The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents II: The Mechanism of Action of Ligands Derived From Salicylaldehyde Benzoyl Hydrazone and 2-Hydroxy-1-Naphthylaldehyde Benzoyl Hydrazone

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents

1995 • 343 citations

Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio.

1996 • 257 citations

Effect of Iron Deficiency and Desferrioxamine on DNA Synthesis in Human Cells

1976 • 242 citations

Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators.

1993 • 199 citations

Effects of a single course of deferoxamine in neuroblastoma patients.

1990 • 197 citations

Mobilization of iron from reticulocytes

1979 • 196 citations

Studies in Desferrioxamine and Ferrioxamine Metabolism in Normal and Iron‐Loaded Subjects

1979 • 189 citations

Cytotoxic chelators and chelates 1. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone

1982 • 188 citations

In vitro and in vivo effects of deferoxamine in neonatal acute leukemia

1987 • 185 citations

The uptake of iron and transferrin by the human malignant melanoma cell

1990 • 178 citations

Antineuroblastoma activity of desferoxamine in human cell lines.

1987 • 146 citations

The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell.

1994 • 141 citations

Interleukin‐4 inhibits apoptotic cell death and loss of the bcl‐2 protein in B‐chronic lymphocytic leukaemia cells in vitro

1993 • 140 citations

Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism

1996 • 137 citations

Neuroblastoma sensitivity to growth inhibition by deferrioxamine: evidence for a block in G1 phase of the cell cycle.

1993 • 130 citations

Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture

1992 • 130 citations

Iron chelators induce apoptosis in proliferating cells

1995 • 124 citations

Dopamine-induced programmed cell death in mouse thymocytes

1995 • 120 citations

Deferoxamine inhibition of human neuroblastoma viability and proliferation.

1988 • 108 citations

Induction of apoptosis by iron deprivation in human leukemic CCRF-CEM cells.

1995 • 96 citations

Effective Iron Chelation following Oral Administration of an Isoniazid‐Pyridoxal Hydrazone

1979 • 94 citations

Mode of Action of the Cytostatic Agent ‘ICRF 159’

1970 • 90 citations

Effect of pyridoxal isonicotinoyl hydrazone and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes

1988 • 74 citations

Comparison of activity of deferoxamine with that of oral iron chelators against human neuroblastoma cell lines.

1989 • 71 citations

Pyridoxal isonicotinoyl hydrazone: an effective iron-chelator after oral administration.

1990 • 68 citations

Deferoxamine, Cyclophosphamide, Etoposide, Carboplatin, and Thiotepa (D-CECaT)

1992 • 64 citations

The effect of desferrioxamine on transferrin receptors, the cell cycle and growth rates of human leukaemic cells

1986 • 64 citations

Cell cycle-dependent inhibition of the proliferation of human neural tumor cell lines by iron chelators

1996 • 57 citations

Antileukemic effects of deferoxamine on human myeloid leukemia cell lines.

1989 • 57 citations

Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture

1991 • 57 citations

The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis.

1994 • 54 citations

Effects of agents that inhibit cellular iron incorporation on bladder cancer cell proliferation

1993 • 43 citations

Inhibition of hematopoietic tumor growth by combined treatment with deferoxamine and an IgG monoclonal antibody against the transferrin receptor: evidence for a threshold model of iron deprivation toxicity.

1992 • 39 citations

Pyridoxal isonicotinoyl hydrazone and analogues

1989 • 31 citations

Effects of antigen presentation on superantigen‐induced apoptosis mediated by Fas/Fas ligand interactions in human T cells

1996 • 23 citations

Microbial iron chelator-induced cell cycle synchronization in L1210 cells: potential in combination chemotherapy.

1987 • 22 citations

Deferoxamine and human neuroblastoma and primitive neuroectodermal tumor cell lines.

1992 • 11 citations

In vitro and in vivo effects of deferoxamine in neonatal acute leukemia

1987 • 8 citations