Drug discovery by dynamic combinatorial libraries

Einfluss der Configuration auf die Wirkung der Enzyme

1894 • 1,695 citations

Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries

1999 • 864 citations

Self‐Assembly of a Circular Double Helicate

1996 • 627 citations

Self-Assembly of Tetra- and Hexanuclear Circular Helicates

1997 • 552 citations

Self-recognition in helicate self-assembly: spontaneous formation of helical metal complexes from mixtures of ligands and metal ions.

1993 • 532 citations

Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly

1997 • 438 citations

Dynamic Combinatorial Chemistry

2001 • 391 citations

Dynamic Combinatorial Libraries of Macrocyclic Disulfides in Water

2000 • 257 citations

In Situ Generation and Screening of a Dynamic Combinatorial Carbohydrate Library against Concanavalin A

2000 • 216 citations

Guest-Selected Formation of Pd(II)-Linked Cages from a Prototypical Dynamic Library

1999 • 183 citations

Organic “Magic Rings”: The Hydrogen Bond-Directed Assembly of Catenanes under Thermodynamic Control

1999 • 180 citations

Supramolecular Science Where it is and where it is going

1998 • 177 citations

Dynamic Assembly of Coordination Boxes from (en)Pd(II) Unit and a Rectangular Panel-Like Ligand: NMR, CSI-MS, and X-ray Studies

2001 • 166 citations

Automated Recognition, Sorting, and Covalent Self-Assembly by Predisposed Building Blocks in a Mixture

1997 • 158 citations

Double-level “orthogonal” dynamic combinatorial libraries on transition metal template

2001 • 148 citations

Molecular evolution: dynamic combinatorial libraries, autocatalytic networks and the quest for molecular function

2000 • 145 citations

Chemical Evolution: A Model System That Selects and Amplifies a Receptor for the Tripeptide (<scp>d</scp>)Pro(<scp>l</scp>)Val(<scp>d</scp>)Val

1998 • 142 citations

Dynamic Deconvolution of a Pre-Equilibrated Dynamic Combinatorial Library of Acetylcholinesterase Inhibitors

2001 • 141 citations

Supramolecular Polymers

2000 • 141 citations

Template-directed synthesis: use of a reversible reaction

1992 • 140 citations

Adaptive Self-Assembly: Environment-Induced Formation and Reversible Switching of Polynuclear Metallocyclophanes

2000 • 137 citations

Molecular Paneling via Coordination: Guest-Controlled Assembly of Open Cone and Tetrahedron Structures from Eight Metals and Four Ligands

2000 • 134 citations

Chloroform-Soluble Schiff-Base Zn(II) or Cd(II) Complexes from a Dynamic Combinatorial Library

2001 • 133 citations

‘Living’ macrolactonisation: thermodynamically-controlled cyclisation and interconversion of oligocholates

1996 • 130 citations

Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria

2000 • 125 citations

Template-Induced and Molecular Recognition Directed Hierarchical Generation of Supramolecular Assemblies from Molecular Strands

2000 • 121 citations

Guest-induced reorganization of a self-assembled Pd(II) complex

1998 • 117 citations

Dynamic Hemicarcerands and Hemicarceplexes

2000 • 109 citations

Reversible synthesis of π-associated [2]catenanes by ring-closing metathesis: towards dynamic combinatorial libraries of catenanes

1998 • 109 citations

Dynamic combinatorial libraries of pseudo-peptide hydrazone macrocycles

1999 • 108 citations

Use of Molecular Recognition To Drive Chemical Evolution. 1. Controlling the Composition of an Equilibrating Mixture of Simple Arginine Receptors

1997 • 107 citations

Nonspecific protease-catalyzed hydrolysis/synthesis of a mixture of peptides: Product diversity and ligand amplification by a molecular trap

1996 • 105 citations

Generation of an equilibrating collection of circular inorganic copper(i) architectures and solid-state stabilisation of the dicopper helicate component

1997 • 105 citations

Identification and Isolation of a Receptor forN-Methyl Alkylammonium Salts: Molecular Amplification in a Pseudo-peptide Dynamic Combinatorial Library

2001 • 101 citations

Strategies for the Dynamic Integration of Combinatorial Synthesis and Screening

1998 • 97 citations

Combinatorial Chemistry

1998 • 96 citations

Identification and Isolation of a Receptor for N-Methyl Alkylammonium Salts: Molecular Amplification in a Pseudo-peptide Dynamic Combinatorial Library This work was supported by the Biotechnology and Biological Sciences Research Council (UK), Engineering and Physical Sciences Research Council (UK), Ethyl Corporation (UK), and Fundacion Antorchas and Consejo Nacional de Investigaciones Cientficas y Tecnicas (Argentina).

