Effect of okadaic acid on hormone- and mastoparan-stimulated phosphoinositide turnover in isolated rat hepatocytes

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

The role of protein phosphorylation in neural and hormonal control of cellular activity

1982 • 1,116 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

1988 • 674 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

1987 • 524 citations

A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii.

1979 • 278 citations

Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes

1988 • 249 citations

Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.

1985 • 218 citations

Stimulation of inositol trisphosphate formation in hepatocytes by vasopressin, adrenaline and angiotensin II and its relationship to changes in cytosolic free Ca2+

1985 • 212 citations

Feedback regulation of phospholipase C-beta by protein kinase C.

1990 • 212 citations

Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.

1987 • 203 citations

Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.

1985 • 199 citations

Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.

1986 • 198 citations

Phorbol esters inhibit alpha1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes

1984 • 114 citations

Phorbol esters inhibit alpha 1-adrenergic effects and decrease the affinity of liver cell alpha 1-adrenergic receptors for (-)-epinephrine.

1986 • 105 citations

Depolarization-stimulated 42K+ efflux in rat aorta is calcium- and cellular volume-dependent.

1987 • 82 citations

Multigranular exocytosis induced by phospholipase A2-activators, melittin and mastoparan, in rat anterior pituitary cells

1986 • 60 citations

Angiotensin II stimulates phosphoinositide turnover and phosphorylase through AII-1 receptors in isolated rat hepatocytes

1990 • 52 citations

Control of glycogen phosphorylase interconversion by phorbol esters, diacylglycerols, Ca2+ and hormones in isolated rat hepatocytes

1985 • 43 citations

Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2

1991 • 41 citations

Gi-2 at the centre of an active phosphorylation/dephosphorylation cycle in hepatocytes: The fine-tuning of stimulatory and inhibitory inputs into adenylate cyclase in normal and diabetic states

1991 • 30 citations

Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca²⁺ concentration but not by an increase of cAMP in rat hepatocytes

1990 • 23 citations