Apatite-mediated Actin Dynamics in Resorbing Osteoclasts

Rho GTPases in cell biology

2002 • 4,662 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts

2000 • 715 citations

The cell biology of osteoclast function

2000 • 694 citations

Podosomes: adhesion hot-spots of invasive cells

2003 • 607 citations

Podosomes Display Actin Turnover and Dynamic Self-Organization in Osteoclasts Expressing Actin-Green Fluorescent Protein

2003 • 428 citations

Cbl Associates with Pyk2 and Src to Regulate Src Kinase Activity, αvβ3 Integrin-Mediated Signaling, Cell Adhesion, and Osteoclast Motility

2001 • 365 citations

Src Kinase Activity Is Essential for Osteoclast Function

2004 • 272 citations

Rho-A Is Critical for Osteoclast Podosome Organization, Motility, and Bone Resorption

2000 • 265 citations

Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro

1991 • 245 citations

Osteopontin Deficiency Produces Osteoclast Dysfunction Due to Reduced CD44 Surface Expression

2003 • 229 citations

Dentin Matrix Protein 1 Immobilized on Type I Collagen Fibrils Facilitates Apatite Deposition in Vitro

2004 • 223 citations

Osteoclasts express high levels of pp60c-src in association with intracellular membranes.

1992 • 221 citations

Rous sarcoma virus-transformed fibroblasts and cells of monocytic origin display a peculiar dot-like organization of cytoskeletal proteins involved in microfilament-membrane interactions*1

1987 • 216 citations

Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin

2003 • 175 citations

Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface.

1991 • 172 citations

Podosomes in osteoclast-like cells

2001 • 168 citations

Effect of substrate composition on bone resorption by rabbit osteoclasts

1984 • 142 citations

Osteoclast Ruffled Border Has Distinct Subdomains for Secretion and Degraded Matrix Uptake

2003 • 134 citations

PYK2 Autophosphorylation, but Not Kinase Activity, Is Necessary for Adhesion-induced Association with c-Src, Osteoclast Spreading, and Bone Resorption

2003 • 117 citations

The resorption of biological and non-biological substrates by cultured avian and mammalian osteoclasts

1984 • 117 citations

Rho and Rac exert antagonistic functions on spreading of macrophage-derived multinucleated cells and are not required for actin fiber formation

2000 • 113 citations

Cytoskeletal changes in osteoclasts during the resorption cycle

1996 • 109 citations

Chemical and physical properties of the extracellular matrix are required for the actin ring formation in osteoclasts

1996 • 107 citations

Intracellular membrane trafficking in bone resorbing osteoclasts

2003 • 96 citations

Spatial organization of microfilaments and vitronectin receptor,αvβ3, in osteoclasts: A study using confocal laser scanning microscopy

1993 • 86 citations

Rac-GTPase, osteoclast cytoskeleton and bone resorption

1999 • 83 citations

Rho-dependent Rho Kinase Activation Increases CD44 Surface Expression and Bone Resorption in Osteoclasts

2003 • 77 citations

Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts

2002 • 72 citations

Differential Localization of Myosin II Isoforms in Resting and Activated Osteoclasts

2002 • 41 citations

Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption

2001 • 41 citations

Crystal‐induced neutrophil activation: VIII. Immediate production of prostaglandin E₂ mediated by constitutive cyclooxygenase 2 in human neutrophils stimulated by urate crystals

2003 • 32 citations

Use of glass slides coated with apatite-collagen complexes for measurement of osteoclastic resorption activity

2000 • 30 citations

Microtubule dynamics differentially regulates Rho and Rac activity and triggers Rho-independent stress fiber formation in macrophage polykaryons

2002 • 27 citations

Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential

1993 • 26 citations

Distinct Roles of p130^Casand c-Cbl in Adhesion-Induced or Macrophage Colony-Stimulating Factor-Mediated Signaling Pathways in Prefusion Osteoclasts

2003 • 24 citations

Structural characterization of glycoproteins

1988 • 18 citations

Evidence that failure of osteoid bone matrix resorption is caused by perturbation of osteoclast polarization.

1998 • 11 citations

Deleted Work

1955 • 0 citations