2001 • 95 citations

Generation of novel DNA-binding compounds by selection and amplification from self-assembled combinatorial libraries

1997 • 93 citations

Imine exchange inO-aryl andO-alkyl oximes as a base reaction for aqueous ‘dynamic’ combinatorial libraries. A kinetic and thermodynamic study

1999 • 91 citations

Template-Directed Self-Recognition of Alkyl-Bridged Bis(catechol) Ligands in the Formation of Helicate-Type Complexes

1999 • 91 citations

Episelection: Novel Ki .apprx. Nanomolar Inhibitors of Serine Proteases Selected by Binding or Chemistry on an Enzyme Surface

1995 • 89 citations

Guest-Templated Selection and Amplification of a Receptor by Noncovalent Combinatorial Synthesis

2000 • 88 citations

Cent Mille Milliards de poèmes

1961 • 84 citations

Diversity and Selection in Self-Assembled Tetrameric Capsules

2000 • 84 citations

Self- and hetero-recognition in the guest-controlled assembly of Pd(ii)-linked cages from two different ligands

2000 • 83 citations

Thermodynamically-controlled cyclisation and interconversion of oligocholates: metal ion templated ‘living’ macrolactonisation

1997 • 79 citations

Bioaffinity NMR Spectroscopy: Identification of an E-Selectin Antagonist in a Substance Mixture by Transfer NOE

1999 • 79 citations

An Expansible Metalla-cryptand as a Component of a Supramolecular Combinatorial Library Formed from Di(8-hydroxyquinoline) Ligands and Gallium(III) or Zinc(II) Ions

1999 • 74 citations

Structure‐Directed Synthesis under Thermodynamic Control: Macrocyclic Trimers from Cinchona Alkaloids

1996 • 67 citations

A self-adjusting carbohydrate ligand for GalNAc specific lectins

1997 • 67 citations

Use of Molecular Recognition To Drive Chemical Evolution: Mechanisms of an Automated Genetic Algorithm Implementation

1998 • 64 citations

Impact of mass spectrometry on combinatorial chemistry

1999 • 64 citations

Selection of DNA-binding compounds via multistage molecular evolution

1999 • 63 citations

Induced Fit Selection of a Barbiturate Receptor from a Dynamic Structural and Conformational/Configurational Library

1999 • 60 citations

Dynamic diversity and small-molecule evolution: a new paradigm for ligand identification

1999 • 60 citations

Molecular amplification in a dynamic combinatorial library using non-covalent interactions

2000 • 60 citations

A Virtual Library Approach To Investigate Protein Folding and Internal Packing

2000 • 58 citations

Dynamic Combinatorial Chemistry: Substrate H-Bonding Directed Assembly of Receptors Based on Bipyridine-Metal Complexes

1999 • 57 citations

Dioxadiazadecalin/Salen Tautomeric Macrocycles and Complexes: Prototypal Dynamic Combinatorial Virtual Libraries

2000 • 52 citations

Libraries of non-covalent hydrogen-bonded assemblies; combinatorial synthesis of supramolecular systems

1998 • 50 citations

Covalent capture of dynamic hydrogen-bonded assemblies

2000 • 50 citations

Metal-ion-controlled transamination in the synthesis of macrocyclic Schiff-base ligands. Part 1. Reactions of 2,6-diacetylpyridine and dicarbonyl compounds with 3,6-dioxaoctane-1,8-diamine

1981 • 49 citations

“Masterpiece” Copolymer Sequences by Targeted Equilibrium-Shifting

2000 • 47 citations

Libraries for Receptor-Assisted Combinatorial Synthesis (RACS). The Olefin Metathesis Reaction

1998 • 35 citations

Librariesvia Metathesis of Internal Olefins

1998 • 34 citations

Building thermodynamic combinatorial libraries of quinine macrocycles

1997 • 32 citations

Binuclear complexes of macrocyclic schiff base ligands as hosts for small substrate molecules

1982 • 31 citations

Engineering diversity into dynamic combinatorial libraries by use of a small flexible building block

1998 • 31 citations

Diazadioxadecalin and salen podands and macrocycles within dynamic combinatorial virtual libraries: structure, prototropy, complexation and enantioselective catalysis

2001 • 30 citations

A Combinatorial Approach to Synthetic Receptors

1999 • 28 citations

Combinatorial Chemistry

2000 • 28 citations

Essays in contemporary chemistry : from molecular structure towards biology

2001 • 21 citations

Synthesis of soluble combinatorial libraries of crown ether-ester analogues via the cyclodepolymerisation of linear polyesters

1999 • 21 citations

Chiral 1,2-ethanediyl-spaced quaterpyridines give a library of cyclic and double helicates with copper(I)

1999 • 20 citations

ChemInform Abstract: THE OLEFIN METATHESIS REACTION

1978 • 14 citations

The Institute of Chemistry of Great Britain and Ireland. Journal and Proceedings. 1929. Part VI

1929 • 13 citations

Supramolecular Science Where it is and where it is going

1998 • 6 citations