Phenylalanine positively modulates the cAMP‐dependent phosphorylation and negatively modulates the vasopressin‐induced and okadaic‐acid‐induced phosphorylation of phenylalanine 4‐monooxygenase in intact rat hepatocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

Simplified method for silver staining of proteins in polyacrylamide gels and the mechanism of silver staining

1985 • 1,359 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem

1989 • 411 citations

The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells

1991 • 330 citations

Purification and characterization of the catalytic subunit of adenosine 3':5'-cyclic monophosphate-dependent protein kinase from bovine liver

1976 • 295 citations

Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II.

1986 • 293 citations

A simple purification of phenylalanine hydroxylase by substrate-induced hydrophobic chromatography.

1979 • 191 citations

Identification of protein phosphatase 1 in synaptic junctions: dephosphorylation of endogenous calmodulin-dependent kinase II and synapse-enriched phosphoproteins

1985 • 162 citations

In vitro activation of rat liver phenylalanine hydroxylase by phosphorylation.

1976 • 149 citations

The enzymic conversion of 4-fluorophenylalanine to tyrosine

1961 • 124 citations

Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains

1985 • 121 citations

Hexokinase of Human Erythrocytes

1974 • 115 citations

The multifunctional Ca2+/calmodulin-dependent protein kinase.

1988 • 99 citations

Ca2+/calmodulin kinase is activated by the phosphatidylinositol signaling pathway and becomes Ca2(+)-independent in PC12 cells.

1990 • 98 citations

Isolation and sequence of a cDNA clone which contains the complete coding region of rat phenylalanine hydroxylase. Structural homology with tyrosine hydroxylase, glucocorticoid regulation, and use of alternate polyadenylation sites.

1986 • 89 citations

Molecular basis and population genetics of phenylketonuria

1989 • 79 citations

The effect of ligands of phenylalanine 4-monooxygenase on the cAMP-dependent phosphorylation of the enzyme.

1984 • 75 citations

Regulation of phenylalanine hydroxylase activity by phenylalanine in vivo, in vitro, and in perfused rat liver.

1982 • 71 citations

Okadaic acid stimulates the activity of microtubule associated protein kinasein PC-12 pheochromocytoma cells

1990 • 64 citations

[11] Use of synergistic pairs of site-selective cAMP analogs in intact cells

1988 • 60 citations

Recurrent mutation, gene conversion, or recombination at the human phenylalanine hydroxylase locus: evidence in French-Canadians and a catalog of mutations.

1990 • 60 citations

Amino acid sequence at the phosphorylated site of rat liver phenylalanine hydroxylase and phosphorylation of a corresponding synthetic peptide

1980 • 60 citations

The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function

1984 • 55 citations

The expression of cAMP-dependent protein kinase subunits is differentially regulated during liver regeneration

1989 • 53 citations

The protein phosphatases involved in cellular regulation. Glycolysis, gluconeogenesis and aromatic amino acid breakdown in rat liver

1984 • 52 citations

Some aspects of the phosphorylation of phenylalanine 4-monooxygenase by a calcium-dependent and calmodulin-dependent protein kinase

1984 • 52 citations

The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase

1991 • 52 citations

Evidence for the activation of the multifunctional Ca2+/calmodulin-dependent protein kinase in response to hormones that increase intracellular Ca2+.

1987 • 47 citations

Phosphorylation of L-type pyruvate kinase by a Ca2+/calmodulin-dependent protein kinase.

1985 • 46 citations

The separate estimation of cAMP intracellularly bound to the regulatory subunits of protein kinase I and II in glucagon-stimulated rat hepatocytes.

1985 • 44 citations

A simple assay method for determination of the specific radioactivity of the γ-phosphate group of 32P-labelled ATP.

1983 • 40 citations

Phenylalanine hydroxylase in liver cells. Correlation of glucagon-stimulated enzyme phosphorylation with expressed activity

1984 • 40 citations

Ligand effects on the phosphorylation state of hepatic phenylalanine hydroxylase.

1984 • 36 citations

Phenylalanine 4-monooxygenase from bovine and rat liver: Some physical and chemical properties

1982 • 36 citations

Functional analysis of the effect of monoclonal antibodies on monkey liver phenylalanine hydroxylase

1986 • 29 citations

The mechanism of the irreversible inhibition ofrat liver phenylalanine hydroxylase due to treatment with p-chlorophenylalanine. The lack of effect on turnover of phenylalanine hydroxylase.

1979 • 24 citations

Modulation by pterins of the phosphorylation and phenylalanine activation of phenylalanine 4-mono-oxygenase

1987 • 23 citations

A 3-base pair in-frame deletion of the phenylalanine hydroxylase gene results in a kinetic variant of phenylketonuria

1991 • 22 citations

A monoclonal antibody to the phosphorylated form of phenylalanine hydroxylase. Definition of the phosphopeptide epitope

1987 • 17 citations

Heterogeneity of phenylketonuria at the clinical, protein and DNA levels

1989 • 14 citations

2 Pyruvate Kinase

1987 • 12 citations

[22] Substrate-directed regulation of cAMP-dependent phosphorylation

1983 • 11 citations

Experimental determination of the phosphorylation state of phenylalanine hydroxylase

1990 • 10 citations

Control of phenylalanine and tyrosine metabolism by phosphorylation mechanisms

1986 • 10 citations