Environmental and genetic factors associated with morphine response in the postoperative period

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction

1998 • 1,055 citations

Identification of functionally variant MDR1 alleles among European Americans and African Americans

2001 • 1,000 citations

Effects of Nonsteroidal Antiinflammatory Drugs on Patient-controlled Analgesia Morphine Side Effects

2005 • 574 citations

The 118 A > G polymorphism in the human µ‐opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

2004 • 370 citations

Age is the best predictor of postoperative morphine requirements

1996 • 309 citations

Association of the Multidrug Resistance-1 Gene Single-Nucleotide Polymorphisms with the Tacrolimus Dose Requirements in Renal Transplant Recipients

2003 • 281 citations

Clinical Pharmacokinetics of Morphine

1991 • 280 citations

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

2005 • 268 citations

Sex- and Age-related Differences in Morphine Requirements for Postoperative Pain Relief

2005 • 260 citations

Genetic Predictors of the Clinical Response to Opioid Analgesics

2004 • 253 citations

EVALUATION OF 3′-AZIDO-3′-DEOXYTHYMIDINE, MORPHINE, AND CODEINE AS PROBE SUBSTRATES FOR UDP-GLUCURONOSYLTRANSFERASE 2B7 (UGT2B7) IN HUMAN LIVER MICROSOMES: SPECIFICITY AND INFLUENCE OF THE UGT2B7^*2 POLYMORPHISM

2003 • 246 citations

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

2000 • 244 citations

Preoperative emotional states in patients with breast cancer and postoperative pain

2002 • 223 citations

Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers

2003 • 222 citations

Interaction of Morphine, Fentanyl, Sufentanil, Alfentanil, and Loperamide with the Efflux Drug Transporter P-glycoprotein

2002 • 209 citations

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

2002 • 208 citations

Stress reduction and analgesia in patients exposed to calming music postoperatively

2005 • 196 citations

A pharmacogenetic study of uridine diphosphate–glucuronosyltransferase 2B7 in patients receiving morphine

2003 • 174 citations

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

2003 • 160 citations

Dose-response relationship between opioid use and adverse effects after ambulatory surgery

2004 • 159 citations

Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients

1999 • 157 citations

P‐glycoprotein‐mediated intestinal and biliary digoxin transport in humans

2003 • 156 citations

Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine

2003 • 154 citations

Clinical response to morphine in cancer patients and genetic variation in candidate genes

2005 • 147 citations

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

2002 • 132 citations

Benzodiazepine mediated antagonism of opioid analgesia

1997 • 129 citations

Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine

2002 • 110 citations

Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers

2003 • 104 citations

Genetic variability and clinical efficacy of morphine

2005 • 101 citations

Ethnicity influences morphine pharmacokinetics and pharmacodynamics

2001 • 90 citations

Increased CNS uptake and enhanced antinociception of morphine‐6‐glucuronide in rats after inhibition of P‐glycoprotein

2002 • 64 citations

Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy

2005 • 44 citations

Interactions between fluoxetine and opiate analgesia for postoperative dental pain

1994 • 40 citations

Opioids Bind to the Amino Acids 84 to 118 of UDP-Glucuronosyltransferase UGT2B7

2003 • 30 citations

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