In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

2002 • 10,849 citations

Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides

2002 • 8,015 citations

1,3-Dipolar Cycloaddition Chemistry

1984 • 3,261 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

1993 • 872 citations

The Cholinesterases: From Genes to Proteins

1994 • 650 citations

Drug discovery by dynamic combinatorial libraries

2002 • 476 citations

Site-directed ligand discovery

2000 • 446 citations

Electronic and Steric Effects on Catalysts for CO2/Epoxide Polymerization: Subtle Modifications Resulting in Superior Activities

2002 • 442 citations

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

1993 • 431 citations

Growing range of correlated motion in a polymer melt on cooling towards the glass transition

1999 • 394 citations

Drug research: myths, hype and reality

2003 • 347 citations

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

2004 • 318 citations

In Situ Generation and Screening of a Dynamic Combinatorial Carbohydrate Library against Concanavalin A

2000 • 216 citations

Handbook of Combinatorial Chemistry

2002 • 216 citations

In situ assembly of enzyme inhibitors using extended tethering

2003 • 193 citations

Impact-Induced Cleaving and Melting of Alkali-Halide Nanocrystals

1991 • 177 citations

Hydrogen Sulfide Oxidation Is Coupled to Oxidative Phosphorylation in Mitochondria of Solemya reidi

1986 • 169 citations

Nonhazardous Direct Oxidation of Hydrogen to Hydrogen Peroxide Using a Novel Membrane Catalyst

2001 • 157 citations

Dynamic Deconvolution of a Pre-Equilibrated Dynamic Combinatorial Library of Acetylcholinesterase Inhibitors

2001 • 141 citations

Dynamic Combinatorial Carbohydrate Libraries: Probing the Binding Site of the Concanavalin A Lectin

2004 • 124 citations

Selective reduction of aryl halides and .alpha.,.beta.-unsaturated esters with sodium borohydride-cuprous chloride in methanol and its application to deuterium labeling

1989 • 118 citations

Highly Enantioselective Desymmetrization of Anhydrides by Carbon Nucleophiles: Reactions of Grignard Reagents in the Presence of (−)-Sparteine

2002 • 117 citations

Self-Assembling Cytotoxins

1986 • 112 citations

Combinatorial Chemistry

1998 • 96 citations

Interaction Kinetics of Reversible Inhibitors and Substrates with Acetylcholinesterase and Its Fasciculin 2 Complex

2001 • 77 citations

Synergism through direct covalent bonding between agents: A strategy for rational design of chemotherapeutic combinations

1990 • 64 citations

Soluble monomeric acetylcholinesterase from mouse: Expression, purification, and crystallization in complex with fasciculin

1996 • 62 citations

Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-Guided ligand assembly

2002 • 45 citations

Unexpected Formation of an Epoxide-Derived Multisubstrate Adduct Inhibitor on the Active Site of GAR Transformylase^,

2001 • 41 citations

Multisubstrate adduct inhibitors of glycinamide ribonucleotide transformylase: Synthetic and enzyme-assembled.

1991 • 35 citations