

1999 • 119 citations

A variant 2677A allele of the gene affects fexofenadine disposition

2004 • 112 citations

Bispectral index monitoring for conscious sedation in intervention: better, safer, faster

2004 • 95 citations

Verapamil P-glycoprotein Transport across the Rat Blood-Brain Barrier: Cyclosporine, a Concentration Inhibition Analysis, and Comparison with Human Data

2006 • 90 citations

Quinidine as a Probe for the Role of P‐Glycoprotein in the Intestinal Absorption and Clinical Effects of Fentanyl

2004 • 78 citations

Pharmacokinetics of fentanyl as determined by radioimmunoassay

1978 • 76 citations

Effects of Cyclosporine on Anesthetic Action

1987 • 65 citations

No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects

2003 • 54 citations

Development of a P-Glycoprotein Knockout Model in Rodents to Define Species Differences in its Functional Effect at the Blood–brain Barrier

2006 • 44 citations

Detection of the four sequence variations of MDR1 gene using TaqMan® MGB probe based real-time PCR and haplotype analysis in healthy Japanese subjects

2003 • 42 citations

MDR1 Genetic Polymorphisms and Comparison of MDR1 Haplotype Profiles in Korean and Vietnamese Populations

2005 • 40 citations

A closer look at bispectral index monitoring

2001 • 34 citations

THE BISPECTRAL INDEX (BIS2.0) AS A HYPNOSIS MEASURE

1994 • 7 citations

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