Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

A sharper Bonferroni procedure for multiple tests of significance

1988 • 4,545 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Apoptosis in the Failing Human Heart

1997 • 1,690 citations

Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy

1993 • 1,218 citations

Adrenergic effects on the biology of the adult mammalian cardiocyte.

1992 • 873 citations

Norepinephrine Stimulates Apoptosis in Adult Rat Ventricular Myocytes by Activation of the β-Adrenergic Pathway

1998 • 690 citations

Double-Blind, Placebo-Controlled Study of the Effects of Carvedilol in Patients With Moderate to Severe Heart Failure

1996 • 626 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.

1994 • 560 citations

Opposing Effects of β ₁ - and β ₂ -Adrenergic Receptors on Cardiac Myocyte Apoptosis

1999 • 557 citations

Angiotensin II Induces Apoptosis of Adult Ventricular MyocytesIn Vitro

1997 • 413 citations

Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.

1996 • 360 citations

Programmed Myocyte Cell Death Affects the Viable Myocardium after Infarction in Rats

1996 • 340 citations

Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure.

1996 • 335 citations

Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: A randomized, double-blind, placebo-controlled study

1994 • 318 citations

Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.

1993 • 292 citations

A canine model of chronic heart failure produced by multiple sequential coronary microembolizations

1991 • 291 citations

Bcl-2 expression prevents activation of the ICE protease cascade.

1996 • 254 citations

Possible Involvement of Stress-Activated Protein Kinase Signaling Pathway and Fas Receptor Expression in Prevention of Ischemia/Reperfusion-Induced Cardiomyocyte Apoptosis by Carvedilol

1998 • 236 citations

Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction.

1994 • 207 citations

Progression of heart failure: A role for interstitial fibrosis

1995 • 163 citations

Staurosporine-induced Apoptosis in Cardiomyocytes: A Potential Role of Caspase-3

1998 • 162 citations

Co-localization of the Cysteine Protease Caspase-3 with Apoptotic Myocytes afterIn VivoMyocardial Ischemia and Reperfusion in the Rat

1998 • 153 citations

Fast computed tomography detection of coronary calcification in the diagnosis of coronary artery disease. Comparison with angiography in patients < 50 years old.

1994 • 138 citations

Ca2+Mg2+-dependent nuclease: Tissue distribution, relationship to inter-nucleosomal DNA fragmentation and inhibition by Zn2+

1991 • 129 citations

Effects of ACE inhibition on cardiomyocyte apoptosis in dogs with heart failure

1998 • 121 citations

Apoptotic cell death in heart failure

2000 • 113 citations

Elevated DNase I Levels in Human Idiopathic Dilated Cardiomyopathy: an Indicator of Apoptosis ?

1996 • 63 citations

SR Ca(2+)-ATPase activity and expression in ventricular myocardium of dogs with heart failure

1997 • 52 citations

Abnormalities of cardiocytes in regions bordering fibrous scars of dogs with heart failure

1997 • 43 citations

Reduced Sarcoplasmic Reticulum Ca2+-Uptake and Expression of Phospholamban in Left Ventricular Myocardium of Dogs with Heart Failure

1999 • 35 citations

Untitled

1998 • 2 citations