Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines

The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents II: The Mechanism of Action of Ligands Derived From Salicylaldehyde Benzoyl Hydrazone and 2-Hydroxy-1-Naphthylaldehyde Benzoyl Hydrazone

1997 • 205 citations

Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators.

1993 • 199 citations

The Relationship of Intracellular Iron Chelation to the Inhibition and Regeneration of Human Ribonucleotide Reductase

1996 • 179 citations

The influence of zinc on apoptosis.

1995 • 176 citations

Preneoplastic significance of hepatic iron–free foci in genetic hemochromatosis: A study of 185 patients

1993 • 167 citations

Iron nutrition and tumor growth: decreased tumor growth in iron-deficient mice.

1988 • 148 citations

Cancer risk following primary hemochromatosis: A population‐based cohort study in Denmark

1995 • 140 citations

Neuroblastoma sensitivity to growth inhibition by deferrioxamine: evidence for a block in G1 phase of the cell cycle.

1993 • 130 citations

Iron chelators induce apoptosis in proliferating cells

1995 • 124 citations

Iron Deprivation Inhibits Cyclin-Dependent Kinase Activity and Decreases Cyclin D/CDK4 Protein Levels in Asynchronous MDA-MB-453 Human Breast Cancer Cells

1996 • 102 citations

Effect of dietary iron deficiency or excess on the induction of mammary carcinogenesis by 1-methyl-1-nitrosourea

1991 • 79 citations

Increased risk of hepatocellular carcinoma development in patients with cirrhosis and with high hepatocellular proliferation

1994 • 66 citations

Development of hepatocellular carcinoma associated with increases in DNA synthesis in the surrounding cirrhosis

1992 • 63 citations

O-TRENSOX: A Promising Water-Soluble Iron Chelator (Both FeIII and FeII) Potentially Suitable for Plant Nutrition and Iron Chelation Therapy

1995 • 61 citations

Effects of iron-depletion on cell cycle progression in normal human T lymphocytes: selective inhibition of the appearance of the cyclin A- associated component of the p33cdk2 kinase

1995 • 59 citations

Direct Evidence That Iron Deprivation Induces Apoptosis in Murine Lymphoma 38C13

1997 • 53 citations

Multiple Pathways of Fas-Induced Apoptosis in Primary Culture of Hepatocytes

1996 • 45 citations

Cell cycle gene regulation in reversibly differentiated new human hepatoma cell lines.

1998 • 38 citations

Cell cycle effects of iron depletion on T-47D human breast cancer cells

1985 • 33 citations

Mechanisms of inhibition of mononuclear cell activation by the iron-chelating agent desferrioxamine.

1990 • 31 citations

Iron Mobilisation and Cellular Protection by a New Synthetic Chelator O-Trensox

1998 • 31 citations

2,2'-Bipyridyl-6-carbothioamide and its ferrous complex: their in vitro antitumoral activity related to the inhibition of ribonucleotide reductase R2 subunit.

1993 • 26 citations

Metabolization of iron by plant cells using O-Trensox, a high-affinity abiotic iron-chelating agent

1995 • 26 citations

Deferoxamine arrests in vitro the proliferation of porcine hepatocyte in G1 phase of the cell cycle

1998 • 23 citations

Growth, ribonucleotide reductase and metals in murine leukemic lymphocytes

1991 • 15 citations

The effect of desferrioxamine on the proliferative response of rat lymphocytes stimulated with various mitogens in vitro

1984 • 10 citations

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