The INK4a/ARF locus and melanoma

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Germline p16 mutations in familial melanoma

1994 • 1,241 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

2002 • 1,009 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1996 • 944 citations

The p16INK4a/CDKN2A tumor suppressor and its relatives

1998 • 917 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

The Pathogenesis of Melanoma Induced by Ultraviolet Radiation

1999 • 861 citations

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

1994 • 860 citations

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

2001 • 825 citations

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

1996 • 806 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

2001 • 559 citations

The INK4A/ARF locus and its two gene products

1999 • 532 citations

twist is a potential oncogene that inhibits apoptosis

1999 • 511 citations

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27

1999 • 497 citations

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

1998 • 481 citations

p16(MTS-1/CDKN2/INK4a) in Cancer Progression

2001 • 470 citations

Identification of CDK4 as a target of c-MYC

2000 • 457 citations

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

1997 • 405 citations

Neonatal sunburn and melanoma in mice

2001 • 383 citations

Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

1996 • 319 citations

A germline deletion of p14ARF but not CDKN2A in a melanoma-neural system tumour syndrome family

2001 • 271 citations

The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia

2002 • 262 citations

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins

1997 • 206 citations

Sun exposure and melanocytic naevi in young Australian children

1994 • 195 citations

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

2000 • 194 citations

Compilation of somatic mutations of theCDKN2 gene in human cancers: Non-random distribution of base substitutions

1996 • 174 citations

A melanoma-associated germline mutation in exon 1β inactivates p14ARF

2001 • 173 citations

Involvement of Myc Activity in a G₁/S-Promoting Mechanism Parallel to the pRb/E2F Pathway

2000 • 165 citations

Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas

2001 • 165 citations

p16^INK4A Participates in a G₁ Arrest Checkpoint in Response to DNA Damage

1998 • 163 citations

Invasive melanoma in Cdk4-targeted mice

2001 • 161 citations

Mutations of the CDKN2/p16^INK4 gene in Australian melanoma kindreds

1995 • 149 citations

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16^INK4aand p19^ARF, is a candidate for the plasmacytoma susceptibility locus,Pctr1

1998 • 148 citations

Virtually 100% of melanoma cell lines harbor alterations at the DNA level withinCDKN2A, CDKN2B, or one of their downstream targets

1998 • 145 citations

p19 ^Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation

1998 • 137 citations

Cutaneous melanoma and sunburns in childhood in a Southern European population

1992 • 136 citations

Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

2003 • 117 citations

Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity

1997 • 113 citations

The p16INK4a tumour suppressor protein inhibits alpha vbeta 3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alpha vbeta 3 to focal contacts

1999 • 112 citations

Patterns of neuropsychological deficits in children with medulloblastoma according to craniospatial irradiation doses

2000 • 110 citations

Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC)

1998 • 101 citations

A CDKN2 -like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish–swordtail hybrids

1996 • 87 citations

G2 phase cell cycle arrest in human skin following UV irradiation

2001 • 82 citations

Photocarcinogenesis in human adult skin grafts

2002 • 76 citations

p16INK4 mediates contact-inhibition of growth

1999 • 67 citations

Expression of cell cycle regulators in human cutaneous malignant melanoma

1999 • 45 citations

The expression of p16INK4a, the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation

2000 • 43 citations

High energy neutrino astronomy

2002 • 1 citations