Development of novel aroylhydrazone ligands for iron chelation therapy: 2-Pyridylcarboxaldehyde isonicotinoyl hydrazone analogs

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

1996 • 1,311 citations

Reduction of Ribonucleotides

1979 • 1,170 citations

Iron-Chelating Therapy and the Treatment of Thalassemia

1997 • 1,106 citations

Aconitase and mitochondrial iron–sulphur protein deficiency in Friedreich ataxia

1997 • 975 citations

Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin

1997 • 914 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

1986 • 490 citations

Long-Term Safety and Effectiveness of Iron-Chelation Therapy with Deferiprone for Thalassemia Major

1998 • 430 citations

Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria

1997 • 384 citations

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents

1995 • 343 citations

The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents II: The Mechanism of Action of Ligands Derived From Salicylaldehyde Benzoyl Hydrazone and 2-Hydroxy-1-Naphthylaldehyde Benzoyl Hydrazone

1997 • 205 citations

Effects of a single course of deferoxamine in neuroblastoma patients.

1990 • 197 citations

Mobilization of iron from reticulocytes

1979 • 196 citations

A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents

1979 • 192 citations

Cytotoxic chelators and chelates 1. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone

1982 • 188 citations

The uptake of iron and transferrin by the human malignant melanoma cell

1990 • 178 citations

Iron mobilization from hepatocyte monolayer cultures by chelators: the importance of membrane permeability and the iron-binding constant

1988 • 163 citations

The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents III: The Effect of the Ligands on Molecular Targets Involved in Proliferation

1999 • 163 citations

Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity

1999 • 143 citations

Neuroblastoma sensitivity to growth inhibition by deferrioxamine: evidence for a block in G1 phase of the cell cycle.

1993 • 130 citations

Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture

1992 • 130 citations

Pyridoxal isonicotinoyl hydrazone and its analogs: Potential orally effective iron-chelating agents for the treatment of iron overload disease

1998 • 128 citations

Deferoxamine inhibition of human neuroblastoma viability and proliferation.

1988 • 108 citations

Comparison of two different hybridization systems in northern transfer analysis.

1989 • 103 citations

Effective Iron Chelation following Oral Administration of an Isoniazid‐Pyridoxal Hydrazone

1979 • 94 citations

Cell cycle synchronization and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukemia cell lines.

1992 • 92 citations

Iron utilization in rabbit reticulocytes

1982 • 92 citations

Iron chelators of the pyridoxal isonicotinoyl hydrazone class Part II. Formation constants with iron(III) and iron(II)

1990 • 87 citations

Development of iron chelators to treat iron overload disease and their use as experimental tools to probe intracellular iron metabolism

1998 • 83 citations

Mechanism of in vivo iron chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxal.

1981 • 77 citations

Characterisation of non-transferrin-bound iron (ferric citrate) uptake by rat hepatocytes in culture

1998 • 72 citations

Iron chelators of the pyridoxal isonicotinoyl hydrazone class

1989 • 65 citations

Deferoxamine, Cyclophosphamide, Etoposide, Carboplatin, and Thiotepa (D-CECaT)

1992 • 64 citations

Chelator-mediated iron efflux from reticulocytes

1983 • 62 citations

Potential of iron chelators as effective antiproliferative agents

1997 • 58 citations

Aroylhydrazones as chelating agents: d10-metal complexes of pyridine-2-carbaldehyde salicyloylhydrazone and x-ray structure of the zinc derivative

1984 • 56 citations

The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis.

1994 • 54 citations

Mechanism of antineuroblastoma activity of deferoxamine in vitro.

1988 • 49 citations

Potential of iron chelators as effective antiproliferative agents

1997 • 45 citations

1 Chemical and Biological Properties of Cytotoxic α-(N)-Heterocyclic Carboxaldehyde Thiosemicarbazones

1995 • 38 citations

Verstile ligand behaviour of phenyl 2-pyridyl ketone benzoylhydrazone in palladium(II) complexes

1996 • 35 citations

Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Relationship of the lipophilicity of the apochelator to its ability to mobilise iron from reticulocytes in vitro

1994 • 35 citations

Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo

1995 • 32 citations

Crystal structure and chemical properties of bis(N-picolinylidene-N′-salicyloylhydrazinato)nickel(<scp>II</scp>)

1975 • 27 citations

Biliary Iron Excretion in Rats Following Treatment With Analogs of Pyridoxal Isonicotinoyl Hydrazone

1998 • 27 citations

Effect of hydroxyurea on cellular iron metabolism in human leukemic CCRF-CEM cells: changes in iron uptake and the regulation of transferrin receptor and ferritin gene expression following inhibition of DNA synthesis.

1995 • 22 citations