Possible Involvement of Stress-Activated Protein Kinase Signaling Pathway and Fas Receptor Expression in Prevention of Ischemia/Reperfusion-Induced Cardiomyocyte Apoptosis by Carvedilol

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

1996 • 4,580 citations

The Fas Death Factor

1995 • 4,070 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Apoptosis in Myocytes in End-Stage Heart Failure

1996 • 1,446 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Apoptosis in Ischemic and Reperfused Rat Myocardium

1996 • 801 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

Stretch-induced programmed myocyte cell death.

1995 • 647 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.

1994 • 560 citations

Stimulation of the Stress-Activated Mitogen-Activated Protein Kinase Subfamilies in Perfused Heart

1996 • 531 citations

Acute Myocardial Infarction in Humans is Associated with Activation of Programmed Myocyte Cell Death in the Surviving Portion of the Heart

1996 • 515 citations

Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger.

1992 • 489 citations

Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia

1996 • 421 citations

BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy

1996 • 420 citations

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.

1995 • 397 citations

Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

1997 • 374 citations

Expression of bcl-2 Protein, an Inhibitor of Apoptosis, and Bax, an Accelerator of Apoptosis, in Ventricular Myocytes of Human Hearts With Myocardial Infarction

1996 • 367 citations

Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation

1993 • 351 citations

Signal Transduction Pathways in Apoptosis

1996 • 224 citations

Stress-Activated Protein Kinases in Cardiovascular Disease

1996 • 204 citations

2-Methoxyestradiol, an Endogenous Estrogen Metabolite, Induces Apoptosis in Endothelial Cells and Inhibits Angiogenesis: Possible Role for Stress-Activated Protein Kinase Signaling Pathway and Fas Expression

1997 • 193 citations

Hypoxia/Reoxygenation Stimulates Jun Kinase Activity Through Redox Signaling in Cardiac Myocytes

1997 • 179 citations

Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes.

1992 • 129 citations

Myocyte death in heart failure

1996 • 123 citations

Techniques in apoptosis

1996 • 92 citations

Carvedilol, a new beta adrenoreceptor blocker and free radical scavenger, attenuates myocardial ischemia-reperfusion injury in hypercholesterolemic rabbits.

1996 • 80 citations

N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death.

1992 • 78 citations

Protective Effects of Carvedilol, a Vasodilating β-Adrenoceptor Blocker, Against in vivo Low Density Lipoprotein Oxidation in Essential Hypertension

1996 • 72 citations

Post-ischemic apoptotic death of rat neonatal cardiomyocytes.

1995 • 58 citations

Life and Death in the Cardiovascular System

1997 • 52 citations

Signal transduction in myocardial ischaemia*

1994 • 44 citations

Carvedilol update III: Rationale for use in congestive heart failure

1995 • 34 citations

Apoptosis and Congestive Heart Failure

1997 • 33 citations