Eukaryotic Cell Locomotion Depends on the Propagation of Self-Organized Reaction–Diffusion Waves and Oscillations of Actin Filament Assembly

Role of cell shape in growth control

1978 • 2,434 citations

The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments

1998 • 1,388 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Actin microfilament dynamics in locomoting cells

1991 • 789 citations

The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling

1998 • 783 citations

A reaction–diffusion wave on the skin of the marine angelfish Pomacanthus

1995 • 779 citations

Spatiotemporal concentration patterns in a surface reaction: Propagating and standing waves, rotating spirals, and turbulence

1990 • 727 citations

Mechanism of Actin-Based Motility

2001 • 694 citations

Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling.

1985 • 637 citations

Chapter 2 Cultivation and Synchronous Morphogenesis of Dictyostelium under Controlled Experimental Conditions

1987 • 610 citations

The Human Arp2/3 Complex Is Composed of Evolutionarily Conserved Subunits and Is Localized to Cellular Regions of Dynamic Actin Filament Assembly

1997 • 504 citations

Observations on the social behaviour of cells in tissue culture

1953 • 492 citations

Cofilin promotes rapid actin filament turnover in vivo

1997 • 466 citations

Electrical Turbulence in Three-Dimensional Heart Muscle

1994 • 443 citations

Syrian Hamster Fibroblast Cell Line BHK21 and its Derivatives

1964 • 436 citations

Regulation of TNF-α-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells

1998 • 390 citations

The locomotion of fibroblasts in culture I. Movements of the leading edge

1970 • 389 citations

Cofilin Phosphorylation and Actin Cytoskeletal Dynamics Regulated by Rho- and Cdc42-Activated Lim-Kinase 2

1999 • 384 citations

Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis.

1991 • 333 citations

Control of actin polymerization in live and permeabilized fibroblasts.

1991 • 289 citations

Microfilament dynamics during cell movement and chemotaxis monitored using a GFP–actin fusion protein

1997 • 261 citations

Actin dynamics in living mammalian cells

1998 • 250 citations

Synergy between Actin Depolymerizing Factor/Cofilin and Profilin in Increasing Actin Filament Turnover

1998 • 218 citations

Relationship between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells after Epidermal Growth Factor Stimulation

1999 • 199 citations

Visualization and Molecular Analysis of Actin Assembly in Living Cells

1998 • 175 citations

The Actin Cytoskeleton Regulates LFA-1 Ligand Binding through Avidity Rather than Affinity Changes

1999 • 165 citations

Free calcium wave upon activation in Xenopus eggs

1987 • 164 citations

Turing-Type Patterns on Electrode Surfaces

2001 • 163 citations

Organizing centres for three-dimensional chemical waves

1984 • 160 citations

Microscopic spiral waves reveal positive feedback in subcellular calcium signaling

1993 • 157 citations

Is there a relationship between phosphatidylinositol trisphosphate and F-actin polymerization in human neutrophils?

1990 • 153 citations

Overexpression of cofilin stimulates bundling of actin filaments, membrane ruffling, and cell movement in Dictyostelium.

1996 • 147 citations

Actin-binding protein contributes to cell volume regulatory ion channel activation in melanoma cells.

1993 • 142 citations

The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension

2001 • 133 citations

Three-dimensional chemical waves in the Belousov–Zhabotinskii reaction

1983 • 126 citations

The Apical Na+/H+ Exchanger Isoform NHE3 Is Regulated by the Actin Cytoskeleton

1999 • 115 citations

Oscillations and morphogenesis

1993 • 109 citations

Scar/WAVE is localised at the tips of protruding lamellipodia in living cells

2001 • 101 citations

Actin Modulates the Gating of Neurospora crassa VDAC

2001 • 99 citations

The locomotion, shape and pseudopodial dynamics of unstimulated Dictyostelium cells are not random

1993 • 99 citations

Length distribution of F-actin in Dictyostelium discoideum.

