Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

1997 • 14,729 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

1990 • 3,683 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

1999 • 1,318 citations

Acetylcholinesterase — new roles for an old actor

2001 • 1,289 citations

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

1996 • 1,058 citations

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

1993 • 872 citations

Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks

2002 • 714 citations

THE ACTION OF CERTAIN ESTERS AND ETHERS OF CHOLINE, AND THEIR RELATION TO MUSCARINE

1914 • 604 citations

Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins

1993 • 570 citations

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

2002 • 459 citations

Structures, Alternative Splicing, and Neurexin Binding of Multiple Neuroligins

1996 • 438 citations

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

1993 • 431 citations

Cation–π interactions in ligand recognition and catalysis

2002 • 422 citations

Two conformational states of Candida rugosa lipase

1994 • 371 citations

Structural Mechanisms of QacR Induction and Multidrug Recognition

2001 • 367 citations

Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

1975 • 357 citations

Acetylcholinesterase inhibition by fasciculin: Crystal structure of the complex

1995 • 347 citations

Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs.

1966 • 308 citations

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

2000 • 302 citations

Cucurbituril

1995 • 280 citations

Open "Back Door" in a Molecular Dynamics Simulation of Acetylcholinesterase

1994 • 259 citations

Crystal structure of an acetylcholinesterase–fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

1995 • 236 citations

Molecular cloning of mouse acetylcholinesterase: Tissue distribution of alternatively spliced mRNA species

1990 • 168 citations

Conformational Flexibility of the Acetylcholinesterase Tetramer Suggested by X-ray Crystallography

1999 • 164 citations

Thioflavin T Is a Fluorescent Probe of the Acetylcholinesterase Peripheral Site That Reveals Conformational Interactions between the Peripheral and Acylation Sites

2001 • 134 citations

Crystal Structure of Mouse Acetylcholinesterase

1999 • 128 citations

Molecular Dynamics of Acetylcholinesterase

2002 • 128 citations

Inhibition of the SHV-1 β-Lactamase by Sulfones: Crystallographic Observation of Two Reaction Intermediates with Tazobactam^,

2001 • 79 citations

Soluble monomeric acetylcholinesterase from mouse: Expression, purification, and crystallization in complex with fasciculin

1996 • 62 citations

Three‐dimensional structures of glycolate oxidase with bound active‐site inhibitors

1997 • 58 citations

The “back door” hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis.

1994 • 56 citations

Nanosecond Dynamics of the Mouse Acetylcholinesterase Cys69–Cys96 Omega Loop

2003 • 38 citations

Inhibitors of Different Structure Induce Distinguishing Conformations in the Omega Loop, Cys69–Cys96, of Mouse Acetylcholinesterase

2002 • 28 citations

A study of interaction of thioflavine T with DNA: evidence for intercalation.

1987 • 23 citations