1990 • 96 citations

Imaging Sustained Dissipative Patterns in the Metabolism of Individual Living Cells

2000 • 91 citations

Controlling cytoskeleton structure by phosphoinositide–protein interactions: phosphoinositide binding protein domains and effects of lipid packing

1999 • 88 citations

Modulation of a volume-regulated chloride current by F-actin

1995 • 87 citations

Model identification of a spatiotemporally varying catalytic reaction

1993 • 87 citations

Chemical vortex dynamics in three-dimensional excitable media

1988 • 81 citations

Cofilin: a missing link between T cell co-stimulation and rearrangement of the actin cytoskeleton

2000 • 78 citations

Spatial Patterns from Oscillating Microtubules

1989 • 76 citations

Simple and complex propagating reaction-diffusion fronts

1992 • 74 citations

Reaction–diffusion waves of actin filament polymerization/depolymerization in Dictyostelium pseudopodium extension and cell locomotion

2000 • 70 citations

The amoeboid movement of the mammalian leukocyte in tissue culture

1946 • 69 citations

Solubilized contact sites a from cell membranes of Dictyostelium discoideum

1975 • 62 citations

Osmotic regulation of intestinal epithelial Na⁺-K⁺-Cl⁻ cotransport: role of Cl⁻ and F-actin

1998 • 62 citations

Actin microfilaments control the MHC class II antigen presentation pathway in B cells

1998 • 60 citations

Interaction of the NG2 proteoglycan with the actin cytoskeleton

1996 • 60 citations

Traveling waves in yeast extract and in cultures of Dictyostelium discoideum

1998 • 60 citations

TheDictyostelium cytoskeleton

1995 • 59 citations

Regulation of G protein-coupled Receptor Kinase 5 (GRK5) by Actin

1998 • 55 citations

The fundamental motor of the human neutrophil is not random: evidence for local non-Markov movement in neutrophils

1994 • 55 citations

Calcium storage and release properties of F‐actin: evidence for the involvement of F‐actin in cellular calcium signaling

1996 • 52 citations

Role of F-actin in the activation of Na+-K+-Cl? cotransport by forskolin and vasopressin in mouse kidney cultured thick ascending limb cells

1994 • 47 citations

Binding of Protein Kinase C Isoforms to Actin in Aplysia

1998 • 46 citations

PDGF and neomycin induce similar changes in the actin cytoskeleton in human fibroblasts

1993 • 46 citations

Hydrodynamic flows traveling with chemical waves

1989 • 43 citations

Regulatory interaction of N-formyl peptide chemoattractant receptors with the membrane skeleton in human neutrophils.

1994 • 42 citations

Neutrophil leucocyte chemotaxis is not induced by a spatial gradient of chemoattractant

1986 • 39 citations

Cell movement and shape are non-random and determined by intracellular, oscillatory rotating waves in Dictyostelium amoebae

1994 • 37 citations

Global flow waves in chemically induced convection

1995 • 35 citations

Association of the γ12 subunit of G proteins with actin filaments

1997 • 34 citations

The regulation of chemotaxis and chemokinesis in Dictyostelium amoebae by temporal signals and spatial gradients of cyclic AMP

1994 • 34 citations

Circus movement in dissociated embryonic cells of a teleost,Oryzias latipes

1975 • 32 citations

Ca‐dependent regulation of Na⁺‐selective channels via actin cytoskeleton modification in leukemia cells

1997 • 32 citations

Modulation of ATP‐gated non‐selective cation channel (P2X₁ receptor) activation and desensitization by the actin cytoskeleton

1998 • 31 citations

Cellular automaton model of the actin cytoskeleton

1993 • 28 citations

Patterns of spontaneous motility in videomicrographs of human epidermal keratinocytes (HEK)

1995 • 24 citations

Insulin-Induced Circular Membrane Ruffling on Rat 1 Cells Expressing a High Number of Human Insulin Receptors: Circular Ruffles Caused by Rapid Actin Reorganization Exhibit High Density of Insulin Receptors and Phosphotyrosines

1993 • 20 citations

Pseudopodium extension and amoeboid locomotion in Dictyostelium discoideum: Possible autowave behaviour of F-actin

1997 • 19 citations

Periodic cell aggregation in suspensions of Dictyostelium discoideum

1989 • 18 citations

In situ measurements of external pH and optical density oscillations in Dictyostelium discoideum aggregates.

1986 • 17 citations

Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor

1997 • 16 citations

Spatio-Temporal Analysis of Multi-channel Alpha EEG Map Series

1987 • 13 citations

Is gamma-actin a regulator of amino acid transport?

1996 • 10 citations

Protein kinase C potentiation of currents from mouse ζ1/ε2 NMDA receptors expressed in Xenopus oocytes depends on f-actin/g-actin cycling

1999 • 8 citations

A 133Cs nuclear magnetic resonance study of endothelial Na(+)-K(+)-ATPase activity: can actin regulate its activity?

1997 • 7 citations

Nucleation and elongation of actin filaments in the presence of high speed supernate from neutrophil lysates: modulating effects of Ca2+ and phosphatidylinositol-4,5-bisphosphate

1998 • 6 citations